Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dop...Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dopaminergic systems. Dopamine receptor D2 (DRD2) is the D2 subtype of the dopamine receptor of the G-protein coupled receptor family. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) in DRD2 gene on delay discounting. Methods: The participants consisted of 91 healthy Japanese people (66 males and 25 females with a mean age of 40.9 ± 6.9 years). Each participant completed the Kirby’s monetary choice questionnaire (MCQ) for delayed gain and donated a whole blood sample. Two SNPs (C957T (rs6277) and TaqI A (rs1800497)) in DRD2 were genotyped by using the DigiTag2 assay. SNP linear regression analyses with 100,000 permutations were conducted for the hyperbolic time-discount rate (k). Results: The SNP C957T showed a significant association;participants with more minor alleles (T) were more impulsive in intertemporal choice for delayed gain (multiplicity-corrected P = 0.041 with a small effect size). Conclusion: The variation in the DRD2 gene is associated with impulsive decision-making. This is the first study to demonstrate an association between DRD2 and impulsivity in intertemporal choice with a multiplicity-corrected significance.展开更多
Aim: The aim of this study is to examine the effect of walking 10,000 steps per day on depressive symptoms for the company employees and their spouses in Japan. Method: Subjects were recruited from the participants of...Aim: The aim of this study is to examine the effect of walking 10,000 steps per day on depressive symptoms for the company employees and their spouses in Japan. Method: Subjects were recruited from the participants of a walking campaign carried out by a Japanese company where the goal was to achieve 600,000 steps in 60 days. Among 221 subjects who participated in the campaign, 176 subjects (79.6%) agreed to participate in the present study. Sociodemographics and other information including depressive symptoms were assessed using a questionnaire. Result: Out of the 171 participants, 125 achieved the goal (73.1%). In the achiever’s group, the GHQ-12 score was significantly reduced at the end of the campaign compared with the non-achiever’s group. Exercise habit and the less overtime work (展开更多
To assess the correlation of renal volume measured on CT with aortic contrast enhancement on the hepatic arterial phase of dynamic CT, 64 consecutive patients (34 men, 30 women) were retrospectively examined. Renal vo...To assess the correlation of renal volume measured on CT with aortic contrast enhancement on the hepatic arterial phase of dynamic CT, 64 consecutive patients (34 men, 30 women) were retrospectively examined. Renal volumes were measured on CT. The aortic contrast enhancement was inversely correlated with renal medullary volume (r = -0.52, p 0.0001), and renal cortical volume (r = -0.3, p = 0.02). Renal volume may have inverse correlation with aortic contrast enhancement on the hepatic arterial phase of dynamic CT. This might call for adjustment of contrast material dose based in part on renal volume in the future.展开更多
文摘Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward in neuroeconomics. It is reportedly associated with the dopaminergic systems. Dopamine receptor D2 (DRD2) is the D2 subtype of the dopamine receptor of the G-protein coupled receptor family. The aim of this study was to explore the effect of single nucleotide polymorphisms (SNPs) in DRD2 gene on delay discounting. Methods: The participants consisted of 91 healthy Japanese people (66 males and 25 females with a mean age of 40.9 ± 6.9 years). Each participant completed the Kirby’s monetary choice questionnaire (MCQ) for delayed gain and donated a whole blood sample. Two SNPs (C957T (rs6277) and TaqI A (rs1800497)) in DRD2 were genotyped by using the DigiTag2 assay. SNP linear regression analyses with 100,000 permutations were conducted for the hyperbolic time-discount rate (k). Results: The SNP C957T showed a significant association;participants with more minor alleles (T) were more impulsive in intertemporal choice for delayed gain (multiplicity-corrected P = 0.041 with a small effect size). Conclusion: The variation in the DRD2 gene is associated with impulsive decision-making. This is the first study to demonstrate an association between DRD2 and impulsivity in intertemporal choice with a multiplicity-corrected significance.
文摘Aim: The aim of this study is to examine the effect of walking 10,000 steps per day on depressive symptoms for the company employees and their spouses in Japan. Method: Subjects were recruited from the participants of a walking campaign carried out by a Japanese company where the goal was to achieve 600,000 steps in 60 days. Among 221 subjects who participated in the campaign, 176 subjects (79.6%) agreed to participate in the present study. Sociodemographics and other information including depressive symptoms were assessed using a questionnaire. Result: Out of the 171 participants, 125 achieved the goal (73.1%). In the achiever’s group, the GHQ-12 score was significantly reduced at the end of the campaign compared with the non-achiever’s group. Exercise habit and the less overtime work (
文摘To assess the correlation of renal volume measured on CT with aortic contrast enhancement on the hepatic arterial phase of dynamic CT, 64 consecutive patients (34 men, 30 women) were retrospectively examined. Renal volumes were measured on CT. The aortic contrast enhancement was inversely correlated with renal medullary volume (r = -0.52, p 0.0001), and renal cortical volume (r = -0.3, p = 0.02). Renal volume may have inverse correlation with aortic contrast enhancement on the hepatic arterial phase of dynamic CT. This might call for adjustment of contrast material dose based in part on renal volume in the future.
