AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP ...AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain.展开更多
To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed thi...To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed this paper by Shah et al,and found that promising as it is,this study has some methodological shortcomings,such as:cross-sectional nature of the study,lack of initial evaluations of quality of life and regular follow-ups to determine the dynamics and real directions of changes in quality of life.We therefore concluded that the results of the study by Shah et al are biased and,although very promising,should not be considered as scientifically relevant.展开更多
文摘AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain.
文摘To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis(World J Gastroenterol 2010;16:4066-4071).We analyzed and discussed this paper by Shah et al,and found that promising as it is,this study has some methodological shortcomings,such as:cross-sectional nature of the study,lack of initial evaluations of quality of life and regular follow-ups to determine the dynamics and real directions of changes in quality of life.We therefore concluded that the results of the study by Shah et al are biased and,although very promising,should not be considered as scientifically relevant.
