Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis

Objective The aim of the study was to systematically evaluate the correlation between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia.Methods Computer databases including PubMed,EMBASE,and Web of Science were searched for case-control studies on the association between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia.The retrieval period was from the establishment of the database to November 2020.Two researchers independently screened the literature,extracted the data,evaluated the risk of bias in the included studies,and used Stata 14.0 software for meta-analysis.Results A total of 48 case-control studies were included,with 10520 and 44049 cases in the case and control groups,respectively.The meta-analysis results showed that rs4132061 and rs11978267 of IKZF1 were significantly correlated with the risk of acute lymphoblastic leukemia(ALL).Conclusion Current evidence indicates that rs4132061 and rs11978267 of IKZF1 are significantly associated with the risk of B-cell ALL.

Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

Androgenic alopecia(AGA)is a highly prevalent form of non-scarring alopecia but lacks effective treatments.Stem cell exosomes have similar repair effects to stem cells,suffer from the drawbacks of high cost and low yield yet.Cell-derived nanovesicles acquired through mechanical extrusion exhibit favorable biomimetic properties similar to exosomes,enabling them to efficiently encapsulate substantial quantities of therapeutic proteins.In this study,we observed that JAM-A,an adhesion protein,resulted in a significantly increased the adhesion and resilience of dermal papilla cells to form snap structures against damage caused by dihydrotestosterone and macrophages,thereby facilitating the process of hair regrowth in cases of AGA.Consequently,adipose-derived stem cells were modified to overexpress JAM-A to produce engineered JAM-A overexpressing nanovesicles(JAM-A^(OE)@NV).The incorporation of JAM-A^(OE)@NV into a thermosensitive hydrogel matrix(JAM-A^(OE)@NV Gel)to effectively addresses the limitations associated with the short half-life of JAM-A^(OE)@NV,and resulted in the achievement of a sustained-release profile for JAM-A^(OE)@NV.The physicochemical characteristics of the JAM-A^(OE)@NV Gel were analyzed and assessed for its efficacy in promoting hair regrowth in vivo and vitro.The JAM-A^(OE)@NV Gel,thus,presents a novel therapeutic approach and theoretical framework for promoting the treatment of low cell adhesion diseases similar to AGA.

Qinghai-tibetan plateau peatland sustainable utilization under anthropogenic disturbances and climate change

Often referred to as the“Third Pole,”China’s Qinghai-Tibetan Plateau developed large amounts of peatland owing to its unique alpine environment.As a renewable resource,peat helps to regulate the climate as well as performing other important functions.However,in recent years,intensifying climate change and anthropogenic disturbances have resulted in peatland degradation and consequently made sustainable development of peatland more difficult.This review summarizes peatland ecological and economic functions,including carbon sequestration,biodiversity conservation,energy supplies,and ecotourism.It identifies climate change and anthropogenic disturbances as the two key factors attributing to peatland degradation and ecosystem carbon loss.Current problems in environmental degradation and future challenges in peatland management under the effects of global warming are also discussed and highlighted.

Powerful supercontinuum vortices generated by femtosecond vortex beams with thin plates

We demonstrate numerically and experimentally the generation of powerful supercontinuum vortices from femtosecond vortex beams by using multiple thin fused silica plates.The supercontinuum vortices are shown to preserve the vortex phase profile of the initial beam for spectral components ranging from 500 nm to 1200 nm.The transfer of the vortex phase profile results from the inhibition of multiple filamentation and the preservation of the vortex ring with relatively uniform intensity distribution by means of the thin-plate scheme,where the supercontinuum is mainly generated from the self-phase modulation and self-steepening effects.Our scheme works for vortex beams with different topological charges,which provides a simple and effective method to generate supercontinuum vortices with high power.

Intensity modulation of filaments by shaped laser pulses in fused silica

We show the intensity control of filamentation in fused silica by temporally shaping the femtosecond laser pulse.The arbitrary control of filamentation intensity has been obtained by the feedback control based on the genetic algorithm,and the peak intensity of filament has changed from about 670 to around 2100(charge-coupled device counts).This modulation is in qualitative agreement with the simulation results.It is shown that the control of the intensity is realized by modulating the peak power of the shaped pulse.