Based on atomic force microscopy technique, we found that the chon- drocytes exhibits stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid...Based on atomic force microscopy technique, we found that the chon- drocytes exhibits stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid exuding out from the cells during deformation plays the most important role in the stress relax- ation. We applied the inverse finite element analysis technique to determine nec- essary material parameters for porohyperelastic （PHE） model to simulate stress relaxation behavior as this model is proven capable of capturing the non-linear behavior and the fluid-solid interaction during the stress relaxation of the single chondrocytes. It is observed that PHE model can precisely capture the stress re- laxation behavior of single chondrocytes and would be a suitable model for cell biomechanics.展开更多
基金supported by ARC Future Fellowship Project(FT100100172)QUT Postgraduate Research Scholarship
文摘Based on atomic force microscopy technique, we found that the chon- drocytes exhibits stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid exuding out from the cells during deformation plays the most important role in the stress relax- ation. We applied the inverse finite element analysis technique to determine nec- essary material parameters for porohyperelastic （PHE） model to simulate stress relaxation behavior as this model is proven capable of capturing the non-linear behavior and the fluid-solid interaction during the stress relaxation of the single chondrocytes. It is observed that PHE model can precisely capture the stress re- laxation behavior of single chondrocytes and would be a suitable model for cell biomechanics.
