Latency is the pivotal factor that governs the long-term pathogenecity and persistence of HIV-1 infection.It is also the primary impediment to cure and successful treatment,resulting in patient death.Latency of HIV-1 ...Latency is the pivotal factor that governs the long-term pathogenecity and persistence of HIV-1 infection.It is also the primary impediment to cure and successful treatment,resulting in patient death.Latency of HIV-1 infection promotes failure of the conventional antiretroviral therapy(ART).Cessation of ART immediately leads to viral reactivation and attainment of viral load in peripheral circulation.ART comes with severe side effects and is ineffective at treating latent infection.To eliminate latent infection,alternate therapeutic strategies such as Shock and Kill,Block and Lock,gene editing and vaccination have been proposed.Although these strategies have experimentally been proven successful,they possess major limitations.Hence,in this hypothesis,an alternate therapeutic strategy has been proposed to solve the threat of HIV-latency.The proposed model encompasses the generation and administration of recombinant HIV-1 particles whose genomes having pro-apoptotic gene,tBid,will activate apoptotic cell death pathways after infecting only the latent cells,thereby removing latent HIV host cells from patients’bodies.展开更多
文摘Latency is the pivotal factor that governs the long-term pathogenecity and persistence of HIV-1 infection.It is also the primary impediment to cure and successful treatment,resulting in patient death.Latency of HIV-1 infection promotes failure of the conventional antiretroviral therapy(ART).Cessation of ART immediately leads to viral reactivation and attainment of viral load in peripheral circulation.ART comes with severe side effects and is ineffective at treating latent infection.To eliminate latent infection,alternate therapeutic strategies such as Shock and Kill,Block and Lock,gene editing and vaccination have been proposed.Although these strategies have experimentally been proven successful,they possess major limitations.Hence,in this hypothesis,an alternate therapeutic strategy has been proposed to solve the threat of HIV-latency.The proposed model encompasses the generation and administration of recombinant HIV-1 particles whose genomes having pro-apoptotic gene,tBid,will activate apoptotic cell death pathways after infecting only the latent cells,thereby removing latent HIV host cells from patients’bodies.
