Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit model...Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10^6 human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.展开更多
Telemetric monitoring and control are the two critical aspects for a robot-rat. Development in this work is a telemetric system to record the electroencephalogram （EEG） from adult freely roaming animals. The system ...Telemetric monitoring and control are the two critical aspects for a robot-rat. Development in this work is a telemetric system to record the electroencephalogram （EEG） from adult freely roaming animals. The system consists of two separated components： the transmit-end system, which consists of the preamplifier, the LPF （low-pass filter） and the transmitter, and the receive-end system, which consists of the receiver, the interface of receive-end and PC. The transmit-end system with light weight （10 g including battery） and small size （20 mm×50 mm） is fettered on the back of the rat. The EEG signal is modulated at the RF frequency of 2.4 GHz by nRF24E1 and transmitted by the antenna. The system can measure the EEG signal of the rat in freely roaming over a wireless transmission distance up to 8 m, and provide a new platform for behavioral and neurophysiological experiments.展开更多
基金supported by a grant from Science and Technology Development Program of Jilin Province of China,No.20110492
文摘Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10^6 human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.
基金supported by the National Natural Science Foundation of China under Grant No. 30870655 and 30570474.
文摘Telemetric monitoring and control are the two critical aspects for a robot-rat. Development in this work is a telemetric system to record the electroencephalogram （EEG） from adult freely roaming animals. The system consists of two separated components： the transmit-end system, which consists of the preamplifier, the LPF （low-pass filter） and the transmitter, and the receive-end system, which consists of the receiver, the interface of receive-end and PC. The transmit-end system with light weight （10 g including battery） and small size （20 mm×50 mm） is fettered on the back of the rat. The EEG signal is modulated at the RF frequency of 2.4 GHz by nRF24E1 and transmitted by the antenna. The system can measure the EEG signal of the rat in freely roaming over a wireless transmission distance up to 8 m, and provide a new platform for behavioral and neurophysiological experiments.
