Systemic sclerosis(SSc)is a multisystem connective-tissue disorder of unknown etiology affecting various internal organs and skin.Esophageal involvement is present in≤70%–90%of the patients and is manifested by seve...Systemic sclerosis(SSc)is a multisystem connective-tissue disorder of unknown etiology affecting various internal organs and skin.Esophageal involvement is present in≤70%–90%of the patients and is manifested by severe gastroesophageal-reflux disease and dysmotility.Although Barrett’s esophagus(BE)has been reported in patients with SSc[1,2],the risk of neoplastic progression has not been reported before in the USA.Therefore,we aimed to study the prevalence of BE in SSc and incidence of neoplastic progression.展开更多
基金supported by NIH grants[U54CA163060,P50CA150964].
文摘Systemic sclerosis(SSc)is a multisystem connective-tissue disorder of unknown etiology affecting various internal organs and skin.Esophageal involvement is present in≤70%–90%of the patients and is manifested by severe gastroesophageal-reflux disease and dysmotility.Although Barrett’s esophagus(BE)has been reported in patients with SSc[1,2],the risk of neoplastic progression has not been reported before in the USA.Therefore,we aimed to study the prevalence of BE in SSc and incidence of neoplastic progression.
