The consideration of the time-varying covariate and time-varying coefficient effect in survival models are plausible and robust techniques. Such kind of analysis can be carried out with a general class of semiparametr...The consideration of the time-varying covariate and time-varying coefficient effect in survival models are plausible and robust techniques. Such kind of analysis can be carried out with a general class of semiparametric transformation models. The aim of this article is to develop modified estimating equations under semiparametric transformation models of survival time with time-varying coefficient effect and time-varying continuous covariates. For this, it is important to organize the data in a counting process style and transform the time with standard transformation classes which shall be applied in this article. In the situation when the effect of coefficient and covariates change over time, the widely used maximum likelihood estimation method becomes more complex and burdensome in estimating consistent estimates. To overcome this problem, alternatively, the modified estimating equations were applied to estimate the unknown parameters and unspecified monotone transformation functions. The estimating equations were modified to incorporate the time-varying effect in both coefficient and covariates. The performance of the proposed methods is tested through a simulation study. To sum up the study, the effect of possibly time-varying covariates and time-varying coefficients was evaluated in some special cases of semiparametric transformation models. Finally, the results have shown that the role of the time-varying covariate in the semiparametric transformation models was plausible and credible.展开更多
In this paper, we provide and analyze a new scaled conjugate gradient method and its performance, based on the modified secant equation of the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method and on a new modified nonmo...In this paper, we provide and analyze a new scaled conjugate gradient method and its performance, based on the modified secant equation of the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method and on a new modified nonmonotone line search technique. The method incorporates the modified BFGS secant equation in an effort to include the second order information of the objective function. The new secant equation has both gradient and function value information, and its update formula inherits the positive definiteness of Hessian approximation for general convex function. In order to improve the likelihood of finding a global optimal solution, we introduce a new modified nonmonotone line search technique. It is shown that, for nonsmooth convex problems, the proposed algorithm is globally convergent. Numerical results show that this new scaled conjugate gradient algorithm is promising and efficient for solving not only convex but also some large scale nonsmooth nonconvex problems in the sense of the Dolan-Moré performance profiles.展开更多
文摘The consideration of the time-varying covariate and time-varying coefficient effect in survival models are plausible and robust techniques. Such kind of analysis can be carried out with a general class of semiparametric transformation models. The aim of this article is to develop modified estimating equations under semiparametric transformation models of survival time with time-varying coefficient effect and time-varying continuous covariates. For this, it is important to organize the data in a counting process style and transform the time with standard transformation classes which shall be applied in this article. In the situation when the effect of coefficient and covariates change over time, the widely used maximum likelihood estimation method becomes more complex and burdensome in estimating consistent estimates. To overcome this problem, alternatively, the modified estimating equations were applied to estimate the unknown parameters and unspecified monotone transformation functions. The estimating equations were modified to incorporate the time-varying effect in both coefficient and covariates. The performance of the proposed methods is tested through a simulation study. To sum up the study, the effect of possibly time-varying covariates and time-varying coefficients was evaluated in some special cases of semiparametric transformation models. Finally, the results have shown that the role of the time-varying covariate in the semiparametric transformation models was plausible and credible.
文摘In this paper, we provide and analyze a new scaled conjugate gradient method and its performance, based on the modified secant equation of the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method and on a new modified nonmonotone line search technique. The method incorporates the modified BFGS secant equation in an effort to include the second order information of the objective function. The new secant equation has both gradient and function value information, and its update formula inherits the positive definiteness of Hessian approximation for general convex function. In order to improve the likelihood of finding a global optimal solution, we introduce a new modified nonmonotone line search technique. It is shown that, for nonsmooth convex problems, the proposed algorithm is globally convergent. Numerical results show that this new scaled conjugate gradient algorithm is promising and efficient for solving not only convex but also some large scale nonsmooth nonconvex problems in the sense of the Dolan-Moré performance profiles.
