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Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma
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作者 tingming liang Lin Jia +5 位作者 Rui Duan Lulu Shen Dekang Ren Yujie Ren Yuyang Dou Li Guo 《Genes & Diseases》 SCIE CSCD 2023年第1期69-71,共3页
Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective non... Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA). 展开更多
关键词 diagnosis mortality ALONE
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