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克唑替尼对ALK阳性NSCLC患者CNS的影响 被引量:1
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作者 焦婷 李京云 梁月勉 《中国现代医学杂志》 CAS 2018年第23期83-86,共4页
目的探讨克唑替尼对间变性淋巴瘤激酶(ALK)阳性非小细胞肺癌(NSCLC)患者中枢神经系统(CNS)的影响。方法回顾性分析在河北大学附属医院接受治疗的59例ALK阳性NSCLC患者的临床资料,应用荧光原位杂交、逆转录聚合酶链反应或免疫组织化学法... 目的探讨克唑替尼对间变性淋巴瘤激酶(ALK)阳性非小细胞肺癌(NSCLC)患者中枢神经系统(CNS)的影响。方法回顾性分析在河北大学附属医院接受治疗的59例ALK阳性NSCLC患者的临床资料,应用荧光原位杂交、逆转录聚合酶链反应或免疫组织化学法评估ALK基因重组的状态,利用实体肿瘤反应评估标准客观评估肿瘤情况。结果患者克唑替尼的客观缓解率为66%,无进展生存期中值为9.7个月。24例患者中CNS是常见的初始进展位点,18例患者有单独的CNS进展。BM阳性与阴性的患者的无进展生存率比较有差异(P<0.05)。多变量分析显示,较差的体能状态(脑转移≥2)或未治疗的BM阳性患者与PFS有关(P<0.05)。给予克唑替尼治疗后26个月,BM阳性与阴性患者CNS进展发生率比较有差异(P<0.05)。结论克唑替尼治疗的ALK阳性患者中,常见进展部位是CNS,其进展与低渗透性有关。 展开更多
关键词 非小细胞肺癌 克唑替尼 ALK重组
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High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing 被引量:8
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作者 Yongxia YAO Wei QIN +3 位作者 Bohang XING Na SHA ting jiao Zhe ZHAO 《Journal of Advanced Ceramics》 SCIE CAS CSCD 2021年第1期39-48,共10页
High performance hydroxyapatite(HA)ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing(DLP)three-dimensional(3D)printing technology.It was found tha... High performance hydroxyapatite(HA)ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing(DLP)three-dimensional(3D)printing technology.It was found that the sintering atmosphere of wet C02 can dramatically improve the densification process and thus lead to better mechanical properties.HA ceramics with a relative density of 97.12%and a three-point bending strength of 92.4 MPa can be achieved at a sintering temperature of 1300℃,which makes a solid foundation for application in bone engineering.Furthermore,a relatively high compressive strength of 4.09 MPa can be also achieved for a DLP-printed p-cell triply periodic minimum surface(TPMS)structure with a porosity of 74%,which meets the requirement of cancellous bone substitutes.A further cell proliferation test demonstrated that the sintering atmosphere of wet CO2 led to improve cell vitality after 7 days of cell culture Moreover,with the possible benefit from the bio-inspired structure,the 3D-printed TPMS structure significantly improved the cell vitality,which is crucial for early osteogenesis and osteointegration. 展开更多
关键词 hydroxyapatite(HA) 3D printing sintering atmosphere mechanical property bioactivity digital light processing(DLP)
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Queue reduction in discrete-event systems by relabeling 被引量:1
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作者 Yongmei GAN ting jiao W. M. WONHAM 《Control Theory and Technology》 EI CSCD 2018年第3期232-240,共9页
The customer population of entities potentially requesting to join a queue for service often have identical structure, i.e., the same state set and isomorphic transitions. The state size of the automaton modeling a qu... The customer population of entities potentially requesting to join a queue for service often have identical structure, i.e., the same state set and isomorphic transitions. The state size of the automaton modeling a queue will grow rapidly with increase of the size of this population. However, by relabeling the queue arrival events and service events to the same symbols respectively, the automaton model of a queue will be converted to the structure of a buffer, which is proved to be independent of the total size of the customer population, as long as the queue size is held fixed. We propose the model of a dynamic buffer to embody order and shift of a queue. The result is applied to a manufacturing facility with a dynamic buffer to manage the repair of broken down machines. 展开更多
关键词 QUEUE relabeling identical structures invariance property discrete-event systems
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