Research progress on brain-derived neurotrophic factor and non-suicidal self-injury addictive behavior associated with depressive disorders in adolescents

In recent years,non-suicidal self-injury(NSSI)behavior has emerged in a large number of adoles-cent depression.NSSI associated with adolescent depres-sion may be an addictive behavior,which has many sim-ilar neurobiological mechanisms to substance addiction.Brain-derived neurotrophic factor(BDNF)and precursor of BDNF(proBDNF)play an important role in addiction behavior,and they may be related to endogenous opioid receptors.The location and distribution of opioidμre-ceptors in the brain are related to reward,motivation and emotion regulated by behavioral addiction.The purpose of this paper is to review the general situation,mechanism and relationship between the characteristics of NSSI be-havior addiction and brain-derived nutritional factors in adolescents with depression.

Research progress on the relationship between proBDNF and alcohol dependence and its related cognitive impairment

Brain-derived neurotrophic factor(BDNF)plays an important role in the growth,develop-ment,differentiation,injury,repair,survival and apoptosis of nerve cells.Precursor of BDNF(proBDNF)is an im-portant regulator of neurodegeneration,long-term hippo-campal inhibition and synaptic plasticity.Alcohol depen-dence syndrome(ADS)is a group of chronic recurrent diseases with unknown etiology.Current studies believe that proBDNF plays an important role in the occurrence,development and outcome of ADS.Alcohol dependence patients,like other neurodegenerative diseases,will also have different degrees of cognitive impairment.This arti-cle reviews the research progress on the relationship be-tween BDNF,proBDNF,alcohol dependence and cogni-tive impairment.

Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia

Schizophrenia(SCZ)is a serious mental illness whose etiology and pathogenesis are not yet clear.The level of miRNA may be a crucial factor in the occurrence and development of SCZ.This study found that miR-495 may regulate the susceptibility gene of SCZ and that proteolipid protein 1(PLP1)as a risk gene for schizophrenia may be involved in its pathogenesis.In this article we review the research progress related to hsa-miR-495-3p(miR-495),PLP1,and schizophrenia.

Research progress on benzodiazepines to treat alcohol withdrawal syndrome

Alcohol withdrawal syndrome(AWS)refers to a series of symptoms and signs that chronic al-coholics experience when they suddenly stop drinking or reduce their drinking,usually 12 to 24 h later.These in-clude tremors,fatigue,sweating,hyperreflexia,and gas-trointestinal symptoms.This article will analyze the drug treatment of this disease and make a brief review.

Changes and clinical significance of BDNF and MMP9 be-fore and after treatment of depressive episode

Objective:to explore brain-derived neu-rotrophic factor(BDNF)and matrix metalloproteinase-9(MMP9)messenger in peripheral blood lymphocytes of patients with depressive episodes before and after anti-depressant treatment changes in RNA(mRNA)expres-sion levels.Methods:fifteen patients hospitalized with depression in the Afiliated Mental Hospital of Kunming Medical University from December 2021 to June 2022 were collected as research objects.After 4 weeks of anti-depressant treatment,BDNF mRNA and MMP9 mRNA in patients with depression were detected before and af-ter treatment,and statistically analyzed.Results:after 4 weeks of antidepressant treatment,there was no signif-icant difference in BDNF mRNA expression level after treatment compared with before treatment(P>0.05).The mRNA level of MMP9 was higher than that before treatment,and the difference was statistically significant(P<0.05).Conclusion:antidepressant therapy increases the expression of MMP9 mRNA,increasing the conver-sion of BDNF precursor(proBDNF)to mature for BDNF(mBDNF)to relieve depressive symptoms,and the total content of BDNF did not change significantly.

Phenobarbital in the treatment of alcohol withdrawal syndrome

Alcohol withdrawal syndrome(AWS)is a serious disorder affecting alcohol-dependent patients who abruptly stop or reduce their drinking.Mild or moderate AWS usually appears within 6 to 24 h after the last drink,and symptoms may include increased blood pressure and rapid pulse,tremors,high fever,irritability,anxiety,headache,nausea,and vomiting.These symptoms may progress to a more severe AWS characterized by delirium tremens,seizures,coma,cardiac arrest,and death.This article will analyze the phenobarbital(PB)treatment of AWS and make a brief review'.

Research progress on BDNF in Sjogren's syndrome with depressive disorder

Brain-derived neurotrophic factor(BDNF)is a widely studied neurotrophic factor,which plays an important role in the growth,development,dif-ferentiation,injury,repair,survival and apoptosis of nerve cells.More and more studies have found that there is a high prevalence of depressive disorders in patients with autoimmune diseases.Sjogren's syndrome is a chronic autoimmune exocrine disease characterized by lympho-cytic infiltration and exocrine gland destruction.Depres-sive disorders are common in patients with Sjogren's syndrome.The quality of life of patients with Sjogren's syndrome with depression was generally lower than that of patients with Sjogren's syndrome without depres-sion.In this article,we reviewed the research progress of BDNF and depression in Sjogren's syndrome at home and abroad.

Research progress on whether BDNF can be used as a predictive biomarkerfor suicidal behavior

In recent years,the serious social phe-nomenon of suicide has been of great concern to society and academia.However,the study and early risk assess-ment of suicide have been limited by multiple aspects.Therefore,researchers have started to search for a reliable marker for early diagnosis of suicide risk,and one of the widely studied neurotransmitters associated with suicide is the brain-derived neurotrophic factor(BDNF).This re-view aims to summarize the current scientific knowledge on the relevance of BDNF and psychiatric disorders to suicide and to infer whether neurotrophic factors could be a reliable marker for early diagnosis of suicide risk.Based on the results of these studies,a link between BDNF and suicide may exist and act independently of mental illness.However,there is still controversy and further studies may provide researchers with useful information.

Advances in the prediction of biological markers of alcohol dependence relapse

Alcohol dependence is a chronic and re-lapsing disease that causes mental and organ damage due to long-term heavy drinking,which has serious adverse effccts on individuals and socicty.Previous studics have shown that even after inpatient treatment,the relapse rate of alcohol-dependent patients can be as high as 60%-70%within 3 months after discharge.Currently,the mecha-nisms associated with relapse to drinking in alcohol-dependent patients are still unclear.And most of the studies reported in the past have been about the relationship between psychosocial factors and relapse to drinking,while few studies have examined the relationship between bi-ological indicators and relapse to drinking.Therefore,in this paper,we summarize the recent literature to explore the biological markers related to alcohol dependence relapse and discuss the progress of research on relapse pre-diction,in order to provide reference and help to reduce the relapse rate and improve the quality of life of patients.

具有学习和推理能力的空间无人系统智能架构

以卫星、飞船、深空探测器为代表的航天器是一类典型的无人系统,经历了从自动化到自主化的不断发展.为提升航天器对未知空间环境和复杂空间任务的适应能力和智能自主水平,以空间无人系统为研究对象设计了具有学习和推理能力的无人系统智能架构,给出架构的组成及功能;接着分析该架构中学习和推理能力的运作机制,并针对架构所需的动作库和知识库的构建、更新与扩展方法等关键技术提出解决方案;最后通过地外星表巡视采样任务示例,具体说明在该智能架构下的新知识生成、基于知识的推理和自主执行任务的过程,以及过程中知识库、环境、任务和动作库之间的交互关系.