Dear Editor,Antimicrobial peptides(AMPs)are an ancient class of short polypeptides present in a large number of species in nature with a variety of functions.1 PFR(PFWRIRIRR-NH 2)is one kind of AMP identified among th...Dear Editor,Antimicrobial peptides(AMPs)are an ancient class of short polypeptides present in a large number of species in nature with a variety of functions.1 PFR(PFWRIRIRR-NH 2)is one kind of AMP identified among the derivatives of lactoferrin.2 Our previous results showed that PFR inhibited the proliferation of human acute myeloid leukemia(AML)HL60 cells potentially without toxicity against normal cells.In addition,PFR induced necrosis by membrane disruption detected using scanning electron micro-scopy.3 However,the underlying mechanisms of these effects are not clearly understood.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China(No.81770176)the New Century 151 Talent Project of Zhejiang Province,the 521 Talent Foundation and the Fundamental Research Funds of Zhejiang Sci-Tech University(No.2019Y001)the Science Technology Department of Zhejiang Province(No.LGC19H080001).
文摘Dear Editor,Antimicrobial peptides(AMPs)are an ancient class of short polypeptides present in a large number of species in nature with a variety of functions.1 PFR(PFWRIRIRR-NH 2)is one kind of AMP identified among the derivatives of lactoferrin.2 Our previous results showed that PFR inhibited the proliferation of human acute myeloid leukemia(AML)HL60 cells potentially without toxicity against normal cells.In addition,PFR induced necrosis by membrane disruption detected using scanning electron micro-scopy.3 However,the underlying mechanisms of these effects are not clearly understood.
