AIM:To investigate the luminal esophageal temperature(LET) at the time of delivery of energy for pulmonary vein isolation(PVI).METHODS:This study included a total of 110 patients with atrial fibrillation who underwent...AIM:To investigate the luminal esophageal temperature(LET) at the time of delivery of energy for pulmonary vein isolation(PVI).METHODS:This study included a total of 110 patients with atrial fibrillation who underwent their first PVI procedure in our laboratory between March 2010 and February 2011.The LET was monitored in all patients.We measured the number of times that LET reached the cut-off temperature,the time when LET reached the cut-off temperature,the maximum temperature(T max) of the LET,and the time to return to the original preenergy delivery temperature once the delivery of energy was stopped.RESULTS:Seventy-eight patients reached the cut-off temperature.It took 6 s at the shortest time for the LET to reach the cut-off temperature,and 216.5 ± 102.9 s for the temperature to return to the level before the de-livery of energy.Some patients experienced a transient drop in the LET(TDLET) just before energy delivery.Ablation at these sites always produced a rise to the LET cut-off temperature.TDLET was not observed at sites where the LET did not rise.Thus,the TDLET before the energy delivery was useful to distinguish a high risk of esophageal injury before delivery of energy.CONCLUSION:Sites with a TDLET before energy delivery should be ablated with great caution or,perhaps,not at all.展开更多
AIM:To evaluate the effects of eicosapentaenoic acid(EPA) on regional arterial stiffness assessed by strain rate using tissue Doppler imaging.METHODS:Nineteen eligible patients were prospectively studied(mean age 62 &...AIM:To evaluate the effects of eicosapentaenoic acid(EPA) on regional arterial stiffness assessed by strain rate using tissue Doppler imaging.METHODS:Nineteen eligible patients were prospectively studied(mean age 62 ± 8 years,68% men).Subjects with large vessel complications and/or diabetes mellitus were excluded.The strain rate of the ascending aorta was measured by tissue Doppler imaging as an index of regional arterial stiffness,and brachialankle pulse wave velocity(baPWV) was measured as an index of degree of systemic arteriosclerosis.These indices were compared before and after administration of EPA at 1800 mg/d for one year.RESULTS:The plasma concentration of EPA increased significantly after EPA administration(3.0% ± 1.1% to 8.5% ± 2.9%,P 【 0.001).There were no significant changes in baPWV(1765 ± 335 cm/s to 1745 ± 374 cm/s),low-density lipoprotein cholesterol levels(114 ± 29 mg/dL to 108 ± 28 mg/dL),or systolic blood pressure(131 ± 16 mmHg to 130 ± 13 mmHg) before and after EPA administration.In contrast,the strain rate was significantly increased by administration of EPA(19.2 ± 5.6 s-1,23.0 ± 6.6 s-1,P 【 0.05).CONCLUSION:One year of administration of EPA resulted in an improvement in regional arterial stiffness which was independent of blood pressure or serum cholesterol levels.展开更多
文摘AIM:To investigate the luminal esophageal temperature(LET) at the time of delivery of energy for pulmonary vein isolation(PVI).METHODS:This study included a total of 110 patients with atrial fibrillation who underwent their first PVI procedure in our laboratory between March 2010 and February 2011.The LET was monitored in all patients.We measured the number of times that LET reached the cut-off temperature,the time when LET reached the cut-off temperature,the maximum temperature(T max) of the LET,and the time to return to the original preenergy delivery temperature once the delivery of energy was stopped.RESULTS:Seventy-eight patients reached the cut-off temperature.It took 6 s at the shortest time for the LET to reach the cut-off temperature,and 216.5 ± 102.9 s for the temperature to return to the level before the de-livery of energy.Some patients experienced a transient drop in the LET(TDLET) just before energy delivery.Ablation at these sites always produced a rise to the LET cut-off temperature.TDLET was not observed at sites where the LET did not rise.Thus,the TDLET before the energy delivery was useful to distinguish a high risk of esophageal injury before delivery of energy.CONCLUSION:Sites with a TDLET before energy delivery should be ablated with great caution or,perhaps,not at all.
文摘AIM:To evaluate the effects of eicosapentaenoic acid(EPA) on regional arterial stiffness assessed by strain rate using tissue Doppler imaging.METHODS:Nineteen eligible patients were prospectively studied(mean age 62 ± 8 years,68% men).Subjects with large vessel complications and/or diabetes mellitus were excluded.The strain rate of the ascending aorta was measured by tissue Doppler imaging as an index of regional arterial stiffness,and brachialankle pulse wave velocity(baPWV) was measured as an index of degree of systemic arteriosclerosis.These indices were compared before and after administration of EPA at 1800 mg/d for one year.RESULTS:The plasma concentration of EPA increased significantly after EPA administration(3.0% ± 1.1% to 8.5% ± 2.9%,P 【 0.001).There were no significant changes in baPWV(1765 ± 335 cm/s to 1745 ± 374 cm/s),low-density lipoprotein cholesterol levels(114 ± 29 mg/dL to 108 ± 28 mg/dL),or systolic blood pressure(131 ± 16 mmHg to 130 ± 13 mmHg) before and after EPA administration.In contrast,the strain rate was significantly increased by administration of EPA(19.2 ± 5.6 s-1,23.0 ± 6.6 s-1,P 【 0.05).CONCLUSION:One year of administration of EPA resulted in an improvement in regional arterial stiffness which was independent of blood pressure or serum cholesterol levels.
