Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting re...Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after SCI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.展开更多
基金supported by National Institute of Neurological Disorders and Stroke(NINDS)R01NS091582,NINDS T32 NS077889,and NINDS F31 NS105443。
文摘Spinal cord injury(SCI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain barrier.While these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after SCI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.
