Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis

Objective:To evaluate the antidiabetic activities of ethanolic root extract/fraction of Anthocleista djalonensis(A. djalonensis) in alloxan-induced diabetic rats.Methods: A. djalonensisroot extract/fractions(37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels(BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the treatment.Results:Treatment of alloxan-induced diabetic rats with the extract/fractions caused a significant(P<0.001) reduction in fasting BGLs of the diabetic rats both in acute study and prolonged treatment(2 weeks). The activities of the extract and fractions were more than that of the reference drug, glibenclam ide.Conclusions:These results suggest that the root extract/fractions of A. djalonensispossess antidiabetic effect on alloxan-induced diabetic rats and this justifies its use in ethnomedicine and can be exploited in the management of diabetes.