A Single Hypoxic Event Ameliorates Pilocarpine Induced Hyperkinetic Movements in Planaria

Intermittent hypoxia or hypoxia therapy is exposing an individual to oxygenation conditions that are below atmospheric levels in a planned or acute timeframe. Hypoxia therapy is a potentially novel therapeutic strategy for a variety of pathologies including: mitochondrial disorders, exercise training, and mild cognitive impairments. Mitochondrial dysfunction, hyperkinetic movements, and cognitive impairments are hallmarks of seizures and status epilepticus (SE). A seizure can be considered uncontrolled electrical activity in the brain and SE is a seizure lasting more than 30 minutes, or multiple seizures without regaining consciousness in between. We examined the possibility of using the Pilocarpine model for seizure like activity on brown planaria (Dugesia tigrine). Pilocarpine is a muscarinic acetylcholine receptor agonist capable of creating seizure related brain damage. We utilized 5 mM dosages of pilocarpine and then measured open field behaviour for 3 minutes. Mobility and aversive hyperkinetic movements were observed throughout the measurement phase. After exposure to 5 mM pilocarpine, the planaria displayed behaviours consistent with seizures (e.g. aversive hyperkinetic movements and decreased mobility). Additionally, we measured the effects of an acute hypoxic event on Planaria behaviour. We used 25% carbonated water to create a hypoxic environment for the planaria and then measured mobility and hyperkinetic movements for 3 minutes. We noted that exposure to the hypoxic en-vironment produced no changes in behaviour. However, the aversive hyperkinetic move-ments produced with pilocarpine administration were completely absent when a brief (3 minutes) hypoxic episode followed the pilocarpine exposure (p < 0.05). Aversive behav-iours remained present when the ordering of pilocarpine and hypoxia were counterbal-anced. This ordering effect was consistent across 40 trials. Further evaluation of the pilo-carpine seizure model and intermittent hypoxia on planarian behaviour is warranted.

Quantification of the Diminishing Earth’s Magnetic Dipole Intensity and Geomagnetic Activity as the Causal Source for Global Warming within the Oceans and Atmosphere

Quantitative analyses of actual measurements rather than modeling have shown that “global warming” has been heterogeneous over the surface of the planet and temporally non-linear. Residual regression analyses by Soares (2010) indicated increments of increased temperature precede increments of CO2 increase. The remarkably strong negative correlation (r = -0.99) between the earth’s magnetic dipole moment values and global CO2-temperature indicators over the last ~30 years is sufficient to be considered causal if contributing energies were within the same order of magnitude. Quantitative convergence between the energies lost by the diminishing averaged geomagnetic field strength and energies gained within the ocean-atmosphere interface satisfy the measured values for increased global temperature and CO2 release from sea water. The pivotal variable is the optimal temporal unit employed to estimate the total energies available for physical-chemical reactions. The positive drift in averaged amplitude of geomagnetic activity over the last 100 years augmented this process. Contributions from annual CO2 from volcanism and shifts in averaged geomagnetic activity, lagged years before the measured global temperature-CO2 values, are moderating variables for smaller amplitude perturbations. These results indicated that the increase in CO2 and global temperatures are primarily caused by major geophysical factors, particularly the diminishing total geomagnetic field strength and increased geomagnetic activity, but not by human activities. Strategies for adapting to climate change because of these powerful variables may differ from those that assume exclusive anthropomorphic causes.

Quantification of the Diminishing Earth’s Magnetic Dipole Intensity and Geomagnetic Activity as the Causal Source for Global Warming within the Oceans and Atmosphere

Quantitative analyses of actual measurements rather than modeling have shown that “global warming” has been heterogeneous over the surface of the planet and temporally non-linear. Residual regression analyses by Soares (2010) indicated increments of increased temperature precede increments of CO2 increase. The remarkably strong negative correlation (r = -0.99) between the earth’s magnetic dipole moment values and global CO2-temperature indicators over the last ~30 years is sufficient to be considered causal if contributing energies were within the same order of magnitude. Quantitative convergence between the energies lost by the diminishing averaged geomagnetic field strength and energies gained within the ocean-atmosphere interface satisfy the measured values for increased global temperature and CO2 release from sea water. The pivotal variable is the optimal temporal unit employed to estimate the total energies available for physical-chemical reactions. The positive drift in averaged amplitude of geomagnetic activity over the last 100 years augmented this process. Contributions from annual CO2 from volcanism and shifts in averaged geomagnetic activity, lagged years before the measured global temperature-CO2 values, are moderating variables for smaller amplitude perturbations. These results indicated that the increase in CO2 and global temperatures are primarily caused by major geophysical factors, particularly the diminishing total geomagnetic field strength and increased geomagnetic activity, but not by human activities. Strategies for adapting to climate change because of these powerful variables may differ from those that assume exclusive anthropomorphic causes.

Identifying Factors Which Contribute to the Magnitude of Excess Correlations between Magnetic Field-Paired Volumes of Water

Excess correlations, one of the quantitative demonstrations of “entanglement”, have been experimentally demonstrated as spontaneous shifts in photon properties and molecular interactions. The magnitudes of the excess correlations have been enhanced experimentally for photon emissions and proton densities in aqueous solutions when the loci containing these physical chemical reactions shared circular magnetic fields whose angular velocities were always changing. In the present experiment, quantities of spring water each placed in one of two loci (local or non-local) separated by 100 or 10,000 m were exposed simultaneously to toroidal magnetic fields within a paradigm that has been shown to produce conspicuous excess correlations in shifts of photon emissions, pH in spring water, and human brain activity as inferred by electroencephalography. The non-local area that was not injected with proton donors displayed a reliable shift in pH when the local area was serially injected with small aliquots of protons but only during the presentations of the field parameters known to produce “entanglement”. The effect was most obvious when the global geomagnetic activity was less than Kp < 3. The probability is high that convergent similarities in the magnitudes of the local geomagnetic intensities of the two loci enhance the strength of the excess correlations. These results suggest that a minimal energy and inexpensive system, not involving classical electromagnetic transmission through a medium, but influenced by the global geomagnetic field activity, could be employed to generalize and superpose information between two non-local spaces.

Non-Local pH Shifts and Shared Changing Angular Velocity Magnetic Fields: Discrete Energies and the Importance of Point Durations

Macroscopic productions of “non-locality” or “excess correlations” of dynamic changes within media between two spaces could be utilized as alternative communication systems. Previous experiments have shown that injections of a weak acid within one of two volumes of spring water sharing the same patterned circular magnetic fields with changing angular accelerations separated by non-traditional (5 m) distances were associated with opposite (basic) shifts in pH within the non-injected, non-local volume. In the present experiments, employing a different technology, pairs of beakers separated by 1 m containing either 25 cc, 50 cc, or 100 cc of spring water were placed within toroids generating weak (30, 300 nT) changing acceleration magnetic fields with 1 ms, 2 ms, or 3 ms point durations or a field whose point durations changed. When a proton source (weak acid) was injected into one beaker (local) pH shifts in the other (non-local) beaker exhibit increased acidity for the 3 ms point duration but increased alkalinity for the 1 ms duration. Neither intermittent point durations nor variable point durations for the same volumes of water placed between the two magnetic field-coupled beakers exhibited significant changes from baseline. Contingent upon the point duration of the applied field, the pH shift was consistent with a fixed quantity of decreased free protons (increased pH) or increased protons (decreased pH) in the non-local beakers. The opposite directions of the pH shifts at 1 ms and 3 ms that correspond to quantitative cosmological solutions for electrons and protons suggest these results may reflect a fundamental physical process.