The role of contact allergy in rosacea has rarely been investigated. In this retrospective study, 361 out of 76 697 patients tested and documented by the Information Network of Departments of Dermatology between 1995 ...The role of contact allergy in rosacea has rarely been investigated. In this retrospective study, 361 out of 76 697 patients tested and documented by the Information Network of Departments of Dermatology between 1995 and 2002 had rosacea. Patch tests included standard series and constituents of cosmetics and topical medicaments. 118/361 had additionally been patch tested with their own cosmetics/medicaments. Positive reactions occurred to nickel (II) sulfate in 9.3% , fragrance mix in 8.8% , thimerosal in 6.9% , Myroxylon pereirae resin in 5.9% , potassium dichromate in 4.6% and propolis in 2.8% . Whereas rosacea patients had a significantly high er risk of contactallergy to propolis compared to the remaining patients, in an age- and sex- adjustedanalysis,contactallergy to nickel was significantly less frequent in this group. For Lyral., the risk was elevated, albeit not significantly. Only 2/329 patients were positive to neomycin sulfate and 1/100 to gentamicin sulfate, among the panel of (topical) antibiotics tested. Among 118 patients tested with their own products, 3 were tested to metronidazole, 1 reacting positively. Irritant or doubtful patch test reactions were provoked by various substances (vehicles, oxidants and preservatives of various creams), which might also be clinically important, considering the heightened sensitivity of rosaceous skin.展开更多
In view of the wide variety of components currently used in metalworking fluids (MWF), relevant contact sensitizations may be overlooked, because commercially available MWF test series cannot cover the full spectrum. ...In view of the wide variety of components currently used in metalworking fluids (MWF), relevant contact sensitizations may be overlooked, because commercially available MWF test series cannot cover the full spectrum. Hence, patch testing with MWF from the patient’s workplace is an important additional diagnostic tool. However, recommendations on how to perform such patch tests vary. We retrospectively analyzed patch test data of the Department of Dermatology in Dortmund, 1992-2003. In 141 metalworkers tested because of suspected occupational contact dermatitis due to MWF, 829 patch tests with 306 samples of MWF were performed. Water-based MWF (wb MWF) were mainly tested in 2 dilution series, i.e. pure (workplace concentration), 10%aq. and 1%aq., and pure, 50%aq. and 10%aq. Positive reactions to wb MWF occurred in 27 patients. Patch testing with wb MWF at workplace concentration resulted in 16.1 %(39/242) positive reactions, with a positivity ratio of 69%and a reaction index of 0. From the analysis of reaction patterns and concomitant reactions,we conclude that most of these positive reactions indicated true contact allergy. With lower concentrations, relevant allergic reactions may be missed. Neat oils were tested as is or diluted from 1 to 50%in olive oil, but no reactions at all were observed. For optimum benefit of patch testing with MWF from the patient’s workplace, breakdown testing is recommended. To overcome the time-consuming difficulties associated with this procedure, we propose a centre for information and documentation of contact allergies due to occupational exposure. Furthermore, full declaration of MWF ingredients is desirable.展开更多
Allergic contact dermatitis (ACD) affects approximately 7%of the general population. To evaluate the frequency of ACD in children,we analysed patch test results collected by the Information Network of Departments of D...Allergic contact dermatitis (ACD) affects approximately 7%of the general population. To evaluate the frequency of ACD in children,we analysed patch test results collected by the Information Network of Departments of Dermatology between 1995 and 2002. Data of 285 children (6-12 year) and 2175 adolescent patients (13-18 year) were analysed to determine the frequency of sensitization to the 30 most common contact allergens,adjusting for age and sex. As control group,we defined adult patients (60-66 year,n=7904). The top allergens in children were thimerosal,gentamicin sulphate,nickel-II-sulphate,ammoniated mercury,cobalt-II-chloride,fragrance mix,bufexamac,Compositae mix,propylene glycol and turpentine. The overall proportion of sensitized patients according to the patch test results was 52.6%in the children group compared to 49.7%in the adolescent group. These findings were similar in the adult group at 52.2%. The detailed analysis regarding sex,occupation,atopy,site of eczema and age showed distinct patterns in each group indicating age-specific exposures. Atopy-related diseases were more common in children compared to adults. On the basis of the data of this study,the relationship between atopy and the risk of development of ACD,at least in children,needs further investigation.展开更多
The purpose of the study was to evaluate the incidence of hand dermatitis, the impact of potential risk factors and the efficacy of skin bioengineering in a prospectively followed cohort of apprentice nurses. 104 part...The purpose of the study was to evaluate the incidence of hand dermatitis, the impact of potential risk factors and the efficacy of skin bioengineering in a prospectively followed cohort of apprentice nurses. 104 participants were prospectively followed for 3 years. Before the start of training, after about 1 year and in the third year of occupational exposure, a standardized questionnaire was distributed, and a clinical examination with skin bioengineering of the dorsum of hand and forearm was performed. The 12-month period prevalence of self-reported symptoms of hand dermatitis was 36.5% 95%-confidence interval (CI) 27.3-46.6 at intermediate follow-up and 43.3%(95%-CI 33.6-53.3) at the final examination. Apprentices with self-reported symptoms at the final examination showed a significant increase of transepidermal water loss (TEWL) at the dorsal hand from 10.15 g/ m2h to 13.55 g/m2h. TEWL at this site did, at the initial examination, not differ significantly be-tween persons who later reported symptoms of hand dermatitis at the final examination and those who did not (10.50 g/m 2h versus 10.15 g/m2h, respectively). Our results do not support the notion that an increased basal TEWL is a good indicator for hand dermatitis risk.展开更多
In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25%and 0.5%aq. has been added to routine allergen patc h tests to assess its properties as a convenient diagnostic ...In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25%and 0.5%aq. has been added to routine allergen patc h tests to assess its properties as a convenient diagnostic indicator of individ ual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors o f contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, t he impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. A s a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5%SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an e ven weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almos t halved the odds of an irritant SLS reaction. In conclusion, this type of SLS p atch test can be regarded as robust, indicating individual irritability relative ly independent from the individual factors analysed here.展开更多
文摘The role of contact allergy in rosacea has rarely been investigated. In this retrospective study, 361 out of 76 697 patients tested and documented by the Information Network of Departments of Dermatology between 1995 and 2002 had rosacea. Patch tests included standard series and constituents of cosmetics and topical medicaments. 118/361 had additionally been patch tested with their own cosmetics/medicaments. Positive reactions occurred to nickel (II) sulfate in 9.3% , fragrance mix in 8.8% , thimerosal in 6.9% , Myroxylon pereirae resin in 5.9% , potassium dichromate in 4.6% and propolis in 2.8% . Whereas rosacea patients had a significantly high er risk of contactallergy to propolis compared to the remaining patients, in an age- and sex- adjustedanalysis,contactallergy to nickel was significantly less frequent in this group. For Lyral., the risk was elevated, albeit not significantly. Only 2/329 patients were positive to neomycin sulfate and 1/100 to gentamicin sulfate, among the panel of (topical) antibiotics tested. Among 118 patients tested with their own products, 3 were tested to metronidazole, 1 reacting positively. Irritant or doubtful patch test reactions were provoked by various substances (vehicles, oxidants and preservatives of various creams), which might also be clinically important, considering the heightened sensitivity of rosaceous skin.
文摘In view of the wide variety of components currently used in metalworking fluids (MWF), relevant contact sensitizations may be overlooked, because commercially available MWF test series cannot cover the full spectrum. Hence, patch testing with MWF from the patient’s workplace is an important additional diagnostic tool. However, recommendations on how to perform such patch tests vary. We retrospectively analyzed patch test data of the Department of Dermatology in Dortmund, 1992-2003. In 141 metalworkers tested because of suspected occupational contact dermatitis due to MWF, 829 patch tests with 306 samples of MWF were performed. Water-based MWF (wb MWF) were mainly tested in 2 dilution series, i.e. pure (workplace concentration), 10%aq. and 1%aq., and pure, 50%aq. and 10%aq. Positive reactions to wb MWF occurred in 27 patients. Patch testing with wb MWF at workplace concentration resulted in 16.1 %(39/242) positive reactions, with a positivity ratio of 69%and a reaction index of 0. From the analysis of reaction patterns and concomitant reactions,we conclude that most of these positive reactions indicated true contact allergy. With lower concentrations, relevant allergic reactions may be missed. Neat oils were tested as is or diluted from 1 to 50%in olive oil, but no reactions at all were observed. For optimum benefit of patch testing with MWF from the patient’s workplace, breakdown testing is recommended. To overcome the time-consuming difficulties associated with this procedure, we propose a centre for information and documentation of contact allergies due to occupational exposure. Furthermore, full declaration of MWF ingredients is desirable.
文摘Allergic contact dermatitis (ACD) affects approximately 7%of the general population. To evaluate the frequency of ACD in children,we analysed patch test results collected by the Information Network of Departments of Dermatology between 1995 and 2002. Data of 285 children (6-12 year) and 2175 adolescent patients (13-18 year) were analysed to determine the frequency of sensitization to the 30 most common contact allergens,adjusting for age and sex. As control group,we defined adult patients (60-66 year,n=7904). The top allergens in children were thimerosal,gentamicin sulphate,nickel-II-sulphate,ammoniated mercury,cobalt-II-chloride,fragrance mix,bufexamac,Compositae mix,propylene glycol and turpentine. The overall proportion of sensitized patients according to the patch test results was 52.6%in the children group compared to 49.7%in the adolescent group. These findings were similar in the adult group at 52.2%. The detailed analysis regarding sex,occupation,atopy,site of eczema and age showed distinct patterns in each group indicating age-specific exposures. Atopy-related diseases were more common in children compared to adults. On the basis of the data of this study,the relationship between atopy and the risk of development of ACD,at least in children,needs further investigation.
文摘The purpose of the study was to evaluate the incidence of hand dermatitis, the impact of potential risk factors and the efficacy of skin bioengineering in a prospectively followed cohort of apprentice nurses. 104 participants were prospectively followed for 3 years. Before the start of training, after about 1 year and in the third year of occupational exposure, a standardized questionnaire was distributed, and a clinical examination with skin bioengineering of the dorsum of hand and forearm was performed. The 12-month period prevalence of self-reported symptoms of hand dermatitis was 36.5% 95%-confidence interval (CI) 27.3-46.6 at intermediate follow-up and 43.3%(95%-CI 33.6-53.3) at the final examination. Apprentices with self-reported symptoms at the final examination showed a significant increase of transepidermal water loss (TEWL) at the dorsal hand from 10.15 g/ m2h to 13.55 g/m2h. TEWL at this site did, at the initial examination, not differ significantly be-tween persons who later reported symptoms of hand dermatitis at the final examination and those who did not (10.50 g/m 2h versus 10.15 g/m2h, respectively). Our results do not support the notion that an increased basal TEWL is a good indicator for hand dermatitis risk.
文摘In a multicentre study of the German Contact Dermatitis Research Group, sodium lauryl sulfate (SLS) 0.25%and 0.5%aq. has been added to routine allergen patc h tests to assess its properties as a convenient diagnostic indicator of individ ual susceptibility to irritation at the time of patch testing. Previous studies indicated that irritant SLS reactivity may be related to individual factors such as age and sex. As these factors are, in turn, among the important predictors o f contact allergy to many allergens, e.g. summarized in the ‘MOAHLFA index’, t he impact of the MOAHLFA factors on irritant SLS patch test reactivity, and thus a potential for confounding, was assessed in the 5971 participating patients. A s a result of 2 logistic regression analyses with an irritant reaction to 0.25% and 0.5%SLS, respectively, as outcome, male sex was identified as a relatively weak but significant risk factor (OR 1.38), while age 40 years or older was an e ven weaker risk factor (OR 1.22 and 1.15, respectively). Upon detailed analysis, no clear age gradient could, however, be identified. 1-day exposure time almos t halved the odds of an irritant SLS reaction. In conclusion, this type of SLS p atch test can be regarded as robust, indicating individual irritability relative ly independent from the individual factors analysed here.
