In the era of rapid development of informatization,the informatization construction of national higher vocational colleges has been in the period of application deepening.China's education system is deepening to t...In the era of rapid development of informatization,the informatization construction of national higher vocational colleges has been in the period of application deepening.China's education system is deepening to the development of mass education,and higher vocational colleges'adult continuing education plays a great role for the realization of education popularization.With the continuous expansion of continuing education enrollment scale,the diversified development of education mode,the higher complexity of continuing education management and the increase of management workload,the traditional management method has gradually become unapplicable.Higher vocational colleges can greatly improve the management level by promoting the informatization of education management according to their own professional or regional advantages.展开更多
We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose c...We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose consumption in L6 myotubes,taking 1 as the lead.In high-fat diet(HFD)and STZ induced diabetic mice,9a significantly lowers blood glucose,improves glucose tolerance,and especially alleviates diabetic nephropathy and islet damage.Mechanism study indicates that 9a simultaneously targets mitochondrial complex I to increase AMP/ATP ratio,as well as liver kinase B1(LKB1)and calcium/calmodulindependent protein kinase(Ca MKK),which synergistically activates AMPKαand then stimulates glucose transporter 4(GLUT4)membrane translocation and 2-deoxyglucose(2-DG)uptake to exert anti-diabetic efficacy.Therefore,compound 9a with a novel structure is a promising anti-diabetic candidate with the advantage of multiple-target mechanism,worthy of further investigation.展开更多
文摘In the era of rapid development of informatization,the informatization construction of national higher vocational colleges has been in the period of application deepening.China's education system is deepening to the development of mass education,and higher vocational colleges'adult continuing education plays a great role for the realization of education popularization.With the continuous expansion of continuing education enrollment scale,the diversified development of education mode,the higher complexity of continuing education management and the increase of management workload,the traditional management method has gradually become unapplicable.Higher vocational colleges can greatly improve the management level by promoting the informatization of education management according to their own professional or regional advantages.
基金supported by CAMS Innovation Fund for Medical Sciences(No.2021-12M-1-030)the Natural Science Foundation of Beijing Municipality(No.7202131)Chinese Pharmaceutical Association-Yiling Pharmaceutical Innovation Fund for Biomedicine(No.GL-1-B04-20190397)。
文摘We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose consumption in L6 myotubes,taking 1 as the lead.In high-fat diet(HFD)and STZ induced diabetic mice,9a significantly lowers blood glucose,improves glucose tolerance,and especially alleviates diabetic nephropathy and islet damage.Mechanism study indicates that 9a simultaneously targets mitochondrial complex I to increase AMP/ATP ratio,as well as liver kinase B1(LKB1)and calcium/calmodulindependent protein kinase(Ca MKK),which synergistically activates AMPKαand then stimulates glucose transporter 4(GLUT4)membrane translocation and 2-deoxyglucose(2-DG)uptake to exert anti-diabetic efficacy.Therefore,compound 9a with a novel structure is a promising anti-diabetic candidate with the advantage of multiple-target mechanism,worthy of further investigation.
