Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling o...Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.展开更多
基金supported by the Bayerische Forschungsstiftung to B.K.the Deutsche Forschungsgemeinschaft (CRC1181 to G.K.and G.S.+3 种基金SCHE 2062/1-1 to C.S.)funded by the Wellcome Trust Investigator Award (107964/Z/15/Z)the UK Dementia Research Institutefunded by BBSRC Discovery Fellowship (BB/T009543/1)。
文摘Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.
