Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty-two children (4-10 y) with acute respir...Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty-two children (4-10 y) with acute respiratory symp-toms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double-blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125-mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications. Results: A total of 72 children (88% ) completed follow-up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90% ). The proportion of children completely cured by day 14 was similar in both groups (difference 6% , 95% confidence interval -16% to 29% ). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7% , -9% to 24% ). Conclusion: A 10-d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.展开更多
文摘Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty-two children (4-10 y) with acute respiratory symp-toms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double-blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125-mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications. Results: A total of 72 children (88% ) completed follow-up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90% ). The proportion of children completely cured by day 14 was similar in both groups (difference 6% , 95% confidence interval -16% to 29% ). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7% , -9% to 24% ). Conclusion: A 10-d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.
