The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the...The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the mediating effect of goal self-concordance and self-efficacy,this paper further studies the impact of spiritual leadership on employee’s work engagement.Through the empirical study,the following conclusions are drawn:(1)Spiritual leadership significantly positively affects the employee’s work engagement.(2)Spiritual leadership has a significant positive effect on goal self-concordance and self-efficacy.(3)Goal self-concordance and self-efficacy have significant positive effects on employee’s work engagement.(4)Goal self-concordance and self-efficacy play a partial mediating role in the process of spiritual leadership’s impact on employees’work engagement.This study found the new mediator which partly revealed the mechanism between the effectiveness of Spiritual Leadership and employee’s work engagement.This study may serve as one of the researches for improving the effectiveness of leaders in organizations and promoting the motivation of employees in the workplace.展开更多
Goal self-concordance reflects self-generated personal goals aligning with people’s interests and core values in one’s implicit personality as organic components,which is measured by the“perceived locus of causalit...Goal self-concordance reflects self-generated personal goals aligning with people’s interests and core values in one’s implicit personality as organic components,which is measured by the“perceived locus of causality”PLOC.Pursuing and achieving self-concordant goals both predict diversified outcomes in need-satisfaction,mental and physical well-being,positive attitude and behavior,etc.Based on expounding and sorting out the concept and measurement about goal self-concordance,the author analyzes the differences among a series of goal self-concor-dance theories.This paper focuses on the latest research trends and summarizesfive influencing aspects of goal self-concordance:mental health,cognition,emotion,personal will,and behavioral outcomes.The mediating effects are discussed concerning antecedents and influence effects,the influence effects are shown in three aspects including the characteristics of individual,target,and environment.While the antecedent effects are respectively reflected in self-insight,personality,empowerment,and self-supported environment,content,and context of the goal itself.Finally,the author proposes several potential research interests from a broader perspective based on the current literature.展开更多
The over-the-air reprogramming has played an important role in Wireless Sensor Networks (WSNs), and has been widely researched. But the problems of low efficiency and high energy consumption have brought new challenge...The over-the-air reprogramming has played an important role in Wireless Sensor Networks (WSNs), and has been widely researched. But the problems of low efficiency and high energy consumption have brought new challenges to the research. This paper presents an optimal algorithm, it is targeted to address the problem of relatively low efficiency and high energy consumption in over-the-air reprogramming in WSNs. Simulation results demonstrate that the optimal algorithm can improve the efficiency of over-the-air reprogramming in WSNs, and make the energy consumption in network not only lower but more balanced.展开更多
The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers.Intracellular glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important r...The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers.Intracellular glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin resistance.Herein,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based chemotherapy.Specifically,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST inhibitor.Responding to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug release.Meanwhile,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug resistance.Moreover,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant melanoma.The in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth suppression.Overall,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers.展开更多
Symmetry breaking of metal cluster-based strongly correlated systems can give rise to collective phenomena.Here,the twodimensional Nb_(3) cluster compound Nb_(3)Cl_(8) is shown to suffer dramatic symmetry breaking and...Symmetry breaking of metal cluster-based strongly correlated systems can give rise to collective phenomena.Here,the twodimensional Nb_(3) cluster compound Nb_(3)Cl_(8) is shown to suffer dramatic symmetry breaking and electron disproportionation under compression.A structural phase transition from trigonal P–3m1 to monoclinic C2/m is observed near 8 GPa with the three-fold symmetry breaking.Electron disproportionation occurs on Nb_(3) clusters from delocalized Nb^(8/3+)Nb^(8/3+)Nb^(8/3+)to localized Nb^(3+)Nb^(3+)Nb^(2+),which results in a subtle bandgap discontinuity,as evidenced by electrical transport and UV-Vis absorption measurements.展开更多
Materials with zero-linear compressibility(ZLC)and zero-area compressibility(ZAC)have great promise for specific applications retaining constancy in specific directions or planes under external impaction.To date,no mo...Materials with zero-linear compressibility(ZLC)and zero-area compressibility(ZAC)have great promise for specific applications retaining constancy in specific directions or planes under external impaction.To date,no more than 10 ZLC/ZAC materials have been reported,most of which have very limited working pressure ranges(<10 GPa).Herein,we report the observation of ZLC and ZAC in Li2Ti(IO3)6 with a gear-spring type structure over an ultrawide pressure range(0–40 GPa).展开更多
基金Youth Program of National Natural Science Foundation of China(No.71702068).
文摘The average stress of people in China’s workplace is reaching the peak in recent two years.To improve employee’s positive psychological factors,Spiritual leadership has a good performance in this regard.Based on the mediating effect of goal self-concordance and self-efficacy,this paper further studies the impact of spiritual leadership on employee’s work engagement.Through the empirical study,the following conclusions are drawn:(1)Spiritual leadership significantly positively affects the employee’s work engagement.(2)Spiritual leadership has a significant positive effect on goal self-concordance and self-efficacy.(3)Goal self-concordance and self-efficacy have significant positive effects on employee’s work engagement.(4)Goal self-concordance and self-efficacy play a partial mediating role in the process of spiritual leadership’s impact on employees’work engagement.This study found the new mediator which partly revealed the mechanism between the effectiveness of Spiritual Leadership and employee’s work engagement.This study may serve as one of the researches for improving the effectiveness of leaders in organizations and promoting the motivation of employees in the workplace.
基金Youth Program of National Natural Science Foundation of China(No.71702068).
文摘Goal self-concordance reflects self-generated personal goals aligning with people’s interests and core values in one’s implicit personality as organic components,which is measured by the“perceived locus of causality”PLOC.Pursuing and achieving self-concordant goals both predict diversified outcomes in need-satisfaction,mental and physical well-being,positive attitude and behavior,etc.Based on expounding and sorting out the concept and measurement about goal self-concordance,the author analyzes the differences among a series of goal self-concor-dance theories.This paper focuses on the latest research trends and summarizesfive influencing aspects of goal self-concordance:mental health,cognition,emotion,personal will,and behavioral outcomes.The mediating effects are discussed concerning antecedents and influence effects,the influence effects are shown in three aspects including the characteristics of individual,target,and environment.While the antecedent effects are respectively reflected in self-insight,personality,empowerment,and self-supported environment,content,and context of the goal itself.Finally,the author proposes several potential research interests from a broader perspective based on the current literature.
文摘The over-the-air reprogramming has played an important role in Wireless Sensor Networks (WSNs), and has been widely researched. But the problems of low efficiency and high energy consumption have brought new challenges to the research. This paper presents an optimal algorithm, it is targeted to address the problem of relatively low efficiency and high energy consumption in over-the-air reprogramming in WSNs. Simulation results demonstrate that the optimal algorithm can improve the efficiency of over-the-air reprogramming in WSNs, and make the energy consumption in network not only lower but more balanced.
基金This work was financially supported by the National Natural Science Foundation of China(No.81803466)the Natural Science Foundation of Guangdong Province(No.2018A030310095,China)the Key Areas Research and Development Program of Guangdong Province(No.2019B020204002,China).
文摘The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers.Intracellular glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin resistance.Herein,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based chemotherapy.Specifically,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST inhibitor.Responding to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug release.Meanwhile,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug resistance.Moreover,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant melanoma.The in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth suppression.Overall,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers.
基金supported by the National Natural Science Foundation of China(Grant No.52073003)the Major Program of National Natural Science Foundation of China(Grant No.22090041)+1 种基金the National Key R&D Program of China(Grant No.2018YFA0305900)the Shanghai Sailing Program(Grant No.21YF1454400)。
文摘Symmetry breaking of metal cluster-based strongly correlated systems can give rise to collective phenomena.Here,the twodimensional Nb_(3) cluster compound Nb_(3)Cl_(8) is shown to suffer dramatic symmetry breaking and electron disproportionation under compression.A structural phase transition from trigonal P–3m1 to monoclinic C2/m is observed near 8 GPa with the three-fold symmetry breaking.Electron disproportionation occurs on Nb_(3) clusters from delocalized Nb^(8/3+)Nb^(8/3+)Nb^(8/3+)to localized Nb^(3+)Nb^(3+)Nb^(2+),which results in a subtle bandgap discontinuity,as evidenced by electrical transport and UV-Vis absorption measurements.
基金supported by the Major Program of the National Natural Science Foundation of China(no.22090041)the National Natural Science Foundation of China(no.52073003)the National Key R&D Program of China(no.2018YFA0305900).
文摘Materials with zero-linear compressibility(ZLC)and zero-area compressibility(ZAC)have great promise for specific applications retaining constancy in specific directions or planes under external impaction.To date,no more than 10 ZLC/ZAC materials have been reported,most of which have very limited working pressure ranges(<10 GPa).Herein,we report the observation of ZLC and ZAC in Li2Ti(IO3)6 with a gear-spring type structure over an ultrawide pressure range(0–40 GPa).