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Dodecylamine Derivative of Hydroxocobalamin Acts as a Potent Inhibitor of Cobalamin-Dependent Methionine Synthase in Mammalian Cultured COS-7 Cells 被引量:1
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作者 Tomohiro Bito Mariko Yasui +6 位作者 Toshio Iwaki Yukinori Yabuta tsuyoshi ichiyanagi Ryoichi Yamaji Yoshihisa Nakano Hiroshi Inui Fumio Watanabe 《Food and Nutrition Sciences》 2014年第14期1318-1325,共8页
We evaluated whether the dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent enzymes in an African green monkey kidney cell, COS-7. When the dodecylamine derivative (1.0 μmol... We evaluated whether the dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent enzymes in an African green monkey kidney cell, COS-7. When the dodecylamine derivative (1.0 μmol/L) did not show any cytotoxicity in the cultured cells, the derivative could not affect methylmalonyl-CoA mutase (holo-enzyme) activity, but significantly inhibit methionine synthase (holo-enzyme) activity in the cell homogenates of COS-7 grown in 1.0 μmol/L hydroxocobalamin-supplemented medium. An immunoblot analysis indicated that the dodecylamine derivative could not decrease the protein level of methionine synthase, but significantly inhibit the enzyme activity. 展开更多
关键词 DODECYLAMINE DERIVATIVE COBALAMIN COS-7 Cell Enzyme Inhibitor Hydroxocobalamin
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