To evaluate the rate of chromosomal abnormalities in babies conceived by intra cytoplasmic sperm injection (ICSI). Retrospective case-control analysis. Privat e IVF center. One thousand one hundred thirty-six karyotyp...To evaluate the rate of chromosomal abnormalities in babies conceived by intra cytoplasmic sperm injection (ICSI). Retrospective case-control analysis. Privat e IVF center. One thousand one hundred thirty-six karyotype results obtained fr om fetuses conceived by ICSI. Amniocentesis and prenatal karyotyping. Presence o f normal and abnormal chromosomal configurations. Abnormal karyotypes were detec ted in 17 (1.5%) of 1,136 fetuses. Eight (0.7%) of these were from singleton a nd nine (0.8%) from twin pregnancies. There was no difference in the autosomal chromosome structure or the number or structure of sex chromosomes in karyotyped fetuses of singleton and twin pregnancies. However, abnormal numbers of autosom al chromosomes were more frequent in singletons (2.3%) than in twins (1.1%). T here was also no difference in the frequency of chromosomal aberrations between ICSI groups in which ejaculated s permatozoa (1.9%) and testicular spermatozoa (1.5%) were used. There was no di fference in the frequency of chromosomal aberrations between fetuses for whom IC SI was used because of male factors (1.8%) compared with babies for whom ICSI w as also the choice of assisted fertilization method for other types of infertili ty factors (0.9%). Sperm source does not influence the karyotype of babies conc eived by ICSI. By comparing our results with previously reported data from natur al pregnancies, we show that ICSI babies carry a significantly increased risk of an abnormal karyotype. However, the increased risk is similar among the differe nt infertility groups.展开更多
文摘To evaluate the rate of chromosomal abnormalities in babies conceived by intra cytoplasmic sperm injection (ICSI). Retrospective case-control analysis. Privat e IVF center. One thousand one hundred thirty-six karyotype results obtained fr om fetuses conceived by ICSI. Amniocentesis and prenatal karyotyping. Presence o f normal and abnormal chromosomal configurations. Abnormal karyotypes were detec ted in 17 (1.5%) of 1,136 fetuses. Eight (0.7%) of these were from singleton a nd nine (0.8%) from twin pregnancies. There was no difference in the autosomal chromosome structure or the number or structure of sex chromosomes in karyotyped fetuses of singleton and twin pregnancies. However, abnormal numbers of autosom al chromosomes were more frequent in singletons (2.3%) than in twins (1.1%). T here was also no difference in the frequency of chromosomal aberrations between ICSI groups in which ejaculated s permatozoa (1.9%) and testicular spermatozoa (1.5%) were used. There was no di fference in the frequency of chromosomal aberrations between fetuses for whom IC SI was used because of male factors (1.8%) compared with babies for whom ICSI w as also the choice of assisted fertilization method for other types of infertili ty factors (0.9%). Sperm source does not influence the karyotype of babies conc eived by ICSI. By comparing our results with previously reported data from natur al pregnancies, we show that ICSI babies carry a significantly increased risk of an abnormal karyotype. However, the increased risk is similar among the differe nt infertility groups.
