We present a rare case of a 50-year old lady who presented with pain abdomen and bleeding per vaginum of 3 months duration. Per vaginal examination revealed an exophytic growth arising from vault. Histopathological ex...We present a rare case of a 50-year old lady who presented with pain abdomen and bleeding per vaginum of 3 months duration. Per vaginal examination revealed an exophytic growth arising from vault. Histopathological examination of the vault biopsy showed malignant neoplasm with features suggestive of carcinosarcoma of vault with immunohistochemistry showing stromal cells positive for CD10 and negative for SMA. Ki67 index was 40%-50%. She received external beam radiotherapy to pelvis 50.4 Gy/25 fractions but did not respond to the same. The lesion was not surgically resectable and hence referred to the division of medical oncology for chemotherapy. She was started on ifosphamide with cisplatin with growth factor support. It was planned to do a reassessment after 3 cycles of chemotherapy, but patient succumbed to the illness.展开更多
Diagnosis of leukemia during pregnancy is a dramatic event that poses challenges to the pregnant woman,the family,and physicians.Chronic myeloid leukemia(CML)comprises up to 10%of pregnancy-associated leukemia.There i...Diagnosis of leukemia during pregnancy is a dramatic event that poses challenges to the pregnant woman,the family,and physicians.Chronic myeloid leukemia(CML)comprises up to 10%of pregnancy-associated leukemia.There is no specifi c guideline for CML management in pregnant women.This study reported a case of successful pregnancy after 12 years of chemotherapy including tyrosine kinase inhibitor for CML.Pregnancy after 12 years of continuous chemotherapy is rare,which also led a challenge for medical oncologists and patient as well.This study described the assessment of the risk balance and benefi t and management of such a patient.展开更多
文摘We present a rare case of a 50-year old lady who presented with pain abdomen and bleeding per vaginum of 3 months duration. Per vaginal examination revealed an exophytic growth arising from vault. Histopathological examination of the vault biopsy showed malignant neoplasm with features suggestive of carcinosarcoma of vault with immunohistochemistry showing stromal cells positive for CD10 and negative for SMA. Ki67 index was 40%-50%. She received external beam radiotherapy to pelvis 50.4 Gy/25 fractions but did not respond to the same. The lesion was not surgically resectable and hence referred to the division of medical oncology for chemotherapy. She was started on ifosphamide with cisplatin with growth factor support. It was planned to do a reassessment after 3 cycles of chemotherapy, but patient succumbed to the illness.
文摘Diagnosis of leukemia during pregnancy is a dramatic event that poses challenges to the pregnant woman,the family,and physicians.Chronic myeloid leukemia(CML)comprises up to 10%of pregnancy-associated leukemia.There is no specifi c guideline for CML management in pregnant women.This study reported a case of successful pregnancy after 12 years of chemotherapy including tyrosine kinase inhibitor for CML.Pregnancy after 12 years of continuous chemotherapy is rare,which also led a challenge for medical oncologists and patient as well.This study described the assessment of the risk balance and benefi t and management of such a patient.
