An efficient Synthesis of 5, 9, 13-trimethy1-2-isopropyl-12(S),13 (S)-epoxy-14-bromo-2 (Z), 4 (E). 8 (E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcop...An efficient Synthesis of 5, 9, 13-trimethy1-2-isopropyl-12(S),13 (S)-epoxy-14-bromo-2 (Z), 4 (E). 8 (E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C,was first describedthrough seven step sequence in-32% overall yield from E,E-farnesol.展开更多
文摘An efficient Synthesis of 5, 9, 13-trimethy1-2-isopropyl-12(S),13 (S)-epoxy-14-bromo-2 (Z), 4 (E). 8 (E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C,was first describedthrough seven step sequence in-32% overall yield from E,E-farnesol.
