New chiral gamino alcohols 1-4 were synthesized and applied in the asymmetric addition of diethylzinc to aldehydes to give sec-alcohol with up to 94.0% enantiomeric excess.
The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsun...The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).展开更多
An enantioselective synthetic route to (+)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1a and (-)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1b was developed from (S)-(-)-alpha -cyclocitral 8a and...An enantioselective synthetic route to (+)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1a and (-)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1b was developed from (S)-(-)-alpha -cyclocitral 8a and (R)-(+)-alpha -cyclocitral 8b.展开更多
First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of be...First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol.展开更多
基金Hong Kong Polytechnic University for the financial support.
文摘New chiral gamino alcohols 1-4 were synthesized and applied in the asymmetric addition of diethylzinc to aldehydes to give sec-alcohol with up to 94.0% enantiomeric excess.
基金We are grateful to the National Natural Science Foundation of China(No.2017223)for financial support
文摘The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).
基金the National Natural Science Foundation of China (No. 29372050)
文摘An enantioselective synthetic route to (+)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1a and (-)-13-acetyl-12-hydroxy-podocarpane-8,11,13-triene-7-one 1b was developed from (S)-(-)-alpha -cyclocitral 8a and (R)-(+)-alpha -cyclocitral 8b.
基金We are grateful to the National Natural Science Foundation of China (No. 29372050) for financial support.
文摘First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of ACABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol.
