Supramolecular peptides exhibit obvious similarities with collagen fibers in terms of self-assembly characteristics,nanofibrous structure,and responsiveness to external stimuli.Here,a series of supramolecular peptides...Supramolecular peptides exhibit obvious similarities with collagen fibers in terms of self-assembly characteristics,nanofibrous structure,and responsiveness to external stimuli.Here,a series of supramolecular peptides were developed by altering the amino acid sequence,enabling the self-assembly of three types of 4-biphenylacetic acid(BPAA)-tripeptides into fibrous hydrogel through hydrogen bonding and n-n stacking under the influence of ion induction.Transmission electron and scanning electron microscopies revealed that the diameter of the fiber within nanofibrous hydrogels was~10 and~40 nm,respectively,which was similar with the self-assembled collagen fibers.For this reason,these hydrogels could be considered as a biomimetic extracellular substitute.Meanwhile,the gelation concentration induced by ions was even lower than 0.66 wt%,with an elastic modulus of~0.27 kPa,corresponding to a water content of 99.34 wt%.In addition,the three supramolecular hydrogels were found to be good substrates for L929 cell adhesion and MC-3T3 cell proliferation.The overall results implied that BPAA-based hydrogels have a lucrative application potential as cell carriers.展开更多
Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regu...Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds.展开更多
基金National Nature Science Foundation of China(32071352 and 81860392)Sichuan provincial Key R&D Program of China(2020YFS0462)National Key R&D Project of China(2018YFC1105900).
文摘Supramolecular peptides exhibit obvious similarities with collagen fibers in terms of self-assembly characteristics,nanofibrous structure,and responsiveness to external stimuli.Here,a series of supramolecular peptides were developed by altering the amino acid sequence,enabling the self-assembly of three types of 4-biphenylacetic acid(BPAA)-tripeptides into fibrous hydrogel through hydrogen bonding and n-n stacking under the influence of ion induction.Transmission electron and scanning electron microscopies revealed that the diameter of the fiber within nanofibrous hydrogels was~10 and~40 nm,respectively,which was similar with the self-assembled collagen fibers.For this reason,these hydrogels could be considered as a biomimetic extracellular substitute.Meanwhile,the gelation concentration induced by ions was even lower than 0.66 wt%,with an elastic modulus of~0.27 kPa,corresponding to a water content of 99.34 wt%.In addition,the three supramolecular hydrogels were found to be good substrates for L929 cell adhesion and MC-3T3 cell proliferation.The overall results implied that BPAA-based hydrogels have a lucrative application potential as cell carriers.
文摘Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds.
