A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corre...A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results （up to 〉99% conversion, 〉99% ee and TON up to 200 000）. DFT calculations suggest an activating model involving an alkali cation Li.展开更多
Pd-catalyzed carbonylation,as an efficient synthetic approach to the installation of carbonyl groups in organic compounds,has been one of the most important research fields in the past decade.Although elegant reaction...Pd-catalyzed carbonylation,as an efficient synthetic approach to the installation of carbonyl groups in organic compounds,has been one of the most important research fields in the past decade.Although elegant reactions that allow highly selective carbonylations have been developed,straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical applications.Here,we show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcohols and dioxgen as the carbonyl sources.A broad range of aryl iodides and alcohols are compatible with this protocol.The reaction is concise and practical due to the ready availability of the starting materials and the scalability of the reaction.In addition,the reaction affords lactones and lactams in an intermolecular fashion.Moreover,DFT calculations have been performed to study the detailed mechanisms.展开更多
文摘A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results （up to 〉99% conversion, 〉99% ee and TON up to 200 000）. DFT calculations suggest an activating model involving an alkali cation Li.
基金supported by the Science Foundation for Distinguished Young Scholars for Guangdong Province(2020B1515020026)the Science and Technology Program of Guangzhou(202103000089)+6 种基金the Innovation Team Project of Universities in Guangdong Province(2020KCXTD009)the Scientific Research Projects for Key Disciplines of Guangdong Province(2019-GDXK-0009)the Key Projects of Social Welfare and Basic Research of Zhongshan City(2020B2007)the Innovation and Strong School Project of Guangdong Pharmaceutical University(2018KQNCX131)Guangdong Cosmetics Engineering&Technology Research CenterProvincial Experimental Teaching Demonstration Center of Chemistry&Chemical EngineeringSpecial Funds of Key Disciplines Construction from Guangdong and Zhongshan Cooperating。
文摘Pd-catalyzed carbonylation,as an efficient synthetic approach to the installation of carbonyl groups in organic compounds,has been one of the most important research fields in the past decade.Although elegant reactions that allow highly selective carbonylations have been developed,straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical applications.Here,we show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcohols and dioxgen as the carbonyl sources.A broad range of aryl iodides and alcohols are compatible with this protocol.The reaction is concise and practical due to the ready availability of the starting materials and the scalability of the reaction.In addition,the reaction affords lactones and lactams in an intermolecular fashion.Moreover,DFT calculations have been performed to study the detailed mechanisms.
