The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorgan...The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorganisms,immune and other stromal cells,and extracellular matrices.The orchestration of these components intricately contributes to tumor evolution and shapes responses to cancer treatment(Figure 1).A better understanding of the tumor microenvironment is critical to elucidate the etiology of cancer and develop more efficient therapeutic strategies.展开更多
基金supported in part by the Cancer Research UK Cancer Grand Challenge Award(6340201/A27140)NIH grant(R01 CA248857)+1 种基金T.U.was supported by NIH grant R50 CA27412a Brigham and Women’s Hospital Faculty Career Development Award,an Investigator Initiated Grant from the American Institute for Cancer Research(AICR),a Prevent Cancer Foundation Fellowship,and the Harvey V.Fineberg Fellowship in Cancer Prevention from Harvard T.H.Chan School of Public Health.S.U.was supported by a grant from the Uehara Memorial Foundation.S.O.is an American Cancer Society Clinical Research Professor。
文摘The tumor microenvironment represents a dynamic and multifaceted milieu characterized by the complex interactions of diverse cellular and non-cellular constituents.1,2 These constituents include tumor cells,microorganisms,immune and other stromal cells,and extracellular matrices.The orchestration of these components intricately contributes to tumor evolution and shapes responses to cancer treatment(Figure 1).A better understanding of the tumor microenvironment is critical to elucidate the etiology of cancer and develop more efficient therapeutic strategies.
