A 58-year-old woman complicated with autoimmune diseases of myasthenia gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an irregular black macule on her bilateral major labia, which was diag...A 58-year-old woman complicated with autoimmune diseases of myasthenia gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an irregular black macule on her bilateral major labia, which was diagnosed as malignant melanoma. The melanoma lesion involving the vagina, uterus, and ventral side of rectum was not operable and was treated with nivolumab and concurrent radiotherapy with good control of the MG. This resulted in remarkable tumor shrinkage, possibly due to synergistic effects of both treatments. To our knowledge, few reports have described the effectiveness of combination therapy with nivolumab and radiation for malignant melanoma. The present case showed an enhanced anti-tumor effect with combination therapy.展开更多
The brookite-phase TiO{in2} was prepared by a hydrothermal synthesis of titanium chloride solution. The thermolysis time and the pH value of the solution were controlled during the synthesis. X-ray diffraction experim...The brookite-phase TiO{in2} was prepared by a hydrothermal synthesis of titanium chloride solution. The thermolysis time and the pH value of the solution were controlled during the synthesis. X-ray diffraction experiments showed that TiO{in2} powders partially containing the brookite-phase were successfully obtained. A great amount of OH{su\t-} in the reaction solution was found to be important to obtain the brookite phase because the intermediate complex leading to the brookite phase consumes more OH{su\t-} than other phases like the rutile.展开更多
文摘A 58-year-old woman complicated with autoimmune diseases of myasthenia gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an irregular black macule on her bilateral major labia, which was diagnosed as malignant melanoma. The melanoma lesion involving the vagina, uterus, and ventral side of rectum was not operable and was treated with nivolumab and concurrent radiotherapy with good control of the MG. This resulted in remarkable tumor shrinkage, possibly due to synergistic effects of both treatments. To our knowledge, few reports have described the effectiveness of combination therapy with nivolumab and radiation for malignant melanoma. The present case showed an enhanced anti-tumor effect with combination therapy.
文摘The brookite-phase TiO{in2} was prepared by a hydrothermal synthesis of titanium chloride solution. The thermolysis time and the pH value of the solution were controlled during the synthesis. X-ray diffraction experiments showed that TiO{in2} powders partially containing the brookite-phase were successfully obtained. A great amount of OH{su\t-} in the reaction solution was found to be important to obtain the brookite phase because the intermediate complex leading to the brookite phase consumes more OH{su\t-} than other phases like the rutile.
