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Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis
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作者 Naoki Kondo Katsumitsu Arai +6 位作者 Takahiro Netsu tomotake kanai Hiroshige Sano Go Okumura Yasufumi Kijima Junichi Fujisawa Naoto Endo 《Open Journal of Rheumatology and Autoimmune Diseases》 2017年第1期46-52,共7页
To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. T... To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively 展开更多
关键词 TOCILIZUMAB RHEUMATOID ARTHRITIS REACTIVE Oxygen Species Disease Activity SCORE 28
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