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D2-40免疫组化分析用于鉴别Kaposi样血管内皮瘤和丛状血管瘤 被引量:6
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作者 Arai E. Kuramochi A. +1 位作者 tsuchida t. 董平 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第11期17-17,共1页
Background: Recent investigations have demonstrated the utility of the monoclonal antibody D2-40 as a marker for lymphatic endothelium. D2-40 can be used on formalin-fixed and paraf-fin-embedded materials. Our objecti... Background: Recent investigations have demonstrated the utility of the monoclonal antibody D2-40 as a marker for lymphatic endothelium. D2-40 can be used on formalin-fixed and paraf-fin-embedded materials. Our objective was to elucidate, using D2-40 immunohistochemistry, the differences among capillary hemangiomas, and especially between kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).We studied four cases of KHE, nine cases of TA, and 31 cases of other vascular tumors. Antibodies against CD31, CD34, factor VIII-related antigen, and GLUT1 were also applied. Results: In KHE, D2-40 was markedly reactive for three and partially for one of four cases in the peripheral area of Kaposi’s sarcoma-like proliferative capillaries and negative in the surrounding dilated vessels. In TA, D2-40 was partially positive in the surrounding dilated vessels and negative in cannonball-like proliferative capillaries. Conclusions: Our results suggest that D2-40 is a useful antibody for immunohistochemical discrimination between KHE and TA. In addition, the difference of immunostaining pattern of D2-40 is limited to the peripheral area of capillary proliferation and surrounding dilated vessels; therefore, it is suggested that KHE and TA may reflect different stages in the evolution of a single entity. Namely, they may originate from stem cells possessing the characteristics of both lymphatic and blood vessel endothelial lineages. 展开更多
关键词 免疫组化分析 D2-40 KAPOSI 血管内皮瘤 血管瘤病 丛状 毛细血管瘤 肉瘤样 淋巴内皮
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