Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood...Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood glucose,but protect the myocardium by reducing inflammation,oxidative stress and cell apoptosis.Since doxorubicininduced cardiac injury is currently thought to be mainly caused by inflammation,oxidative stress and cell apoptosis,we hypothesized that prophylactic treatment with exenatide may alleviate doxorubicin-induced cardiac injury.展开更多
Large earthquakes not only directly damage buildings but also trigger debris fows,which cause secondary damage to buildings,forming a more destructive earthquake-debris fow disaster chain.A quantitative assessment of ...Large earthquakes not only directly damage buildings but also trigger debris fows,which cause secondary damage to buildings,forming a more destructive earthquake-debris fow disaster chain.A quantitative assessment of building vulnerability is essential for damage assessment after a disaster and for pre-disaster prevention.Using mechanical analysis based on pushover,a physical vulnerability assessment model of buildings in the earthquake-debris fow disaster chain is proposed to assess the vulnerability of buildings in Beichuan County,China.Based on the specifc sequence of events in the earthquake-debris fow disaster chain,the seismic vulnerability of buildings is 79%,the fow impact and burial vulnerabilities of damaged buildings to debris fow are 92%and 28%respectively,and the holistic vulnerability of buildings under the disaster chain is 57%.By comparing diferent vulnerability assessment methods,we observed that the physical vulnerability of buildings under the disaster chain process is not equal to the statistical summation of the vulnerabilities to independent hazards,which implies that the structural properties and vulnerability of buildings have changed during the disaster chain process.Our results provide an integrated explanation of building vulnerability,which is essential for understanding building vulnerability in earthquake-debris fow disaster chain and building vulnerability under other disaster chains.展开更多
文摘Objective Doxorubicin(Dox)is an effective antitumor drug,which is limited due to its lethal cardiac injury in clinical application.Exenatide(Exe)is a glucagon-like peptide-1(GLP-1)analog,it can not only regulate blood glucose,but protect the myocardium by reducing inflammation,oxidative stress and cell apoptosis.Since doxorubicininduced cardiac injury is currently thought to be mainly caused by inflammation,oxidative stress and cell apoptosis,we hypothesized that prophylactic treatment with exenatide may alleviate doxorubicin-induced cardiac injury.
基金The Second Tibetan Plateau Scientifc Expedition and Research Program(STEP,Grant No.2019QZKK0906)the National Key Research and Development Project(Research and demonstration of key technologies for comprehensive prevention of multiple major natural disasters in metropolitan areas,Grant No.2017YFC1503000)jointly supported this work.We thank the Beichuan National Earthquake Ruins Museum for their support。
文摘Large earthquakes not only directly damage buildings but also trigger debris fows,which cause secondary damage to buildings,forming a more destructive earthquake-debris fow disaster chain.A quantitative assessment of building vulnerability is essential for damage assessment after a disaster and for pre-disaster prevention.Using mechanical analysis based on pushover,a physical vulnerability assessment model of buildings in the earthquake-debris fow disaster chain is proposed to assess the vulnerability of buildings in Beichuan County,China.Based on the specifc sequence of events in the earthquake-debris fow disaster chain,the seismic vulnerability of buildings is 79%,the fow impact and burial vulnerabilities of damaged buildings to debris fow are 92%and 28%respectively,and the holistic vulnerability of buildings under the disaster chain is 57%.By comparing diferent vulnerability assessment methods,we observed that the physical vulnerability of buildings under the disaster chain process is not equal to the statistical summation of the vulnerabilities to independent hazards,which implies that the structural properties and vulnerability of buildings have changed during the disaster chain process.Our results provide an integrated explanation of building vulnerability,which is essential for understanding building vulnerability in earthquake-debris fow disaster chain and building vulnerability under other disaster chains.
