白细胞介素-6在肿瘤免疫检查点抑制剂治疗中的作用研究进展

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)作为一种免疫疗法,在多种癌症的治疗中发挥着重要作用,同时,其可诱导多种免疫相关不良事件(immune-related adverse events,irAEs)的发生。白细胞介素-6(interleukin-6,IL-6)是一种重要的炎症因子,已被证明可通过多种机制促进癌症进展及影响ICIs的临床应用。本文就细胞因子IL-6如何调节免疫检查点的表达以及对免疫阻断疗法和irAEs的影响进行探讨,总结靶向IL-6信号转导对ICIs功效及irAEs治疗的作用。

GHz photon-number resolving detection with high detection efficiency and low noise by ultra-narrowband interference circuits

We demonstrate the photon-number resolution(PNR)capability of a 1.25 GHz gated InGaAs single-photon avalanche photodiode(APD)that is equipped with a simple,low-distortion ultra-narrowband interference circuit for the rejection of its background capacitive response.Through discriminating the avalanche current amplitude,we are able to resolve up to four detected photons in a single detection gate with a detection efficiency as high as 45%.The PNR capability is limited by the avalanche current saturation,and can be increased to five photons at a lower detection efficiency of 34%.The PNR capability,combined with high efficiency and low noise,will find applications in quantum information processing technique based on photonic qubits.

Synergistic“Anchor‑Capture”Enabled by Amino and Carboxyl for Constructing Robust Interface of Zn Anode

While the rechargeable aqueous zinc-ion batteries(AZIBs)have been recognized as one of the most viable batteries for scale-up application,the instability on Zn anode–electrolyte interface bottleneck the further development dramatically.Herein,we utilize the amino acid glycine(Gly)as an electrolyte additive to stabilize the Zn anode–electrolyte interface.The unique interfacial chemistry is facilitated by the synergistic“anchor-capture”effect of polar groups in Gly molecule,manifested by simultaneously coupling the amino to anchor on the surface of Zn anode and the carboxyl to capture Zn^(2+)in the local region.As such,this robust anode–electrolyte interface inhibits the disordered migration of Zn^(2+),and effectively suppresses both side reactions and dendrite growth.The reversibility of Zn anode achieves a significant improvement with an average Coulombic efficiency of 99.22%at 1 mA cm^(−2)and 0.5 mAh cm^(−2)over 500 cycles.Even at a high Zn utilization rate(depth of discharge,DODZn)of 68%,a steady cycle life up to 200 h is obtained for ultrathin Zn foils(20μm).The superior rate capability and long-term cycle stability of Zn–MnO_(2)full cells further prove the effectiveness of Gly in stabilizing Zn anode.This work sheds light on additive designing from the specific roles of polar groups for AZIBs.

The chromosome-level quality genome provides insights into the evolution of the biosynthesis genes for aroma compounds of Osmanthus fragrans

Sweet osmanthus(Osmanthus fragrans)is a very popular ornamental tree species throughout Southeast Asia and USA particularly for its extremely fragrant aroma.We constructed a chromosome-level reference genome of O.fragrans to assist in studies of the evolution,genetic diversity,and molecular mechanism of aroma development.A total of over 118 Gb of polished reads was produced from HiSeq(45.1 Gb)and PacBio Sequel(73.35 Gb),giving 100×depth coverage for long reads.The combination of Illumina-short reads,PacBio-long reads,and Hi-C data produced the final chromosome quality genome of O.fragrans with a genome size of 727 Mb and a heterozygosity of 1.45%.The genome was annotated using de novo and homology comparison and further refined with transcriptome data.The genome of O.fragrans was predicted to have 45,542 genes,of which 95.68%were functionally annotated.Genome annotation found 49.35%as the repetitive sequences,with long terminal repeats(LTR)being the richest(28.94%).Genome evolution analysis indicated the evidence of whole-genome duplication 15 million years ago,which contributed to the current content of 45,242 genes.Metabolic analysis revealed that linalool,a monoterpene is the main aroma compound.Based on the genome and transcriptome,we further demonstrated the direct connection between terpene synthases(TPSs)and the rich aromatic molecules in O.fragrans.We identified three new flower-specific TPS genes,of which the expression coincided with the production of linalool.Our results suggest that the high number of TPS genes and the flower tissue-and stage-specific TPS genes expressions might drive the strong unique aroma production of O.fragrans.

Biopolymer passivation for high-performance perovskite solar cells by blade coating

Thin films of perovskite deposited from solution inevitably introduce large number of defects,which serve as recombination centers and are detrimental for solar cell performance.Although many small molecules and polymers have been delicately designed to migrate defects of perovskite films,exploiting credible passivation agents based on natural materials would offer an alternative approach.Here,an ecofriendly and cost-effective biomaterial,ploy-L-lysine(PLL),is identified to effectively passivate the defects of perovskite films prepared by blade-coating.It is found that incorporation of a small amount(2.5 mg mL^(-1))of PLL significantly boosts the performance of printed devices,yielding a high efficiency of 19.45% with an increase in open-circuit voltage by up to 100 mV.Density functional theory calculations combined with X-ray photoelectron spectroscopy reveal that the functional groups(-NH2,-COOH)of PLL effectively migrate the Pb-I antisite defects via Pb-N coordination and suppress the formation of metallic Pb in the blade-coated perovskite film.This work suggests a viable avenue to exploit passivation agents from natural materials for preparation of high-quality perovskite layers for optoelectronic applications.

Asymmetric coherent rainbows induced by liquid convection

Coherent rainbows can be formed by focusing white-light laser into liquids.They are bilaterally symmetric interference rings with various shapes.Such interference rings arise from the temperature distribution of the liquid induced by laser heating,i.e.,thermal lens effect,which changes the refractive index locally and thus the optical path difference.The up-down asymmetry of the interference rings is caused by convection in the liquid.With the increase of the viscosity,the interference rings change their shape from oval to circular shape.After a shutter is opened and the laser shines into the liquid,the interference rings are circular at the beginning.As time goes on,they gradually turn into an oval shape.Let the liquid go a free-fall at the beginning,the interference rings remain circular.All the three experiments have confirmed that the asymmetric interference rings are due to convection in the liquid associated with thermal lens effect.We also numerically simulate the two-dimensional heat conduction with and without convection,whose results agree well with our experimental observations.

Experimental Test of Contextuality Based on State Discrimination with a Single Qubit

Exploring quantum phenomena beyond predictions of any classical model has fundamental importance to understand the boundary of classical and quantum descriptions of nature.As a typical property that a quantum system behaves distinctively from a classical counterpart,contextuality has been studied extensively and verified experimentally in systems composed of at least three levels(qutrit).Here we extend the scope of experimental test of contextuality to a minimal quantum system of only two states(qubit)by implementing the minimum error state discrimination on a single171Yb+ion.We observe a substantial violation of a no-go inequality derived by assuming non-contextuality,and firmly conclude that the measured results of state discrimination cannot be reconciled with any non-contextual description.We also quantify the contextual advantage of state discrimination and the tolerance against quantum noises.

Author Correction:The chromosome-level quality genome provides insights into the evolution of the biosynthesis genes for aroma compounds of Osmanthus fragrans

Since the publication of this article,the authors have noticed that the NCBI accession number is missing from article.

Effective Teaching Methods in Korean Language Classes

The globalization of the economy has led to an increase in economic,political,and cultural activities in Korea.Across the sea from Korea,trade and cultural exchanges are frequent,thus increasing the demand for Korean language talents.Many colleges and universities have started to offer Korean language courses to enhance the training of Korean language talents.Most of the students in colleges and universities are starting from scratch in order to develop Korean language talents with a four-year time frame with More capable Korean language talents need to ensure the effectiveness of classroom teaching.This paper analyzes the characteristics of Korean language classroom teaching and its effectiveness.

The super-pangenome of Populus unveils genomic facets for its adaptation and diversification in widespread forest trees

Understanding the underlying mechanisms and links between genome evolution and adaptive innovations stands as a key goal in evolutionary studies.Poplars,among the world’s most widely distributed and cultivated trees,exhibit extensive phenotypic diversity and environmental adaptability.In this study,we present a genus-level super-pangenome comprising 19 Populus genomes,revealing the likely pivotal role of private genes in facilitating local environmental and climate adaptation.Through the integration of pangenomes with transcriptomes,methylomes,and chromatin accessibility mapping,we unveil that the evolutionary trajectories of pangenes and duplicated genes are closely linked to local genomic landscapes of regulatory and epigenetic architectures,notably CG methylation in gene-body regions.Further comparative genomic analyses have enabled the identification of 142202 structural variants across species that intersect with a significant number of genes and contribute substantially to both phenotypic and adaptive divergence.We have experimentally validated a∼180-bp presence/absence variant affecting the expression of the CUC2 gene,crucial for leaf serration formation.Finally,we developed a user-friendly web-based tool encompassing the multi-omics resources associated with the Populus super-pangenome(http://www.populus-superpangenome.com).Together,the present pioneering super-pangenome resource in forest trees not only aids in the advancement of breeding efforts of this globally important tree genus but also offers valuable insights into potential avenues for comprehending tree biology.

Lateral damage mechanism of the double-track tunnel in the mountainous layered soft rock and NPR anchor cable control

Due to complex geological formations,lateral damage often occurs during excavation in mountainous layered soft rock double-track tunnels.This paper discusses the stresses and the damage characteristics of the surrounding rock under overload in a mountainous layered soft rock double-track tunnel through indoor model experiments to provide a basis for the effective control of lateral damage.The experiments show that the conventional support method cannot effectively control the lateral damage due to interlayer sliding.Therefore,the negative Poisson’s ratio(NPR)anchor/cable control method is proposed.And the scientificity and feasibility of the NPR anchor/cable control technology are proved by the field application and monitoring data of the Minxian Tunnel and Changning Tunnel.It is further demonstrated that high preload is the most effective way to control the lateral damage in layered soft rock tunnels.

In vivo dissolution of poorly water-soluble drugs:Proof of concept based on fluorescence bioimaging

In vitro-in vivo correlation(IVIVC)of solid dosage forms should be established basically between in vitro and in vivo dissolution of active pharmaceutical ingredients.Nevertheless,in vivo dissolution profles have never been accurately portrayed.The current practice of IVIVC has to resort to in vivo absorption fractions(Fa).In this proof-of-concept study,in vivo dissolution of a model poorly watersoluble drug fenofbrate(FNB)was investigated by fuorescence bioimaging.FNB crystals were frst labeled by near-infrared fuorophores with aggregation-caused quenching properties.The dyes illuminated FNB crystals but quenched immediately and absolutely once been released into aqueous media,enabling accurate monitoring of residual drug crystals.The linearity established between fuorescence and crystal concentration justifed reliable quantifcation of FNB crystals.In vitro dissolution was frst measured following pharmacopoeia monograph protocols with well-documented IVIVC.The synchronicity between fuorescence and in vitro dissolution of FNB supported using fuorescence as a measure for determination of dissolution.In vitro dissolution correlated well with in vivo dissolution,acquired by either live or ex vivo imaging.The newly established IVIVC was further validated by correlating both in vitro and in vivo dissolution with Faobtained from pharmacokinetic data.

Not vegetation itself but mis-revegetation reduces water resources

Increasing greening of planet Earth to slow down the rise of atmospheric CO_(2) concentrations is certainly desirable;however,its consequences on water resources are less affirmative and thus are a matter of wide concern.China,as the largest and most successful country of the world in terms of artificial revegetation,is naturally the focus of the concerns and warnings.Based on previous studies,we analyzed the mechanism for the effects of climate and watershed characteristics on water resources,explained various hydrological results and phenomena,and considered the ways in which water consumption by artificial revegetation projects can be reduced.Moreover,some guidelines are suggested for artificial revegetation at watershed scale with consideration of water resource sustainability.The findings of this study highlight the need for more top-down approaches when studying the mechanism of"forest and water".

A digital lightning prototype system: DLPS/HUST

Digital lightning is an important thematic branch of the digital earth.Lightning data are complex,momentary,discrete,dynamic and spatio-temporal in nature.Hence,making great progress in their management,analysis and service is challenging.Many studies have been directed towards this field all over the world.Some different relevant systems are currently available.However,most of them focus on a single or a few aspects of lightning applications,rather than taking an overall account of lightning detection,management,analysis and service from the strategic perspective of the digital earth.Lightning disaster also demands a better developed spatial information technology in this field than at present.The idea of the digital earth offers a reasonable scheme to address these issues.Based on reviews of the concept,development and progress of the digital earth,an integrated technical framework of a digital lightning prototype system(DLPS)is proposed,including its data,functions and implementation of subsystems,which aims at the facilitation,management,accessing,visualisation,application,release and sharing of lightning data.Some key technologies are also carefully discussed to facilitate the construction of the DLPS.This framework could provide a helpful guide to future lightning research and hazard mitigation,as well as enrich connotation on the digital earth.So far,there are still many difficulties in multilevel grid construction that need to be solved.