Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass...Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass loadings crucial for practical use.The root of these challenges lies in the mechanical instability of the material,which subsequently leads to the structural failure of the electrode.Here,we present a novel synthesis of a composite combining expanded graphite and silicon nanoparticles.This composite features a unique interlayer-bonded graphite structure,achieved through the application of a modified spark plasma sintering method.Notably,this innovative structure not only facilitates efficient ion and electron transport but also provides exceptional mechanical strength(Vickers hardness:up to658 MPa,Young's modulus:11.6 GPa).This strength effectively accommodates silicon expansion,resulting in an impressive areal capacity of 2.9 mA h cm^(-2)(736 mA h g^(-1)) and a steady cycle life(93% after 100cycles).Such outsta nding performance is paired with features appropriate for large-scale industrial production of silicon batteries,such as active mass loading of at least 3.9 mg cm^(-2),a high-tap density electrode material of 1.68 g cm^(-3)(secondary clusters:1.12 g cm^(-3)),and a production yield of up to 1 kg per day.展开更多
Integrins are heterodimeric cell surface receptors that bind to ligands on another cell,e.g.intercellular adhesion molecule 1(ICAM-1),or the extracellular matrix.Integrins play an important role in immune system,and t...Integrins are heterodimeric cell surface receptors that bind to ligands on another cell,e.g.intercellular adhesion molecule 1(ICAM-1),or the extracellular matrix.Integrins play an important role in immune system,and they participate in inflammation,thrombosis,and proliferation,migration and apoptosis of tumor cells.They mediate adhesion and transduce signals across the membrane usually under the influence of forces.A recent study has shown that integrins bind and activate transforming growth factorβisoform(TGF-β)which is involved in tumor suppression and growth,and blocking the binding of TGF-βto integrin can inhibit tumor growth.RGD(arginine-glycine-aspartate)small peptide,which competitively inhibits ligand binding to integrins,has been approved as an injectable drug.However,when the RGD is used to block cancer-related extracellular signaling pathways,it will also cause activation of integrins for a period,and stimulate the transduction of intracellular signals constantly.Therefore,it is necessary to explore for new drugs that can selectively control conformational state of integrins without activating or blocking all of them.In this study,we selected two small peptides,KQAGDV and RTDLDSLRT,that combined with integrins and do not contain an RGD sequence.The non-RGD polypeptide RTDLDSLRT has been reported to have a binding site with integrins and the binding affinity is on nanomolar scale.For the motif of the fibrinogen y chain C-terminal KQAGDV,it can adhere to the head of the integrins.The micropipette aspiration technique and electron microscopy techniques were used to study the adhesion and activation of integrins by peptides,respectively.Micropipette aspiration technique was used to investigate the adhesion frequency of peptide and integrin on Jurkat cell.The pressure system was used to supply a controllable negative pression to the microtube,and two micropipettes were used to absorb red blood cells and Jurkat cells,respectively.The red blood cells were coated with small peptides and can serve as a force sensor after being sucked when two cells were connected.The binding kinetics of integrin and peptides interactions was determined by fitting the curves constructed using adhesion probability between two cells as a function of time.The curves were fitted using a small system probabilistic kinetic model to estimate a pair of kinetic parameters,including the zero force reverse rate kr0,and the cellular binding affinity Acmrm1Ka0.The adhesion frequency yielded P(t)=75%and 57%for RGD and KQAG DV peptides,respectively.We obtained Acmrm1Ka0=1.40 and kr0=0.32 s-1,for RGD,and Acmrm1Ka0=0.85 and kr0=0.54 s-1 for KQAGDV.The RGD peptide has a higher adhesion frequency and lower dissociation rate than the KQAGDV peptide.Electron microscopy techniques was used to observe the activation of integrins by peptides.Jurkat cell expressing integrins was bound to a magnetic bead and bottom plate which were coated with different integrin-binding peptides.Then,we manipulated the beads in a controlled direction by changing the magnetic field nearby,and the forces were applied to the cell.The target cells were fixed and then observed by scanning electron microscope or transmission electron microscope.Jurkat cells contain abundant flexible microvilli of which there are many parallel bundles of actin filaments inside.By electron microscopy analysis,the cell connected with magnetic bead coated with RGD were found to be protruded and the size of microvilli increased up to#-fold of the length of the KQAGDV sample.The microvilli exhibited a curved agglomerate structure under a force-free condition.Moreover,a higher proportion of cells were activated in the presence of RGD than KQAGDV.In conclusion,the binding affinity of KQAGDV to integrin is weaker than RGD,and KQAGDV can bind with integrins effectively with a lower activated proportion.Our results indicate the peptides may selectively bind to integrins without activating them.展开更多
Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic force...Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2−and Zn2+which leads to poor cyclic stability.Herein,Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs.Improved cyclic stability and fast diffusion of Zn2+is observed.Also,the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+.As a result,the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca.100%retention.The battery also demonstrates good cyclic performance of ca.80.3%over 2000 cycles at 1 A g−1.The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution.This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability.展开更多
In order to develop functional energy storage device,it is necessary to improve the energy and power density.As a potential candidate that can synergistically harmonize energy and power density,lithium ion capacitor(L...In order to develop functional energy storage device,it is necessary to improve the energy and power density.As a potential candidate that can synergistically harmonize energy and power density,lithium ion capacitor(LIC)has shown exciting promises in recent years.However,in the recent years,alternative metal has been explored to replace lithium in such metal-ion capacitor system.Hence,in this work we present zinc ion capacitor(ZIC)in which zinc acts as negative electrode and Metal Organic framework(MOF)derived carbon as positive electrode.The assembled ZIC was able to demonstrate exceptional power density of 85.5 kW kg^-1 and a maximal energy density of 36.4W h kg^-1,together with 99%capacitance retention after cycling for 20000 cycles.展开更多
Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and mo...Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their potential.Here we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)printing.The mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional fillers.By taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic structures.In particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic field.This study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices.展开更多
Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline materials.Their tunable porosity,chemical composition,size and shape,and e...Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline materials.Their tunable porosity,chemical composition,size and shape,and easy surface functionalization make this large family more and more popular for drug delivery.There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications.This article presents an overall review and perspectives of MOFs-based drug delivery systems(DDSs),starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands.Then,the synthesis and characterization of MOFs for DDSs are developed,followed by the drug loading strategies,applications,biopharmaceutics and quality control.Importantly,a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics,diseases therapy and advanced DDSs.In particular,the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed.Finally,challenges in MOFs development for DDSs are discussed,such as biostability,biosafety,biopharmaceutics and nomenclature.展开更多
High entropy alloys(HEAs) have presented potential applications in nuclear power plants owing to their novel atomic structure based high irradiation resistance. However, understanding of He-ion irradiation of HEAs is ...High entropy alloys(HEAs) have presented potential applications in nuclear power plants owing to their novel atomic structure based high irradiation resistance. However, understanding of He-ion irradiation of HEAs is still lacking. In this work, we reveal He-ion irradiation resistance of HEA CrMnFeCoNi by comparison study with a pure Ni and a 304 stainless steel(304SS). It is found that the damage structure in the three materials can be characterized with He bubbles and stacking faults/stacking fault tetrahedrons((SFs/SFTs), which show a similar depth distribution after He-ion irradiation at both RT and 450℃.Although the He bubbles have a similar size about 2nm after irradiation at RT, the He bubble sizes of the HEA, 304SS, and Ni increase to 4.0±0.9,5.3±1.0 and 6.7 ±1.0 nm after irradiation at 450℃, respectively. Moreover, the density of SFs/SFTs displays in an order of Ni < 304 SS < HEA at both RT and 450℃.The He-ion irradiation at RT causes significant hardness enhancement for the three materials, however,compared to RT, after irradiation at 450℃, the Ni presents softening, while the 304SS, especially the HEA,shows further hardening. Thus, the HEA CrMnFeCoNi possesses the smallest He bubble size, the densest SFs/SFTs, and the highest hardening, indicating the best structural stability, as well as the best He-ion irradiation resistance, which can be attributed to its low mobility of He atoms and point defects.展开更多
Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.Howe...Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.However,the role of the interfaces in plastic deformation have not been revealed deeply.In the present work,the orientation relationship(OR)of the interfaces has been clarified as the Kurdjumov-Sachs(KS)interfaces presenting〈111〉_(B2) 〈110〉_(FCC)and {110} _(B2){111}_(FCC) independent of their morphologies.There exist three kinds of interfaces in the EHEA,namely,The dominating interface and the secondary interface are both non-slip planes and atomistic-scale faceted,facilitating the nucleation and slip transmission of the dislocations.The formation mechanism of the preferred interfaces is revealed using the atomistic geometrical analysis according to the criteria of the low interfacial energy based on the coincidence-site lattice(CSL)theory.In particular,the ductility of the dual-phase alloy originates from the KS interface-induced slip continuity across interfaces,which provides a high slip-transfer geometric factor.Moreover,the strengthening effect can be attributed to the interface resistance for the dislocation transmission due to the mismatches of the moduli and lattice parameters at the interfaces.展开更多
Radiation-tolerant materials are widely desired in nuclear reactors. High-entropy alloys(HEAs) exhibiting superior mechanical performance and swelling tolerance are being considered as next-generation nuclear structur...Radiation-tolerant materials are widely desired in nuclear reactors. High-entropy alloys(HEAs) exhibiting superior mechanical performance and swelling tolerance are being considered as next-generation nuclear structural materials. However, an understanding of HEAs irradiation tolerance at an atomic scale is still lacking. In this study, the atomic scale irradiation response of AlCoCrFeNi_(2.1), composed of face-centered cubic(FCC) phase and B2 phase, has been systematically investigated at 298 and 723 K. The bubble volume ratio of the B2 phase is much larger than that of the FCC phase under the same irradiation conditions, and hence, the FCC phase has superior swelling tolerance than the B2 phase. Also, order-disorder transformation occurred in both L12and B2 phases. The different irradiation responses between the FCC and B2 phases, depend firstly on composition and secondly on crystal structure. The higher compositional complexity and complicated atomic-level lattice environment of the FCC phase contribute to better radiation performance than B2 phase. The results pave a way for exploring radiation-tolerant structural high-entropy alloys.展开更多
It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases.When the inhalable micron-sized crystals ofγ-cyclodextrin metal-organic framework(CD-M...It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases.When the inhalable micron-sized crystals ofγ-cyclodextrin metal-organic framework(CD-MOF)was utilized as dry powder inhalers(DPIs)carrier with high fine particle fraction(FPF),it was found in this research that the encapsulation of a glycoside compound,namely,scutellarin(SCU)in CD-MOF could significantly enhance its laryngeal deposition.Firstly,SCU loading into CD-MOF was optimized by incubation.Then,a series of characterizations were carried out to elucidate the mechanisms of drug loading.Finally,the laryngeal deposition rate of CD-MOF was 57.72±2.19%improved by SCU,about two times higher than that of CD-MOF,when it was determined by Next Generation Impactor(NGI)at 65 L/min.As a proof of concept,pharyngolaryngitis therapeutic agent dexamethasone(DEX)had improved laryngeal deposition after being co-encapsulated with SCU in CDMOF.The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF,which defined the enhanced laryngeal anchoring.In conclusion,the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.展开更多
The hydroxyapatite-loaded swine manure derived-biocarbon was successfully prepared by pyrolysis method for the adsorption of uranium(Ⅵ).The results of the adsorption experiments displayed that the adsorption behavior...The hydroxyapatite-loaded swine manure derived-biocarbon was successfully prepared by pyrolysis method for the adsorption of uranium(Ⅵ).The results of the adsorption experiments displayed that the adsorption behaviors for uranium(Ⅵ)of biocarbon did almost not depend on the interfering ions except Al^(3+),Ca^(2+)and CO_(3)^(2−),showing the high selectivity of the composites for uranium(Ⅵ).The maximum static and dynamic removal capacity of the hydroxyapatite-biocarbon composites to uranium(Ⅵ)were 834.8 and 782.8 mg/g(pH=3,m/V=0.1 g/L and T=298 K),far exceeding other reported biocarbon and hydroxyapatite materials,which indicated that the hydroxyapatite-biocarbon composites possessed an application potential in adsorption.After five cycles of adsorption-desorption processes,the removal efficiency of the hydroxyapatite-biocarbon composite for uranium(Ⅵ)was 93.2%(C_(i)=5 mg/L,pH=3,m/V=0.1 g/L and T=298 K),revealing that the composite had excellent stability and reusability.Moreover,the capture mechanisms of the hydroxyapatite-biocarbon composite for uranium(Ⅵ)included ion exchange and complexation,which was ascribed to the ample active adsorption sites(-OH and PO_(4)^(3−)).Therefore,the hydroxyapatite-loaded swine manure derived-biocarbon would be a potential material to effectually separate uranium(Ⅵ)from solution.展开更多
In this work, a quaternary Ni-Cu-Nb-Ta system has been designed to obtain composite microstructure with sphericalcrystalline Cu-rich particles embedded in amorphous Ni-rich matrix. The alloy samples were prepared by u...In this work, a quaternary Ni-Cu-Nb-Ta system has been designed to obtain composite microstructure with sphericalcrystalline Cu-rich particles embedded in amorphous Ni-rich matrix. The alloy samples were prepared by using single-roller melting-spinning method. The microstructure and thermal properties of the as-quenched alloy samples were char-acterized by X-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, anddifferential scanning calorimetry. It shows that the spherical crystalline Cu-rich particles are embedded in the amorphousNi-rich matrix. The average size of the Cu-rich particles is strongly dependent upon the Cu content. The effect of the alloycomposition on the behavior of liquid-liquid phase separation and microstructure evolution was discussed. The phaseformation in the Ni-based metallic glass matrix composite was analyzed.展开更多
An intriguing Brønsted acid-catalyzed 1,6-hydrophosphination of in situ generated propargylic para-quinone methides(p-QMs)and aza-para-quinone methides(aza-p-QMs)with H-phosphorus oxides via dehydration/1,6-addit...An intriguing Brønsted acid-catalyzed 1,6-hydrophosphination of in situ generated propargylic para-quinone methides(p-QMs)and aza-para-quinone methides(aza-p-QMs)with H-phosphorus oxides via dehydration/1,6-addition under ultrasonic irradiation is described.This methodology provides a rapid and green approach for the construction of diarylmethyl phosphorus oxides bearing phosphorus-substituted quaternary carbon centers in high yields(up to 98%yield)within merely 5min.This environmentally benign protocol represents a unique example of 1,6-conjugate additions of propargylic p-QMs and aza-p-QMs for site-selective C-P bond formation in an operationally simple and atom-economical manner.The use of readily available Brønsted acid catalyst,operationally simplicity,high yields,and high atom economy make this protocol very facile,practical,easily scaled-up and environmentally friendly.展开更多
基金supported by the National Research Foundation, Prime Minister’s Office, Singapore, under its Competitive Research Programme (CRP award number NRF-CRP22-2019-008)Medium-Sized Centre Programme (CA2DM)+1 种基金the Ministry of Education of Singapore, under its Research Centre of Excellence award to the Institute for Functional Intelligent Materials (I-FIM, Project No. EDUNC-33-18-279-V12)by the EDB Singapore, under its Space Technology Development Programme (S2219013-STDP)。
文摘Despite advancements in silicon-based anodes for high-capacity lithium-ion batteries,their widespread commercial adoption is still hindered by significant volume expansion during cycling,especially at high active mass loadings crucial for practical use.The root of these challenges lies in the mechanical instability of the material,which subsequently leads to the structural failure of the electrode.Here,we present a novel synthesis of a composite combining expanded graphite and silicon nanoparticles.This composite features a unique interlayer-bonded graphite structure,achieved through the application of a modified spark plasma sintering method.Notably,this innovative structure not only facilitates efficient ion and electron transport but also provides exceptional mechanical strength(Vickers hardness:up to658 MPa,Young's modulus:11.6 GPa).This strength effectively accommodates silicon expansion,resulting in an impressive areal capacity of 2.9 mA h cm^(-2)(736 mA h g^(-1)) and a steady cycle life(93% after 100cycles).Such outsta nding performance is paired with features appropriate for large-scale industrial production of silicon batteries,such as active mass loading of at least 3.9 mg cm^(-2),a high-tap density electrode material of 1.68 g cm^(-3)(secondary clusters:1.12 g cm^(-3)),and a production yield of up to 1 kg per day.
基金supported by the National Science Foundation of China ( 11772133, 11372116)
文摘Integrins are heterodimeric cell surface receptors that bind to ligands on another cell,e.g.intercellular adhesion molecule 1(ICAM-1),or the extracellular matrix.Integrins play an important role in immune system,and they participate in inflammation,thrombosis,and proliferation,migration and apoptosis of tumor cells.They mediate adhesion and transduce signals across the membrane usually under the influence of forces.A recent study has shown that integrins bind and activate transforming growth factorβisoform(TGF-β)which is involved in tumor suppression and growth,and blocking the binding of TGF-βto integrin can inhibit tumor growth.RGD(arginine-glycine-aspartate)small peptide,which competitively inhibits ligand binding to integrins,has been approved as an injectable drug.However,when the RGD is used to block cancer-related extracellular signaling pathways,it will also cause activation of integrins for a period,and stimulate the transduction of intracellular signals constantly.Therefore,it is necessary to explore for new drugs that can selectively control conformational state of integrins without activating or blocking all of them.In this study,we selected two small peptides,KQAGDV and RTDLDSLRT,that combined with integrins and do not contain an RGD sequence.The non-RGD polypeptide RTDLDSLRT has been reported to have a binding site with integrins and the binding affinity is on nanomolar scale.For the motif of the fibrinogen y chain C-terminal KQAGDV,it can adhere to the head of the integrins.The micropipette aspiration technique and electron microscopy techniques were used to study the adhesion and activation of integrins by peptides,respectively.Micropipette aspiration technique was used to investigate the adhesion frequency of peptide and integrin on Jurkat cell.The pressure system was used to supply a controllable negative pression to the microtube,and two micropipettes were used to absorb red blood cells and Jurkat cells,respectively.The red blood cells were coated with small peptides and can serve as a force sensor after being sucked when two cells were connected.The binding kinetics of integrin and peptides interactions was determined by fitting the curves constructed using adhesion probability between two cells as a function of time.The curves were fitted using a small system probabilistic kinetic model to estimate a pair of kinetic parameters,including the zero force reverse rate kr0,and the cellular binding affinity Acmrm1Ka0.The adhesion frequency yielded P(t)=75%and 57%for RGD and KQAG DV peptides,respectively.We obtained Acmrm1Ka0=1.40 and kr0=0.32 s-1,for RGD,and Acmrm1Ka0=0.85 and kr0=0.54 s-1 for KQAGDV.The RGD peptide has a higher adhesion frequency and lower dissociation rate than the KQAGDV peptide.Electron microscopy techniques was used to observe the activation of integrins by peptides.Jurkat cell expressing integrins was bound to a magnetic bead and bottom plate which were coated with different integrin-binding peptides.Then,we manipulated the beads in a controlled direction by changing the magnetic field nearby,and the forces were applied to the cell.The target cells were fixed and then observed by scanning electron microscope or transmission electron microscope.Jurkat cells contain abundant flexible microvilli of which there are many parallel bundles of actin filaments inside.By electron microscopy analysis,the cell connected with magnetic bead coated with RGD were found to be protruded and the size of microvilli increased up to#-fold of the length of the KQAGDV sample.The microvilli exhibited a curved agglomerate structure under a force-free condition.Moreover,a higher proportion of cells were activated in the presence of RGD than KQAGDV.In conclusion,the binding affinity of KQAGDV to integrin is weaker than RGD,and KQAGDV can bind with integrins effectively with a lower activated proportion.Our results indicate the peptides may selectively bind to integrins without activating them.
基金the financial supports from the National Natural Science Foundation of China(Nos.72088101,51739004,72004060,21776066)the Natural Science Foundation of Hunan Province,China(No.2021JJ40157)the Scientific Research Project of Hunan Education Department,China(No.20C0545)。
文摘Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2−and Zn2+which leads to poor cyclic stability.Herein,Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs.Improved cyclic stability and fast diffusion of Zn2+is observed.Also,the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+.As a result,the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca.100%retention.The battery also demonstrates good cyclic performance of ca.80.3%over 2000 cycles at 1 A g−1.The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution.This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability.
文摘In order to develop functional energy storage device,it is necessary to improve the energy and power density.As a potential candidate that can synergistically harmonize energy and power density,lithium ion capacitor(LIC)has shown exciting promises in recent years.However,in the recent years,alternative metal has been explored to replace lithium in such metal-ion capacitor system.Hence,in this work we present zinc ion capacitor(ZIC)in which zinc acts as negative electrode and Metal Organic framework(MOF)derived carbon as positive electrode.The assembled ZIC was able to demonstrate exceptional power density of 85.5 kW kg^-1 and a maximal energy density of 36.4W h kg^-1,together with 99%capacitance retention after cycling for 20000 cycles.
基金Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200375National Natural Science Foundation of China,Grant/Award Number:22109021+2 种基金Fundamental Research Funds for the Central Universities,Grant/Award Number:2242021R10023Ministry of Education,Singapore,Grant/Award Number:R284000193114Jiangsu Shuangchuang Talent Program,Grant/Award Number:JSSCBS20210100。
文摘Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their potential.Here we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)printing.The mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional fillers.By taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic structures.In particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic field.This study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices.
基金financially supported by the National Key R&D Program of China(No.2020YFE0201700)National Nature Science Foundation of China(No.81773645)a public grant overseen by the French National Research Agency(ANR),France as part of the“Investissements d’Avenir”program(Labex NanoSaclay:ANR-10-LABX-0035,France)
文摘Metal-organic frameworks(MOFs),comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous,crystalline materials.Their tunable porosity,chemical composition,size and shape,and easy surface functionalization make this large family more and more popular for drug delivery.There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications.This article presents an overall review and perspectives of MOFs-based drug delivery systems(DDSs),starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands.Then,the synthesis and characterization of MOFs for DDSs are developed,followed by the drug loading strategies,applications,biopharmaceutics and quality control.Importantly,a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics,diseases therapy and advanced DDSs.In particular,the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed.Finally,challenges in MOFs development for DDSs are discussed,such as biostability,biosafety,biopharmaceutics and nomenclature.
基金supported financially by the "Hundred Talents Project" of Chinese Academy of Sciencesthe "Thousand Youth Talents Plan" of China+1 种基金the National Natural Science Foundation of China (Nos. 51401208 and 51771201)the Shenyang National Laboratory for Materials Science (No. 2017RP17)
文摘High entropy alloys(HEAs) have presented potential applications in nuclear power plants owing to their novel atomic structure based high irradiation resistance. However, understanding of He-ion irradiation of HEAs is still lacking. In this work, we reveal He-ion irradiation resistance of HEA CrMnFeCoNi by comparison study with a pure Ni and a 304 stainless steel(304SS). It is found that the damage structure in the three materials can be characterized with He bubbles and stacking faults/stacking fault tetrahedrons((SFs/SFTs), which show a similar depth distribution after He-ion irradiation at both RT and 450℃.Although the He bubbles have a similar size about 2nm after irradiation at RT, the He bubble sizes of the HEA, 304SS, and Ni increase to 4.0±0.9,5.3±1.0 and 6.7 ±1.0 nm after irradiation at 450℃, respectively. Moreover, the density of SFs/SFTs displays in an order of Ni < 304 SS < HEA at both RT and 450℃.The He-ion irradiation at RT causes significant hardness enhancement for the three materials, however,compared to RT, after irradiation at 450℃, the Ni presents softening, while the 304SS, especially the HEA,shows further hardening. Thus, the HEA CrMnFeCoNi possesses the smallest He bubble size, the densest SFs/SFTs, and the highest hardening, indicating the best structural stability, as well as the best He-ion irradiation resistance, which can be attributed to its low mobility of He atoms and point defects.
基金supported financially by the National Natural Science Foundation of China(No.51771201 and No.51822402)the Key Project of Natural Science Foundation of Liaoning Province+4 种基金China(No.20180510059)the Shenyang National Laboratory for Materials Science(No.2017RP17)the State Key Laboratory of Solidification Processing in Northwestern Polytechnical University(No.SKLSP201902)support of the U.S.Army Research Office Project(W911NF-13-1-0438 and W911NF-19-2-0049)with the program managers,Drs.M.P.Bakas,S.N.Mathaudhu,D.M.Steppsupport from the National Science Foundation(DMR-1611180 and DMR-1809640)with the program directors,Drs.J.Yang,G.Shiflet,D.Farkas。
文摘Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.However,the role of the interfaces in plastic deformation have not been revealed deeply.In the present work,the orientation relationship(OR)of the interfaces has been clarified as the Kurdjumov-Sachs(KS)interfaces presenting〈111〉_(B2) 〈110〉_(FCC)and {110} _(B2){111}_(FCC) independent of their morphologies.There exist three kinds of interfaces in the EHEA,namely,The dominating interface and the secondary interface are both non-slip planes and atomistic-scale faceted,facilitating the nucleation and slip transmission of the dislocations.The formation mechanism of the preferred interfaces is revealed using the atomistic geometrical analysis according to the criteria of the low interfacial energy based on the coincidence-site lattice(CSL)theory.In particular,the ductility of the dual-phase alloy originates from the KS interface-induced slip continuity across interfaces,which provides a high slip-transfer geometric factor.Moreover,the strengthening effect can be attributed to the interface resistance for the dislocation transmission due to the mismatches of the moduli and lattice parameters at the interfaces.
基金supported by financial support from the National Natural Science Foundation of China(Nos.51771201 and 52071124)the Key Project of Natural Science Foundation of Tianjin(No.20JCZDJC00440)+1 种基金the National Key Research and Development Program(No.2018YFB0703402)the Open Research Fund from the State Key Laboratory of Rolling and Automation,Northeastern University(No.2020RALKFKT002)。
文摘Radiation-tolerant materials are widely desired in nuclear reactors. High-entropy alloys(HEAs) exhibiting superior mechanical performance and swelling tolerance are being considered as next-generation nuclear structural materials. However, an understanding of HEAs irradiation tolerance at an atomic scale is still lacking. In this study, the atomic scale irradiation response of AlCoCrFeNi_(2.1), composed of face-centered cubic(FCC) phase and B2 phase, has been systematically investigated at 298 and 723 K. The bubble volume ratio of the B2 phase is much larger than that of the FCC phase under the same irradiation conditions, and hence, the FCC phase has superior swelling tolerance than the B2 phase. Also, order-disorder transformation occurred in both L12and B2 phases. The different irradiation responses between the FCC and B2 phases, depend firstly on composition and secondly on crystal structure. The higher compositional complexity and complicated atomic-level lattice environment of the FCC phase contribute to better radiation performance than B2 phase. The results pave a way for exploring radiation-tolerant structural high-entropy alloys.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA12050307,China)the ANR AntiTBnano project(ANR-14-CE08-0017,France)the National Research Council of Science and Technology Major Projects for“Major New Drugs Innovation and Development”(2018ZX09721002e009,China)
文摘It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases.When the inhalable micron-sized crystals ofγ-cyclodextrin metal-organic framework(CD-MOF)was utilized as dry powder inhalers(DPIs)carrier with high fine particle fraction(FPF),it was found in this research that the encapsulation of a glycoside compound,namely,scutellarin(SCU)in CD-MOF could significantly enhance its laryngeal deposition.Firstly,SCU loading into CD-MOF was optimized by incubation.Then,a series of characterizations were carried out to elucidate the mechanisms of drug loading.Finally,the laryngeal deposition rate of CD-MOF was 57.72±2.19%improved by SCU,about two times higher than that of CD-MOF,when it was determined by Next Generation Impactor(NGI)at 65 L/min.As a proof of concept,pharyngolaryngitis therapeutic agent dexamethasone(DEX)had improved laryngeal deposition after being co-encapsulated with SCU in CDMOF.The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF,which defined the enhanced laryngeal anchoring.In conclusion,the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.
基金the National Natural Science Foundation of China(No.21902130 and 21976147)Sichuan Science and Technology Program(No.2020JDJQ0009,2020ZDZX0012,2020JDRC0099,2020YFG0467 and 2020YFS0345)+3 种基金the Career Development Funding of CAEP(2402001)the Presidential Funding of CAEP(YZJJLX2019007)Research Fund of SWUST for Ph.D.(No.19zx7129,18zx7149 and 17zx7135)Sichuan’s Training Program of Innovation and Entrepreneurship for Undergraduate(No.S202110619086 and S202110619061).
文摘The hydroxyapatite-loaded swine manure derived-biocarbon was successfully prepared by pyrolysis method for the adsorption of uranium(Ⅵ).The results of the adsorption experiments displayed that the adsorption behaviors for uranium(Ⅵ)of biocarbon did almost not depend on the interfering ions except Al^(3+),Ca^(2+)and CO_(3)^(2−),showing the high selectivity of the composites for uranium(Ⅵ).The maximum static and dynamic removal capacity of the hydroxyapatite-biocarbon composites to uranium(Ⅵ)were 834.8 and 782.8 mg/g(pH=3,m/V=0.1 g/L and T=298 K),far exceeding other reported biocarbon and hydroxyapatite materials,which indicated that the hydroxyapatite-biocarbon composites possessed an application potential in adsorption.After five cycles of adsorption-desorption processes,the removal efficiency of the hydroxyapatite-biocarbon composite for uranium(Ⅵ)was 93.2%(C_(i)=5 mg/L,pH=3,m/V=0.1 g/L and T=298 K),revealing that the composite had excellent stability and reusability.Moreover,the capture mechanisms of the hydroxyapatite-biocarbon composite for uranium(Ⅵ)included ion exchange and complexation,which was ascribed to the ample active adsorption sites(-OH and PO_(4)^(3−)).Therefore,the hydroxyapatite-loaded swine manure derived-biocarbon would be a potential material to effectually separate uranium(Ⅵ)from solution.
基金supported by the National Natural Science Foundation of China(Grant Nos.51774264,51574216 and 51374194)the Natural Science Foundation of Liaoning Province of China(Grant No.2015020172)
文摘In this work, a quaternary Ni-Cu-Nb-Ta system has been designed to obtain composite microstructure with sphericalcrystalline Cu-rich particles embedded in amorphous Ni-rich matrix. The alloy samples were prepared by using single-roller melting-spinning method. The microstructure and thermal properties of the as-quenched alloy samples were char-acterized by X-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, anddifferential scanning calorimetry. It shows that the spherical crystalline Cu-rich particles are embedded in the amorphousNi-rich matrix. The average size of the Cu-rich particles is strongly dependent upon the Cu content. The effect of the alloycomposition on the behavior of liquid-liquid phase separation and microstructure evolution was discussed. The phaseformation in the Ni-based metallic glass matrix composite was analyzed.
基金We are grateful for financial support from the National Natural Science Foundation of China(No.21762005)Natural Science Foundation of Guangxi Province(No.2021GXNSFDA075005).
文摘An intriguing Brønsted acid-catalyzed 1,6-hydrophosphination of in situ generated propargylic para-quinone methides(p-QMs)and aza-para-quinone methides(aza-p-QMs)with H-phosphorus oxides via dehydration/1,6-addition under ultrasonic irradiation is described.This methodology provides a rapid and green approach for the construction of diarylmethyl phosphorus oxides bearing phosphorus-substituted quaternary carbon centers in high yields(up to 98%yield)within merely 5min.This environmentally benign protocol represents a unique example of 1,6-conjugate additions of propargylic p-QMs and aza-p-QMs for site-selective C-P bond formation in an operationally simple and atom-economical manner.The use of readily available Brønsted acid catalyst,operationally simplicity,high yields,and high atom economy make this protocol very facile,practical,easily scaled-up and environmentally friendly.