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蒙药地格达-4颗粒成型工艺研究
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作者 田香 拉喜那木吉拉 +4 位作者 哈日呼 美丽 张尧 饶小勇 罗晓健 《中国药业》 CAS 2022年第15期33-38,共6页
目的优选蒙药地格达-4颗粒的成型工艺。方法以颗粒得率、脆碎度、溶化时间为考察指标,采用单因素试验结合中心复合试验设计优选颗粒处方参数及干法制粒工艺参数,并对制得的颗粒进行质量检查。结果最佳制备工艺参数为蒙药地格达-4喷雾干... 目的优选蒙药地格达-4颗粒的成型工艺。方法以颗粒得率、脆碎度、溶化时间为考察指标,采用单因素试验结合中心复合试验设计优选颗粒处方参数及干法制粒工艺参数,并对制得的颗粒进行质量检查。结果最佳制备工艺参数为蒙药地格达-4喷雾干燥粉-乳糖-微粉硅胶(9∶1∶5‰,m∶m∶m),干法制粒机液压40 bar,滚轮间隙1 mm,滚轮转速3.0 r/min,破碎频率30 Hz,所制得的颗粒得率、溶化时间等项目检查都符合2020年版《中国药典(四部)》要求。结论优选出的蒙药地格达-4颗粒成型工艺可行,可为工业化生产提供参考。 展开更多
关键词 蒙药 地格达-4颗粒 中心复合设计 制备工艺
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Ultrastructural Observation of the Skin Chloride Celis of Japanese Flounder Paralichthys olivaceus and Turbot Scophthamus maximus Larvae
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作者 朱杰 Zhang +2 位作者 Xiumei Gao tianxiang 《High Technology Letters》 EI CAS 2003年第1期31-34,共4页
The ultrastructures of skin chloride celis in cultured Japanese flounder and turbot larvae in metamorphosis, which grow in the same feeding conditions, are examined with a transmission electron microscope. These devel... The ultrastructures of skin chloride celis in cultured Japanese flounder and turbot larvae in metamorphosis, which grow in the same feeding conditions, are examined with a transmission electron microscope. These developed skin chloride celis were shaped like flattened ellipsoids and similar in morphology and ultrastructure to typical chloride celis of euryhaline fish gill. They lo-cate in the epidermis and contract with the extra and interior environment through the apical pit and narrow channels. The cytoplasm of cell is full of numerous mitochondria and a ramifying net-work of tubules. The degeneration of skin chloride celis is observed with development of Japanese flounder larvae. Skin chloride celis of turbot are less developmental than those of Japanese flounder in the same developmental stage. 展开更多
关键词 ULTRASTRUCTURE skin chloride cell Paralichthys olivaceus Scophthamus maximus LARVAE
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