Despite recent advances in medical and surgical treatments,surgical resection remains the only curative option for patients with colorectal liver metastasis(CRLM).Unfortunately,only a minority of patients with CRLM ar...Despite recent advances in medical and surgical treatments,surgical resection remains the only curative option for patients with colorectal liver metastasis(CRLM).Unfortunately,only a minority of patients with CRLM are candidates for liver resection.The 5-year survival of patients with liver-only disease and deemed unresectable is difficult to quantify but likely ranges around 5 to 10%.Since 2013,a few studies have shown that liver transplantation(LT)is feasible for selected patients with unresectable CRLM(1,2).Recently,the Oslo University Hospital LT group has published their latest results with modified selection criteria and should be congratulated for their efforts.Nevertheless,the evidence available is still developing.For example,currently,there is a lack of robust evidence supporting the widespread use of LT for CRLM outside Norway,a particular region in terms of graft scarcity.展开更多
Several prognostic liver transplant-related risk scores for hepatocellular carcinoma(HCC)have been developed in recent years.The most prominent scores,displayed in Table 1,are based exclusively on HCC-related variable...Several prognostic liver transplant-related risk scores for hepatocellular carcinoma(HCC)have been developed in recent years.The most prominent scores,displayed in Table 1,are based exclusively on HCC-related variables(1-6).Given that non-HCC-related variables can also influence post-transplant outcomes,Goldberg et al.sought to develop a continuous risk score predicting post-transplant survival for patients using both HCC-and non-HCC-related variables(1).展开更多
文摘Despite recent advances in medical and surgical treatments,surgical resection remains the only curative option for patients with colorectal liver metastasis(CRLM).Unfortunately,only a minority of patients with CRLM are candidates for liver resection.The 5-year survival of patients with liver-only disease and deemed unresectable is difficult to quantify but likely ranges around 5 to 10%.Since 2013,a few studies have shown that liver transplantation(LT)is feasible for selected patients with unresectable CRLM(1,2).Recently,the Oslo University Hospital LT group has published their latest results with modified selection criteria and should be congratulated for their efforts.Nevertheless,the evidence available is still developing.For example,currently,there is a lack of robust evidence supporting the widespread use of LT for CRLM outside Norway,a particular region in terms of graft scarcity.
文摘Several prognostic liver transplant-related risk scores for hepatocellular carcinoma(HCC)have been developed in recent years.The most prominent scores,displayed in Table 1,are based exclusively on HCC-related variables(1-6).Given that non-HCC-related variables can also influence post-transplant outcomes,Goldberg et al.sought to develop a continuous risk score predicting post-transplant survival for patients using both HCC-and non-HCC-related variables(1).
