Disqualifying Medical Conditions of Flying Personnel in Chinese Army and Air Force

After inpatient aircrews of Chinese Army and Air Force are treated at local hospitals, their health status will be evaluated. If it is aeronautically adaptable, the conclusion would be flying qualification; if it may impact the flight safety or the flight environment may aggravate

Morphology and ontogeny of dendritic cells in rats at different development periods

AIM:To study the morphology and ontogeny of dendritic cells of Peyer's patches in rats at different development periods. METHODS:The morphometric and flow cytometric analyses were performed to detect all the parameters of villous-crypts axis and the number of OX62+DC, OX62+CD4+SIRP+DC,and OX62+CD4-SIRP-DC in the small intestine in different groups of rats.The relationship between the parameters of villous-axis and the number of DC and DC subtype were analyzed. RESULTS:All morphometric parameters changed significantly with the development of pups in the different age groups(F=10.751,12.374,16.527, 5.291,3.486;P=0.000,0.000,0.000,0.001,0.015). Villous height levels were unstable and increased from 115.24μm to 140.43μm as early as 3 wk postpartum. Villous area increased significantly between 5 and 7 wk postpartum,peeked up to 13 817.60μm2 at 7 wk postpartum.Villous height and crypt depth ratios were relatively stable and increased significantly from 2.80±1.01 to 4.54±1.56,9-11 wk postpartum.The expression of OX62+DC increased from 33.30%± 5.80%to 80%±17.30%,3-11 wk postpartum(F=5.536,P=0.0013).OX62+CD4+SIRP+DC subset levels detected in single-cell suspensions of rat total Peyer's patch dendritic cells(PP-DCs)increased significantly from 30.73%±5.16%to 35.50%±4.08%,5-7 wk postpartum and from 34.20%±1.35%to 43.60%± 2.07%9-11 wk postpartum(F=7.216,P=0.005). CONCLUSION:This study confirms the agerelated changes in villous-crypt axis differentiation in the small intestine.Simultaneously,there are also development and maturation in rat PP-DCs phenotypic expression.Furthermore,the morphological changes of intestinal mucosa and the development of immune cells(especially DC)peaked at 9-11 wk postpartum, indicating that the intestinal mucosae reached a relatively mature state at 11 wk postpartum.

A Novel Mutation of Notch homolog protein 2 gene in a Chinese Family with Hajdu-Cheney Syndrome

Hajdu-Cheney syndrome （HCS） is a rare disorder which is characterized by developmental delay, craniofacial anomalies, congenital heart defects, hearing deficit, polycystic kidneys, and bone abnormalities, including progressive osteoporosis, acroosteolysis, wormian bones, and abnormal bonefractures.

A novel hypomorphic ζ-chain-associated protein tyrosine kinase 70 kDa mutation with normal CD8+ T cells count

To the Editor:The z-chain-associated protein tyrosine kinase 70 kDa(ZAP70)deficiency is a rare autosomal recessive primary immunodeficiency characterized by absent CD8+T cells and non-functional CD4+T cells.[1]According to current reports,approximately 18 pathogenic ZAP70 mutations have been identified in less than 30 patients.[1-4]ZAP70 deficiency always results in recurrent bacterial,viral,and opportunistic infections,diarrhea,and autoimmune diseases.Distinctively,ZAP70 hypomorphic mutations appear to have observable clinical heterogeneity,such as Epstein-Barr virus-associated lymphoproliferative disorder/lymphoma,late-onset immunodeficiency,[3]and silent brain infarcts.[5]Hence,next-generation sequencing technology might be the predominant diagnostic approach.