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Role of chronic hypoxia and hypoxia inducible factor in kidney disease 被引量:11
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作者 Masaomi Nangaku Hiroshi Nishi toshio miyata 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第3期257-264,共8页
Cells are endowed with a defensive mechanism against hypoxia, namely hypoxia-inducible factor (HIF) andhypoxia-responsive element (HRE). Under hypoxic conditions, activation of HIF leads to expression of a variety... Cells are endowed with a defensive mechanism against hypoxia, namely hypoxia-inducible factor (HIF) andhypoxia-responsive element (HRE). Under hypoxic conditions, activation of HIF leads to expression of a variety of adaptive genes with HRE in a coordinated manner. The amount of HIF is regulated principally by the rate of degradation through post-translational modification by prolyl hydroxylases. Experimental studies utilizing HIF stimulating agents have been effective in a variety of kidney disease models, demonstrating that the HIF-HRE pathway is a promising target of future therapeutic approaches. 展开更多
关键词 chronic kidney disease hypoxia inducible factor prolyl hydroxylases ISCHEMIA ANGIOTENSIN
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