目的:通过对既往5年内研究进行系统分析,评价2种微创治疗——PAIR(穿刺、抽吸、注入和再抽吸)技术和腹腔镜技术对肝囊型包虫病的临床安全性和有效性。方法:通过检索Medline、Embase、Web of science、Cochrane Library数据库2014～2018...目的:通过对既往5年内研究进行系统分析,评价2种微创治疗——PAIR(穿刺、抽吸、注入和再抽吸)技术和腹腔镜技术对肝囊型包虫病的临床安全性和有效性。方法:通过检索Medline、Embase、Web of science、Cochrane Library数据库2014～2018年5年内的临床研究,共10篇文献最终纳入本研究,其中4篇主要讨论PAIR治疗肝囊型包虫病的疗效,5篇文献主要讨论腹腔镜治疗肝囊型包虫病的疗效,1篇既有腹腔镜治疗,也有PAIR治疗,主要效应指标为治愈率、复发率、术后并发症。结果:汇总分析结果示腹腔镜手术治愈率为98.65%,PAIR治愈率为98.31%,两者差异无统计学意义(P>0.05)。对于肝囊型包虫病,2种治疗方法均有效(P=0.780)。在治疗后复发率方面,腹腔镜治疗复发率1.14%,PAIR治疗复发率0.42%,差异无统计学意义(P=0.210)。2种治疗方式均无死亡病例,而安全性方面,腹腔镜治疗后胆道瘘、囊腔感染发生率显著高于PAIR(8.78%比0.64%,P<0.001;3.72%比1.06%,P=0.018),过敏反应发生率显著低于PAIR(0比2.54%,P=0.005)。结论:对肝囊型包虫病外科治疗而言,PAIR技术和腹腔镜治疗是安全和有效的。2种微创治疗具有不同的术后并发症特点,腹腔镜治疗胆道瘘和感染更常见,PAIR患者则过敏反应多见。展开更多
AIM: To compare biofeedback-guided pelvic floor exercise therapy(BFT) with the use of oral polyethylene glycol(PEG) for the treatment of obstructive defecation.METHODS: A total of 88 subjects were assigned to treatmen...AIM: To compare biofeedback-guided pelvic floor exercise therapy(BFT) with the use of oral polyethylene glycol(PEG) for the treatment of obstructive defecation.METHODS: A total of 88 subjects were assigned to treatment with either BFT(n = 44) or oral PEG(n = 44). Constipation symptoms(including difficult evacuation, hard stool, digitation necessity, incomplete emptying sensation, laxative dependence, perianal pain at defecation, and constipation satisfaction), Wexner Scores, and quality of life scores were assessed after 1, 3, and 6 mo.RESULTS: At the 6 mo follow-up, the symptoms of the BFT group patients showed significantly greater improvements compared with the PEG group regarding difficult evacuation, hard stools, digitation necessity, laxative dependence, perianal pain at defecation, constipation satisfaction, Wexner Constipation Score, and quality of life score(P < 0.05). The quality of life score of the BFT group at the final follow-up time(6 mo) was 80 ± 2.2. After a complete course of training, improvements in the clinical symptoms of the BFT group were markedly improved(P < 0.05), and the Wexner Constipation Scores were greatly decreased compared with the oral PEG group(P < 0.05).CONCLUSION: We concluded that manometric biofeedback-guided pelvic floor exercise training is superior to oral polyethylene glycol therapy for obstructive defecation.展开更多
Background: The University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions are the two most frequently used liver graft preservation fluids. The present study aimed to compare their efficacy i...Background: The University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions are the two most frequently used liver graft preservation fluids. The present study aimed to compare their efficacy in end-stage hepatic alveolar echinococcosis patients who underwent ex-situ liver resection and autotransplantation (ELRA). Methods: A total of 81 patients received ELRA from August 2010 to March 2018. They were allocated into UW ( n = 48) and HTK groups ( n = 33) based on the type of solutions used. Demographic and operational data were retrospectively analyzed. Primary outcomes included 90-day mortality, incidence of early graft loss, primary dysfunction, and postoperative complications. Results: Demographic and operational characteristics were similarly distributed in the two groups. No statistically significant differences were observed with regard to 90-day mortality (12.77% vs. 12.12%) and early graft loss rate (8.51% vs. 9.09%) between the two groups. Patients in the UW and HTK groups showed a primary dysfunction rate of 27.66% and 27.27%, respectively. The UW group exhibited a higher incidence tendency of biliary complications, albeit with no statistical significance. Conclusions: This is the largest cohort study comparing the efficacy of the UW and HTK organ-preserving solutions in end-stage hepatic alveolar echinococcosis patients in ELRA settings. UW and HTK solutions presented similar efficacy and safety. A randomized clinical trial with larger scale is needed for further investigation in future clinical applications.展开更多
BACKGROUND The optimal approach for managing hepatic hemangioma is controversial.AIM To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution experience.MET...BACKGROUND The optimal approach for managing hepatic hemangioma is controversial.AIM To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution experience.METHODS A clinical grading system was retrospectively applied to 1171 patients with hepatic hemangioma from January 2002 to December 2018.Patients were classified into four groups based on the clinical grading system and treatment:(1)Observation group with score<4(Obs score<4);(2)Surgical group with score<4(Sur score<4);(3)Observation group with score≥4(Obs score≥4);and(4)Surgical group with score≥4(Sur score≥4).The clinico-pathological index and outcomes were evaluated.RESULTS There were significantly fewer symptomatic patients in surgical groups(Sur score≥4 vs Obs score≥4,P<0.001;Sur score<4 vs Obs score<4,χ^(2)=8.60,P=0.004;Sur score≥4 vs Obs score<4,P<0.001).The patients in Sur score≥4 had a lower rate of in need for intervention and total patients with adverse event than in Obs score≥4(P<0.001;P<0.001).Nevertheless,there was no significant difference in need for intervention and total patients with adverse event between the Sur score<4 and Obs score<4(P>0.05;χ^(2)=1.68,P>0.05).CONCLUSION This clinical grading system appeared as a practical tool for hepatic hemangioma.Surgery can be suggested for patients with a score≥4.For those with<4,follow-up should be proposed.展开更多
文摘目的:通过对既往5年内研究进行系统分析,评价2种微创治疗——PAIR(穿刺、抽吸、注入和再抽吸)技术和腹腔镜技术对肝囊型包虫病的临床安全性和有效性。方法:通过检索Medline、Embase、Web of science、Cochrane Library数据库2014～2018年5年内的临床研究,共10篇文献最终纳入本研究,其中4篇主要讨论PAIR治疗肝囊型包虫病的疗效,5篇文献主要讨论腹腔镜治疗肝囊型包虫病的疗效,1篇既有腹腔镜治疗,也有PAIR治疗,主要效应指标为治愈率、复发率、术后并发症。结果:汇总分析结果示腹腔镜手术治愈率为98.65%,PAIR治愈率为98.31%,两者差异无统计学意义(P>0.05)。对于肝囊型包虫病,2种治疗方法均有效(P=0.780)。在治疗后复发率方面,腹腔镜治疗复发率1.14%,PAIR治疗复发率0.42%,差异无统计学意义(P=0.210)。2种治疗方式均无死亡病例,而安全性方面,腹腔镜治疗后胆道瘘、囊腔感染发生率显著高于PAIR(8.78%比0.64%,P<0.001;3.72%比1.06%,P=0.018),过敏反应发生率显著低于PAIR(0比2.54%,P=0.005)。结论:对肝囊型包虫病外科治疗而言,PAIR技术和腹腔镜治疗是安全和有效的。2种微创治疗具有不同的术后并发症特点,腹腔镜治疗胆道瘘和感染更常见,PAIR患者则过敏反应多见。
基金Supported by Research Award Fund of First Affiliated Hospital of Xinjiang Medical University,Fund Serial No.2012YFY30
文摘AIM: To compare biofeedback-guided pelvic floor exercise therapy(BFT) with the use of oral polyethylene glycol(PEG) for the treatment of obstructive defecation.METHODS: A total of 88 subjects were assigned to treatment with either BFT(n = 44) or oral PEG(n = 44). Constipation symptoms(including difficult evacuation, hard stool, digitation necessity, incomplete emptying sensation, laxative dependence, perianal pain at defecation, and constipation satisfaction), Wexner Scores, and quality of life scores were assessed after 1, 3, and 6 mo.RESULTS: At the 6 mo follow-up, the symptoms of the BFT group patients showed significantly greater improvements compared with the PEG group regarding difficult evacuation, hard stools, digitation necessity, laxative dependence, perianal pain at defecation, constipation satisfaction, Wexner Constipation Score, and quality of life score(P < 0.05). The quality of life score of the BFT group at the final follow-up time(6 mo) was 80 ± 2.2. After a complete course of training, improvements in the clinical symptoms of the BFT group were markedly improved(P < 0.05), and the Wexner Constipation Scores were greatly decreased compared with the oral PEG group(P < 0.05).CONCLUSION: We concluded that manometric biofeedback-guided pelvic floor exercise training is superior to oral polyethylene glycol therapy for obstructive defecation.
基金supported by grants from Xinjiang Uyghur Autonomous Region Key Laboratory Open Research Program(No.2018D03002)the National Natural Science Foundation of China(No.81560329)+1 种基金Xinjiang Uyghur Autonomous Region Key Scientific Research Program(No.201430123–2)State Key Laboratory of Pathogenesis,Prevention,Treatment of High Incidence Diseases in Central Asia Fund(No.SKL-HIDCA-2017-Y2)
文摘Background: The University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions are the two most frequently used liver graft preservation fluids. The present study aimed to compare their efficacy in end-stage hepatic alveolar echinococcosis patients who underwent ex-situ liver resection and autotransplantation (ELRA). Methods: A total of 81 patients received ELRA from August 2010 to March 2018. They were allocated into UW ( n = 48) and HTK groups ( n = 33) based on the type of solutions used. Demographic and operational data were retrospectively analyzed. Primary outcomes included 90-day mortality, incidence of early graft loss, primary dysfunction, and postoperative complications. Results: Demographic and operational characteristics were similarly distributed in the two groups. No statistically significant differences were observed with regard to 90-day mortality (12.77% vs. 12.12%) and early graft loss rate (8.51% vs. 9.09%) between the two groups. Patients in the UW and HTK groups showed a primary dysfunction rate of 27.66% and 27.27%, respectively. The UW group exhibited a higher incidence tendency of biliary complications, albeit with no statistical significance. Conclusions: This is the largest cohort study comparing the efficacy of the UW and HTK organ-preserving solutions in end-stage hepatic alveolar echinococcosis patients in ELRA settings. UW and HTK solutions presented similar efficacy and safety. A randomized clinical trial with larger scale is needed for further investigation in future clinical applications.
文摘BACKGROUND The optimal approach for managing hepatic hemangioma is controversial.AIM To evaluate a clinical grading system for management of hepatic hemangioma based on our 17-year of single institution experience.METHODS A clinical grading system was retrospectively applied to 1171 patients with hepatic hemangioma from January 2002 to December 2018.Patients were classified into four groups based on the clinical grading system and treatment:(1)Observation group with score<4(Obs score<4);(2)Surgical group with score<4(Sur score<4);(3)Observation group with score≥4(Obs score≥4);and(4)Surgical group with score≥4(Sur score≥4).The clinico-pathological index and outcomes were evaluated.RESULTS There were significantly fewer symptomatic patients in surgical groups(Sur score≥4 vs Obs score≥4,P<0.001;Sur score<4 vs Obs score<4,χ^(2)=8.60,P=0.004;Sur score≥4 vs Obs score<4,P<0.001).The patients in Sur score≥4 had a lower rate of in need for intervention and total patients with adverse event than in Obs score≥4(P<0.001;P<0.001).Nevertheless,there was no significant difference in need for intervention and total patients with adverse event between the Sur score<4 and Obs score<4(P>0.05;χ^(2)=1.68,P>0.05).CONCLUSION This clinical grading system appeared as a practical tool for hepatic hemangioma.Surgery can be suggested for patients with a score≥4.For those with<4,follow-up should be proposed.
