Pectolinarin inhibited LPS-stimulated inflammation in microglial BV_(2) cells via NF-κB signaling pathway

Background:Neuro-inflammation is regarded as one of the critical pathogenesis in neurodegenerative diseases,which is characterized by the activated microglial cells.Pectolinarin(Pec),a natural flavonoid that exists in many Chinese herbal medicines,has been reported to have various biological activities.However,the effects and mechanisms on neuro-inflammation are not clear.Methods:In this study,the inhibitory effects and mechanisms of Pec on neuro-inflammation were investigated in the LPS-stimulated microglial BV_(2) cells.BV_(2) microglial cells were treated with Pec or vehicle,followed by LPS.Enzyme-linked immunosorbent assay,real-time quantitative PCR,nitric oxide and reactive oxygen species assay,and western blot were performed to examine the effects of Pec on neuro-inflammatory responses.Results:We showed that Pec significantly inhibited the expression of tumor necrosis factorαand interleukin 6 in mRNA and protein levels induced by LPS.Moreover,the production of nitric oxide,iNOS,reactive oxygen species,and COX-2 were suppressed by Pec in LPS-stimulated microglial BV_(2) cells.In addition,Pec inhibited LPS-induced inflammation via nuclear factor kappa B signaling pathway,as evidenced by the reduction of the phosphorylation of inhibitor of nuclear factor kappa-B kinase,the degradation of IκBα,and the nuclear translocation of p65.Conclusion:Taken together,Pec exhibited anti-inflammatory effects in LPS-stimulated microglial BV_(2) cells via nuclear factor kappa B signaling pathway,which might provide therapeutic potential for neuro-inflammation and neurodegenerative diseases.

退役军人事务领域财政事权和支出责任划分研究——以H市为例

H市退役军人事务领域财政事权和支出责任划分影响到该市两级政府能否协同提供高质量退役军人保障服务。论文在理论分析维度上选取外部性、信息复杂性和激励相容作为退役军人事务领域财政事权和支出责任划分的规则。在效果评估维度上,立于政策安排、数据分析及实地调研三个层面,研究发现,各类划分政策呈现粗线条、碎片化的特征。H市总体上、分领域财政事权、核心财政事项的划分结果显示,表现不佳的退役安置、抚恤优待、褒扬激励中仅抚恤优待的状况有所改善,表现较好的教育培训与就业创业、总体财政事权的状况略微改进,而服务管理的状况有所退化;调研结果反映出部分退役军人事务事项的各级财政分担不合理,区级财政负担过重,资金保障不足,划分错位问题较为明显。在政策建议维度上,论文提出退役军人事务领域财政事权和支出责任划分改革方案及拟定具体划分清单。研究可为H市先行先试退役军人事务领域财政事权和支出责任划分改革提供参考,也可为同类地方政府以及央地间的此类改革设计提供启示。

Analysis of Climatic Factors Influencing Walnut Distribution in the Main Producing Areas of Yunnan Province

Using the data of 11 climatic factors on 40 counties in the main producing areas of walnut of Yunnan Province,we analyze the impact of various climatic factors on the distribution of Yunnan walnut.The results show that Yunnan walnut has a great expectation on temperature and moisture.Temperature,including average temperature in January,average temperature in July,the average annual temperature and accumulated temperature≥10℃,has the greatest impact on the distribution of Yunnan walnut,and is the primary dominant factor;moisture,including annual rainfall and average relative humidity,has a great impact on the distribution of Yunnan walnut,and is the secondary dominant factor.

UltraStar:A Lightweight Simulator of Ultra-Dense LEO Satellite Constellation Networking for 6G

The mega-constellation network has gained significant attention recently due to its great potential in providing ubiquitous and high-capacity connectivity in sixth-generation(6G)wireless communication systems.However,the high dynamics of network topology and large scale of mega-constellation pose new challenges to the constellation simulation and performance evaluation.In this paper,we introduce UltraStar,a lightweight network simulator,which aims to facilitate the complicated simulation for the emerging mega-constellation of unprecedented scale.Particularly,a systematic and extensible architecture is proposed,where the joint requirement for network simulation,quantitative evaluation,data statistics and visualization is fully considered.For characterizing the network,we make lightweight abstractions of physical entities and models,which contain basic representatives of networking nodes,structures and protocol stacks.Then,to consider the high dynamics of Walker constellations,we give a two-stage topology maintenance method for constellation initialization and orbit prediction.Further,based on the discrete event simulation(DES)theory,a new set of discrete events is specifically designed for basic network processes,so as to maintain network state changes over time.Finally,taking the first-generation Starlink of 11927 low earth orbit(LEO)satellites as an example,we use UltraStar to fully evaluate its network performance for different deployment stages,such as characteristics of constellation topology,performance of end-to-end service and effects of network-wide traffic interaction.The simulation results not only demonstrate its superior performance,but also verify the effectiveness of UltraStar.

Designing Advanced Liquid Electrolytes for Alkali Metal Batteries:Principles,Progress,and Perspectives

The ever-growing pursuit of high energy density batteries has triggered extensive efforts toward developing alkali metal(Li,Na,and K)battery(AMB)technologies owing to high theoretical capacities and low redox potentials of metallic anodes.Typically,for new battery systems,the electrolyte design is critical for realizing the battery electrochemistry of AMBs.Conventional electrolytes in alkali ion batteries are generally unsuitable for sustaining the stability owing to the hyper-reactivity and dendritic growth of alkali metals.In this review,we begin with the fundamentals of AMB electrolytes.Recent advancements in concentrated and fluorinated electrolytes,as well as functional electrolyte additives for boosting the stability of Li metal batteries,are summarized and discussed with a special focus on structure-composition-performance relationships.We then delve into the electrolyte formulations for Na-and K metal batteries,including those in which Na/K do not adhere to the Li-inherited paradigms.Finally,the challenges and the future research needs in advanced electrolytes for AMB are highlighted.This comprehensive review sheds light on the principles for the rational design of promising electrolytes and offers new inspirations for developing stable AMBs with high performance.

Problems and Strategies of English Teaching in Rural Middle Schools in the Era of New Media

With the deepening of curriculum reform in junior high school,the education field is undergoing tremendous changes.Besides,with the rapid development of the Internet today,students have been exposed to various new media software since childhood.The existing education and teaching are also desperately keeping up with the pace of the times,and continue to bring online teaching to the practical classrooms of rural middle schools through new media.Teachers should not only impart basic professional knowledge to students,but also improve students'ability to use English.

Design and Data Analysis of a New Type of Antifreezing Cup-Type Wind Velocity Sensor

In most areas of China, affected by the environment of low temperature and high humidity, the wind speed sensor and wind direction sensor are frozen and cannot output data in autumn, winter or the alternation of winter and spring. In order to solve the freezing situation of the wind sensor, this paper designs a new type of antifreeze wind speed sensor. After meteorology performance testing and field observation tests, the correlation coefficient of the observation data is demonstrated, and the data curve is fitted. The result shows the sensor is stable, and has a good antifreeze effect, the data output is reliable.

单眼和双眼Symfony人工晶状体植入术后生活质量的比较

目的:比较接受双眼Symfony连续视程人工晶状体(intraocular lens, IOL)植入与接受单眼Symfony连续视程IOL植入而另一眼非球面单焦点IOL植入患者术后的生活质量。方法:采用以人群为基础的横断面研究。以美国国家眼科研究所研制开发的视功能调查问卷(the National Eye Institute Visual Functioning Questionnaire-25,NEI VFQ-25)对研究对象的术后视功能相关生活质量(vision-related quality of life,vision-related QoL)进行评价。收集2017-03/2018-03行白内障超声乳化吸除联合IOL植入术的患者30例60眼,按照植入IOL类型分为两组,双眼植入TECNIS Symfony连续视程人工晶状体(ZXR00)为双眼组(18例36眼),一眼植入TECNIS Symfony连续视程人工晶状体(ZXR00),另一眼植入非球面单焦点IOL(PCB00)为单眼组(12例24眼)。术后3～6mo进行随访,主要观察指标为双眼远、中、近裸眼视力和生活质量调查问卷。结果:双眼组和单眼组术后双眼裸眼远、中、近视力比较,差异无统计学意义(P> 0. 05)。两组患者术后NEI VFQ-25问卷总评分(88. 95±4. 01 vs 88. 99±4. 22分)比较,差异无统计学意义(t=-0. 025,P=0. 980)。12个维度的评分结果对比显示,两组患者术后与视觉相关的各个方面生活质量差异均无统计学意义(P>0. 05)。结论:双眼植入ZXR00或一眼植入ZXR00,另一眼植入PCB00的患者均具有良好的双眼全程视力。两组患者的术后生活质量无差异。对一眼已行单焦点IOL植入的患者或一眼不适合装多焦点人工晶状体的患者,可行另一眼Symfony连续视程IOL植入以满足患者脱镜需求。

基于云计算的智能电表用户表单隐私保护

智能电力系统的快速发展,对于海量数据的存储及计算的要求越来越高,使其与云计算的结合成为必然。但是接入云计算系统不可避免的带来了数据安全问题。本文针对智能电表系统的用户信息隐私保护,基于数据组合隐私机制,引入可信第三方,运用数据分块存储及分块关系混淆技术保护智能电表系统的用户隐私。并提出分块信息表单系统,在分块存储环境下实现数据插入与数据查询。

玻璃体切割术后超声乳化联合人工晶状体植入术的屈光误差分析

目的:探讨玻璃体切割术后白内障患者Ⅱ期行白内障超声乳化抽吸联合人工晶状体(IOL)植入的屈光误差。方法:回顾性分析。选取既往行玻璃体切割术现发生白内障需行手术治疗的患者38例40眼。按既往玻璃体腔填充物分为2组,A组(22眼)为既往单纯行玻璃体切割组,B组(18眼)为既往行玻璃体切割联合惰性气体(C_(3)F_(8))填充组。另设置无玻璃体切割手术史现需行白内障超声乳化抽吸手术的正常对照组C组(20眼)。术前应用IOL Master 500测量眼轴长度(AL)、角膜曲率(K)、前房深度(ACD),角膜横径(W-W),带入Barrett UniversalⅡ公式计算IOL屈光度。A组、B组采用虹膜拉钩辅助的超声乳化抽吸联合IOL植入术,C组为单纯超声乳化抽吸联合IOL植入术。术中均无后囊膜破裂等并发症。术后3mo验光获得实测屈光度。比较3组的预测误差、绝对预测误差、绝对误差中位数。结果:三组间AL、K、植入IOL屈光度数均无差异(P>0.05)。A组、B组ACD均较C组显著加深(P<0.01)。三组间预测误差有差异(P=0.042),B组较C组有显著的远视漂移。绝对预测误差、绝对误差中位数在组间无差异。结论:单纯玻璃体切割术后Ⅱ期白内障超声乳化联合IOL植入,与正常对照组相比,术后屈光结果无显著差异;但在玻璃体切割联合惰性气体填充术后患者,Ⅱ期白内障超声乳化抽吸术后会产生远视漂移,在选择IOL时应避免欠矫,适当过矫。

糖尿病病程对合并糖尿病的白内障患者眼表的影响

目的:观察不同糖尿病病程对白内障患者术前干眼及眼表的影响。方法:观察我院2018-03/08合并糖尿病的白内障患者眼表及干眼情况。按照糖尿病病程分组,分为<5a,5～15a,>15a三个组。比较三组患者年龄、性别、泪膜破裂时间(break-up time,BUT),Schirmer I试验,角膜荧光染色(fluorescein cornea staining,FL),睑缘形态、睑板腺分泌功能以及眼表疾病评分量表(OSDI)。结果:三组患者年龄、性别差异均无统计学意义。三组间BUT和SchirmerⅠ及OSDI评分差异均无统计学意义,但随着糖尿病病程的延长,OSDI评分逐渐增加。FL和睑板腺分泌在不同病程组比较差异有统计学意义(χ~2=8. 372、9. 346,P=0. 015、0. 009),睑缘形态差异无统计学意义(χ~2=0. 353,P=0. 838)。结论:随着糖尿病病程延长,合并糖尿病的白内障患者眼表及干眼病可能更加严重。对于长期糖尿病患者白内障手术围手术期,需要更加关注眼表的健康及恢复情况。

双焦点及散光双焦点人工晶状体混搭植入术后双眼视觉质量的研究

目的:研究散光矫正型双焦点人工晶状体与双焦点人工晶状体混搭植入术后的双眼视觉质量。方法:横断面研究。纳入2020-01/2021-01收治的年龄相关性白内障患者54例108眼,按植入人工晶状体及术前角膜散光不同分为3组,A组21例42眼术前角膜散光均<1.0D,双眼植入双焦点人工晶状体;B组15例30眼术前角膜散光均≥1.0D,双眼植入散光双焦点人工晶状体;C组18例36眼,一眼术前角膜散光<1.0D,另一眼术前角膜散光≥1.0D,前者植入双焦点人工晶状体,后者植入散光双焦点人工晶状体。比较三组患者术前单眼视力,术后双眼视力、残余散光、双眼离焦曲线、对比敏感度(CS),三组患者术后进行问卷调查评估视觉质量。结果:三组患者术前视力、术前眼压均无差异(P>0.05)。A组术后残余散光显著高于另两组(P=0.012,<0.05)。B组和C组双眼远视力优于A组(均P<0.05);B组和C组双眼近视力优于A组(均P<0.01);A组双眼中视力优于B组和C组(均P<0.01)。明视眩光6、12c/d,暗视6、12、18c/d,以及暗视眩光1.5、3、6、12、18c/d的空间频率下A组CS较B组和C组显著降低(均P<0.05)。术后视功能调查表三组间无差异(P>0.05)。结论:散光双焦人工晶状体与双焦人工晶状体混搭植入可改善患者术后视觉质量。矫正散光有助于提高术后患者的视觉CS,但是散光全矫后,可能会导致患者术后中视力的下降。

COVID-19: Challenges to GIS with Big Data

The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management.

Congenital bronchoesophageal fistula in an adult: A case report

Bronchoesophageal fistulas are usually diagnosed in the neonatal period. As such, the condition is rare in adults. We present a case of a congenital bronchoesophageal fistula in a 62-year-old man with the complaint of severe bouts of cough and choking after swallowing liquid. His workup included a barium esophagogram that revealed a fistula between the esophagus and a right lower lobe bronchus. The diagnosis should be considered in certain individuals with suggestive symptomatology and unexplained respiratory pathology. The fistula was divided and resected, The patient had an uneventful recovery.

Comparison of posterior capsule opacification at 360-degree square edge hydrophilic and sharp edge hydrophobic acrylic intraocular lens in diabetic patients

·AIM: To compare posterior capsule opacification(PCO)degree and visual functions after phacoemulsification in eyes implanted with 360-degree square edge hydrophilic acrylic intraocular lens(IOL)(570C C-flex, Rayner) and sharp edge hydrophobic acrylic IOL(Sensar AR40 e,AMO) in diabetic patients.· METHODS: Sixty diabetic patients underwent uneventful phacoemulsification and randomly implanted one of the two IOLs. The PCO value was measured by retroillumination photographs and Evaluation of Posterior Capsule Opacification(EPCO) 2000 image-analysis software at 1, 6, 12, and 24 mo after surgery. Visual acuity, and contrast sensitivity in photopic and mesopic conditions were also examined at each follow up time point. The incidence of eye that required Nd:YAG laser posterior capsulotomy were also compared.·RESULTS: There was not any statistically significant difference in PCO scores between Rayner C-flex 570 C group and Sensar AR40 e group at each follow up time point. Visual acuity, Nd:YAG capsulotomy incidence and contrast sensitivity also had no significant difference during the 24 mo follow-up.·CONCLUSION: For diabetic patients, Rayner 570 C Cflex and Sensar AR40 e IOLs are same effective for prevent PCO. The 360-degree square edge design maybe is a good alternative technique to improve PCO prevention.

Targeting epigenetic regulators to overcome drug resistance in cancers

Drug resistance is mainly responsible for cancer recurrence and poor prognosis.Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.As the common epigenetic regulation mechanisms,DNA methylation,histone modification,and non-coding RNA regulation have been well studied.Increasing evidence has shown that aberrant epigenetic regulations contribute to tumor resistance.Therefore,targeting epigenetic regulators represents an effective strategy to reverse drug resistance.In this review,we mainly summarize the roles of epigenetic regulation in tumor resistance.In addition,as the essential factors for epigenetic modifications,histone demethylases mediate the histone or genomic DNA modifications.Herein,we comprehensively describe the functions of the histone demethylase family including the lysine-specific demethylase family,the Jumonji C-domain-containing demethylase family,and the histone arginine demethylase family,and fully discuss their regulatory mechanisms related to cancer drug resistance.In addition,therapeutic strategies,including small-molecule inhibitors and small interfering RNA targeting histone demethylases to overcome drug resistance,are also described.

Upper crustal structure under Jingtai–Hezuo profile in Northeastern Tibet from topography-dependent eikonal traveltime tomography

The Northeastern Tibetan plateau records Caledonian Qilian orogeny and Cenozoic reactivation by continental collision between the Indian and Asian plates. In order to provide the constraint on the Qilian orogenic mechanism and the expansion of the plateau,wide-angle seismic data was acquired along a 430 km-long profile between Jingtai and Hezuo. There is strong height variation along the profile,which is dealt by topography flattening scheme in our crustal velocity structure reconstruction. We herein present the upper crustal P-wave velocity structure model resulting from the interpretation of first arrival dataset from topography-dependent eikonal traveltime tomography. With topography flattening scheme to process real topography along the profile,the evenness of ray coverage times of the image area（upper crust）is improved,which provides upper crustal velocity model comparable to the classic traveltime tomography（with model expansion scheme to process irregular surface）. The upper crustal velocity model shows zoning character which matcheswith the tectonic division of the Qaidam-Kunlun-West Qinling belt,the Central and Northern Qilian,and the Alax blocks along the profile. The resultant upper crustal P-wave velocity model is expected to provide important base for linkage between the mapped surface geology and deep structure or geodynamics in Northeastern Tibet.

Unilateral pleural effusion secondary to Takayasu arteritis: a case report and literature review

Takayasu arteritis (TA) is a chronic, nonspecific inflammatory disease of large and medium-sized vessels that primarily involves the aorta and its branches. TA involving the pulmonary arteries has a prevalence ranging from 14% to 86%, which can lead to pulmonary hypertension, a progressive increase in pulmonary artery pressure, and eventually death from right heart failure. The presentation of pulmonary arteritis (PA) is very nonspecific, with a reported misdiagnosis rate of up to 60% and a diagnosis time ranging from 1 month to more than 10 years. The clinical manifestation of pleural effusion is very rare in both TA and PA cases. Based on our literature review, this is the 6th reported case of TA with pleural effusion, and the specific mechanism of TA with pleural effusion is still unclear. The characteristics of this case and the previously reported cases are summarized in this article to improve the understanding of TA and PA and reduce the misdiagnosis rate.

Comparison and Analysis of Data at Traffic Meteorological Observation Station during Beijing Winter Olympic Games Period

This paper presents a comparison and analysis method of data at traffic meteorological observation station during Beijing Winter Olympic Games period based on Grubbs criterion. By comparing the data of a set of standard multi-element observation stations with the data of multiple measured traffic stations, the outliers of each element data at each station were analyzed. It could provide data support for the maintenance of Zhangjiakou traffic meteorological observation station and a guarantee for the accuracy of forest service during Beijing Winter Olympic Games period.

Influence of Laboratory Environment on the Verification Results of EL15-1A Type of Wind Speed Sensor

According to the verification regulation of the Wind Direction and Wind Speed Sensor of Automatic Meteorological Station[JJG(meteorological)004-2011],relying on the wind tunnel laboratory of Hebei meteorological measurement station,EL15-1 A type of wind speed sensor in the automatic weather station was verified.The experimental data of sensor verification in different laboratory environments were obtained through data comparison.Using standard wind speed measurement formula,the influence of laboratory temperature,humidity and air pressure on verification results was analyzed quantitatively.The results showed that laboratory temperature had the greatest influence on the verification results of this type of sensor,while the humidity and air pressure had less influence.Therefore,it should be noted that the temperature change in the laboratory should not be too large in the process of verification,so as to improve the accuracy of the verification results.