Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticit...Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticity,modulating oxidative stress,reducing neuronal apoptosis,and adjusting cellular autophagy.This paper summarizes researches on the mechanisms of acupuncture treatment for vD over the past decade,aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.展开更多
Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the...Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the prolactin's effects on erecti on of the penile tip and base,with a cross-secti onal study of 135 patie nts with erectile dysfuncti on,based on scores of M21 on the In ternational Index of Erectile Function-5.All patients were tested for nocturnal penile tumescenee,blood pressure,serum glucose,total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,luteinizing hormone,follicle-stimulating hormone,prolactin,estradiol,testosterone,and progesterone.Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base.We found no obvious relati on ship between erection time at penile tip and prolactin levels,but observed a negative correlation between base erection time and prolactin level(hazard ratio:-2.68;95%confidence interval[Cl]:-5.13-0.22).With increasing prolactin concentration,multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results(hazard ratio:-3.10;95%Cl:-7.96-1.77;P<0.05).Our data indicate that prolactin inhibits penile erection,particularly at the penile base.In addition,when the effective erection time of the penile base lasts longer than 10 min,prolactin has a more obvious inhibitory effect on penile base erection.展开更多
基金Supported by National Natural Science Foundation of ChinaGeneral Program:82074530Heilongjiang Provincial Natural Science Foundation Project:ZD2021H007Heilongjiang Provincial Traditional Chinese Medicine Research Project:ZHY2023-189,ZHY2023-209。
文摘Acupuncture can intervene with and treat vascular dementia(VD)through multiple targets and pathways.The mechanisms of its action involve inhibiting central inflammatory responses,regulating neuronal synaptic plasticity,modulating oxidative stress,reducing neuronal apoptosis,and adjusting cellular autophagy.This paper summarizes researches on the mechanisms of acupuncture treatment for vD over the past decade,aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.
基金This work was supported by the National Nature Science Foundation of China(No.81670625 and No.81470969)the Shandong Province Natural Science Foundation(No.ZR2017BH104,No.ZR2018MH006,No.ZR2018BH007 and No.ZR2015PH023)the Youth Foundation and Ybuth Talent Foundation of the Second Hospital of Shandong University(No.2018YT32 and No.Y2015010038).
文摘Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the prolactin's effects on erecti on of the penile tip and base,with a cross-secti onal study of 135 patie nts with erectile dysfuncti on,based on scores of M21 on the In ternational Index of Erectile Function-5.All patients were tested for nocturnal penile tumescenee,blood pressure,serum glucose,total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,luteinizing hormone,follicle-stimulating hormone,prolactin,estradiol,testosterone,and progesterone.Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base.We found no obvious relati on ship between erection time at penile tip and prolactin levels,but observed a negative correlation between base erection time and prolactin level(hazard ratio:-2.68;95%confidence interval[Cl]:-5.13-0.22).With increasing prolactin concentration,multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results(hazard ratio:-3.10;95%Cl:-7.96-1.77;P<0.05).Our data indicate that prolactin inhibits penile erection,particularly at the penile base.In addition,when the effective erection time of the penile base lasts longer than 10 min,prolactin has a more obvious inhibitory effect on penile base erection.
