Cholangiocarcinoma(CCA)is the second most common hepatobiliary cancer,and its incidence has increased significantly in recent years.CCA has poor prognosis owing to the limited diagnosis and treatment options.The tumor...Cholangiocarcinoma(CCA)is the second most common hepatobiliary cancer,and its incidence has increased significantly in recent years.CCA has poor prognosis owing to the limited diagnosis and treatment options.The tumor immune microenvironment(TIME),which comprises immune cells,cytokines,and chemokines,plays a significant role in cancer progression,the evasion of immune surveillance,and therapeutic responses.Immunotherapeutic strategies targeting the TIME offer the potential for the recognition and eradication of CCA.This review discusses the cellular and molecular components of the TIME in CCA and immunotherapeutic strategies targeting it.展开更多
基金Supported by grants from the Research Fund of the Health Commission of Hubei Province(No.WJ2021M255)Cancer Research and Translational Platform Project of Zhongnan Hospital of Wuhan University(No.ZLYNXM202004)+2 种基金Key Research and Development Program of Hubei Province(No.2021BCA114)the Research Fund from the Medical Sci-Tech Innovation Platform of Zhongnan Hospital of Wuhan University(No.PTXM2021022)the Outstanding Doctoral(Postdoctoral)Program of Zhongnan Hospital of Wuhan University(No.ZNYB2021021)。
文摘Cholangiocarcinoma(CCA)is the second most common hepatobiliary cancer,and its incidence has increased significantly in recent years.CCA has poor prognosis owing to the limited diagnosis and treatment options.The tumor immune microenvironment(TIME),which comprises immune cells,cytokines,and chemokines,plays a significant role in cancer progression,the evasion of immune surveillance,and therapeutic responses.Immunotherapeutic strategies targeting the TIME offer the potential for the recognition and eradication of CCA.This review discusses the cellular and molecular components of the TIME in CCA and immunotherapeutic strategies targeting it.
