The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the“brain-oral axis”.A deeper understa...The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the“brain-oral axis”.A deeper understanding of the intricate interaction between the nervous system and the stomatognathic system is warranted,considering their significant developmental homology and anatomical proximity,and the more complex innervation of the jawbone compared to other skeletons.In this review,we provide an in-depth look at studies concerning neurodevelopment,craniofacial development,and congenital anomalies that occur when the two systems develop abnormally.It summarizes the cross-regulation between nerves and jawbones and the effects of various states of the jawbone on intrabony nerve distribution.Diseases closely related to both the nervous system and the stomatognathic system are divided into craniofacial diseases caused by neurological illnesses,and neurological diseases caused by an aberrant stomatognathic system.The two-way relationships between common diseases,such as periodontitis and neurodegenerative disorders,and depression and oral diseases were also discussed.This review provides valuable insights into novel strategies for neuro-skeletal tissue engineering and early prevention and treatment of orofacial and neurological diseases.展开更多
BACKGROUND Erythropoiesis-stimulating agents(ESAs)have revolutionized the therapeutic strategy for anemia in chronic kidney disease.However,some cases are resistant or hyporesponsive to ESAs.Roxadustat is an oral hypo...BACKGROUND Erythropoiesis-stimulating agents(ESAs)have revolutionized the therapeutic strategy for anemia in chronic kidney disease.However,some cases are resistant or hyporesponsive to ESAs.Roxadustat is an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism.Here,we describe a hemodialysis patient with refractory anemia who did not respond to traditional treatments and depended on blood transfusion for more than 1 year.After applying Roxadustat,the patient’s anemia improved significantly.CASE SUMMARY A 44-year-old man was diagnosed with uremia accompanied by severe anemia with a hemoglobin(Hb)level ranging from 30-40 g/L.His anemia did not improve after sufficient dialysis or high doses of active ESAs;other causes of anemia were excluded.The patient required approximately 600-1000 mL of red blood cell suspension every 15-30 d for more than 1 year.After accepting Roxadustat therapy,the patient’s anemia symptoms improved significantly;his Hb level gradually increased to 50 g/L,and no further blood transfusions were administered.His Hb level reached 69 g/L by the 34th week.Although a Hb level of 60-70 g/L cannot be considered satisfactory,he no longer required blood transfusions and his quality of life was substantially improved.Roxadustat showed good efficacy and safety in this case.CONCLUSION Roxadustat represents an innovative and effective agent for the clinical treatment of renal anemia caused by multiple complex factors.展开更多
In this paper, quartz crystal microbalance(QCM) gas sensors coated with polyehtyleneimine(PEI)was utilized for carbon dioxide(CO2) detection. The sensing mechanism is based on the availability of reversible acid-base ...In this paper, quartz crystal microbalance(QCM) gas sensors coated with polyehtyleneimine(PEI)was utilized for carbon dioxide(CO2) detection. The sensing mechanism is based on the availability of reversible acid-base reactions between CO2 molecules and PEI at room temperature. The experimental results revealed that the PEI/starch sensor exhibited much higher sensitivity than that of pure PEI, and showed approximate linearity over a concentration region ranging from 500 ppm to 8000 ppm. The influence of humidity had also been investigated. Furthermore, the response and recovery time deceased as the operation temperatures increased. Finally, sensitivity loss after conservation for several days and reversibility of the sensors had been discussed.展开更多
[Objectives]To establish an ultra performance convergence chromatography(UPC2)method to determine the content of enantiomers in(R)-2-methoxyethyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride(ET-26 HCl).[M...[Objectives]To establish an ultra performance convergence chromatography(UPC2)method to determine the content of enantiomers in(R)-2-methoxyethyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride(ET-26 HCl).[Methods]ChiralpakAD-3 chromatographic column(4.6 mm×100 mm,3μm)was used,with 0.1%diethylamine methanol solution-supercritical carbon dioxide(1∶9)as mobile phase;flow rate 2.0 mL/min;back pressure 2000 psi,detection wavelength 240 nm,and column temperature 35℃.[Results]ET-26-HCl was completely separated from the enantiomers,and the linear relationship was good;the detection limit was 1.5μg/mL.[Conclusions]This method is suitable for the determination of the content of enantiomers in ET-26-HCl.展开更多
The morphologies of CuO/CeO_(2)-ZrO_(2) catalysts were successfully controlled by simply changing the synthesis temperature using hydrothermal method.The catalytic performance for toluene oxidation was correlated with...The morphologies of CuO/CeO_(2)-ZrO_(2) catalysts were successfully controlled by simply changing the synthesis temperature using hydrothermal method.The catalytic performance for toluene oxidation was correlated with the characterization results of HRTEM,BET,XRD,H2-TPR,Raman,and O_(2)-TPD.It was found that toluene can be oxidized into CO_(2) and H2O completely over the obtained catalysts,and the rod-like Cu/Ce-Zr-100 exhibits the best activity and CO_(2) selectivity.The rod-like CeO_(2)-ZrO_(2) supports preferentially exposes(110)and(100)crystal planes of CeO_(2),which provides more oxygen vacancies and stronger interaction between CuO and the support in Cu/Ce-Zr-100.And the strong synergetic effect in Cu/Ce-Zr-100 promotes the dispersion of CuO on the support surface,leading to the enhancement of reducibility,oxygen vacancy concentration,adsorption and activation of gaseous oxygen,which are responsible for the good catalytic performance of toluene oxidation.展开更多
In this paper,the dynamic behaviors are studied for a stochastic delayed avian influenza model with mutation and temporary immunity.First,we prove the existence and uniqueness of the global positive solution for the s...In this paper,the dynamic behaviors are studied for a stochastic delayed avian influenza model with mutation and temporary immunity.First,we prove the existence and uniqueness of the global positive solution for the stochastic model.Second,we give two different thresholds R_(01)^(s) and,R_(02)^(s) and further establish the sufficient conditions of extinction and persistence in the mean for the avian-only subsystem and avian-human system,respectively.Compared with the corresponding deterministic model,the thresholds affected by the white noises are smaller than the ones of the deterministic system.Finally,numerical simulations are carried out to support our theoretical results.It is concluded that the vaccination immunity period can suppress the spread of avian influenza during poultry and human populations,while prompt the spread of mutant avian influenza in human population.展开更多
基金supported by the Key Research and Development Program in Zhejiang Province(No.2021C03059)the Funds of the Central Government Guiding Local Science and Technology Development(No.2023ZY1060)National Natural Science Foundation of China(No.81801011).
文摘The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the“brain-oral axis”.A deeper understanding of the intricate interaction between the nervous system and the stomatognathic system is warranted,considering their significant developmental homology and anatomical proximity,and the more complex innervation of the jawbone compared to other skeletons.In this review,we provide an in-depth look at studies concerning neurodevelopment,craniofacial development,and congenital anomalies that occur when the two systems develop abnormally.It summarizes the cross-regulation between nerves and jawbones and the effects of various states of the jawbone on intrabony nerve distribution.Diseases closely related to both the nervous system and the stomatognathic system are divided into craniofacial diseases caused by neurological illnesses,and neurological diseases caused by an aberrant stomatognathic system.The two-way relationships between common diseases,such as periodontitis and neurodegenerative disorders,and depression and oral diseases were also discussed.This review provides valuable insights into novel strategies for neuro-skeletal tissue engineering and early prevention and treatment of orofacial and neurological diseases.
基金Sichuan Clinical Research Center for Nephropathy,No.2019YFS0537-3.
文摘BACKGROUND Erythropoiesis-stimulating agents(ESAs)have revolutionized the therapeutic strategy for anemia in chronic kidney disease.However,some cases are resistant or hyporesponsive to ESAs.Roxadustat is an oral hypoxia-inducible factor-prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism.Here,we describe a hemodialysis patient with refractory anemia who did not respond to traditional treatments and depended on blood transfusion for more than 1 year.After applying Roxadustat,the patient’s anemia improved significantly.CASE SUMMARY A 44-year-old man was diagnosed with uremia accompanied by severe anemia with a hemoglobin(Hb)level ranging from 30-40 g/L.His anemia did not improve after sufficient dialysis or high doses of active ESAs;other causes of anemia were excluded.The patient required approximately 600-1000 mL of red blood cell suspension every 15-30 d for more than 1 year.After accepting Roxadustat therapy,the patient’s anemia symptoms improved significantly;his Hb level gradually increased to 50 g/L,and no further blood transfusions were administered.His Hb level reached 69 g/L by the 34th week.Although a Hb level of 60-70 g/L cannot be considered satisfactory,he no longer required blood transfusions and his quality of life was substantially improved.Roxadustat showed good efficacy and safety in this case.CONCLUSION Roxadustat represents an innovative and effective agent for the clinical treatment of renal anemia caused by multiple complex factors.
基金supported by the National Natural Science Foundation of China under Grant No.61176006 and No.61006036the Specialized Research Fund for the Doctoral Program of Higher Education under Grant No.20120185110012
文摘In this paper, quartz crystal microbalance(QCM) gas sensors coated with polyehtyleneimine(PEI)was utilized for carbon dioxide(CO2) detection. The sensing mechanism is based on the availability of reversible acid-base reactions between CO2 molecules and PEI at room temperature. The experimental results revealed that the PEI/starch sensor exhibited much higher sensitivity than that of pure PEI, and showed approximate linearity over a concentration region ranging from 500 ppm to 8000 ppm. The influence of humidity had also been investigated. Furthermore, the response and recovery time deceased as the operation temperatures increased. Finally, sensitivity loss after conservation for several days and reversibility of the sensors had been discussed.
文摘[Objectives]To establish an ultra performance convergence chromatography(UPC2)method to determine the content of enantiomers in(R)-2-methoxyethyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride(ET-26 HCl).[Methods]ChiralpakAD-3 chromatographic column(4.6 mm×100 mm,3μm)was used,with 0.1%diethylamine methanol solution-supercritical carbon dioxide(1∶9)as mobile phase;flow rate 2.0 mL/min;back pressure 2000 psi,detection wavelength 240 nm,and column temperature 35℃.[Results]ET-26-HCl was completely separated from the enantiomers,and the linear relationship was good;the detection limit was 1.5μg/mL.[Conclusions]This method is suitable for the determination of the content of enantiomers in ET-26-HCl.
基金the financial support from the National Natural Science Foundation of China(No 51776216)the Postdoctoral Science Foundation of China(No.2017 M623284).
文摘The morphologies of CuO/CeO_(2)-ZrO_(2) catalysts were successfully controlled by simply changing the synthesis temperature using hydrothermal method.The catalytic performance for toluene oxidation was correlated with the characterization results of HRTEM,BET,XRD,H2-TPR,Raman,and O_(2)-TPD.It was found that toluene can be oxidized into CO_(2) and H2O completely over the obtained catalysts,and the rod-like Cu/Ce-Zr-100 exhibits the best activity and CO_(2) selectivity.The rod-like CeO_(2)-ZrO_(2) supports preferentially exposes(110)and(100)crystal planes of CeO_(2),which provides more oxygen vacancies and stronger interaction between CuO and the support in Cu/Ce-Zr-100.And the strong synergetic effect in Cu/Ce-Zr-100 promotes the dispersion of CuO on the support surface,leading to the enhancement of reducibility,oxygen vacancy concentration,adsorption and activation of gaseous oxygen,which are responsible for the good catalytic performance of toluene oxidation.
基金The research was supported by Ningxia Natural Science Foundation Project(2019AAC03069).
文摘In this paper,the dynamic behaviors are studied for a stochastic delayed avian influenza model with mutation and temporary immunity.First,we prove the existence and uniqueness of the global positive solution for the stochastic model.Second,we give two different thresholds R_(01)^(s) and,R_(02)^(s) and further establish the sufficient conditions of extinction and persistence in the mean for the avian-only subsystem and avian-human system,respectively.Compared with the corresponding deterministic model,the thresholds affected by the white noises are smaller than the ones of the deterministic system.Finally,numerical simulations are carried out to support our theoretical results.It is concluded that the vaccination immunity period can suppress the spread of avian influenza during poultry and human populations,while prompt the spread of mutant avian influenza in human population.
