Model for Endstage Liver Disease(MELD) score has been used to allocate organs since February 2002.This policy allocates organs to candidates with regard to severity of their underlying liver disease except in the case...Model for Endstage Liver Disease(MELD) score has been used to allocate organs since February 2002.This policy allocates organs to candidates with regard to severity of their underlying liver disease except in the case of hepatocellular carcinoma(HCC) patients.The purpose of this study was to determine the impact of MELD on waiting times,dropout rates,and transplantation rates in all patients awaiting liver transplantation at our center.The records of all patients listed for liver transplantation between May 28,1999,and February 27,2004,at the Mayo Clinic,Scottsdale,Arizona,were reviewed.Candidates were grouped by two time periods as pre-MELD or post-MELD based on date of MELD implementation(February 27,2002) .The incidence of deceased donor liver transplantation(DDLT) ,waiting time to DDLT,dropout rate from the waiting list because of clinical deterioration or death,and survival while waiting for or after DDLT were determined for each group.Three hundred fifty-one patients were listed for liver transplantation(195 pre-MELD,156 post-MELD) during the study period.HCC patients had an improved rate of transplantation after MELD(pre-MELD,1.39 persons per year;post-MELD,3.48 persons per year) .In all groups,with the exception of hepatitis C virus,the transplantation rates were the same for both categories.The hepatitis C virus group also had improved transplantation rates in the post-MELD period.HCC candidates under the new allocation policy have an increased incidence of DDLT in our institution.However,this has not disadvantaged patients with non-HCC diagnoses.Thus,the new MELD-based allocation policy has benefited all candidates by allowing more timely transplants.展开更多
Along with the construction of non-Lorentz-invariant effective field theories, recent studies which are based on geometric models of Finsler space-time become more and more popular. In this respect, the Finslerian app...Along with the construction of non-Lorentz-invariant effective field theories, recent studies which are based on geometric models of Finsler space-time become more and more popular. In this respect, the Finslerian approach to the problem of Lorentz symmetry violation is characterized by the fact that the violation of Lorentz symmetry is not accompanied by a violation of relativistic symmetry. That means, in particular, that preservation of relativistic symmetry can be considered as a rigorous criterion of the viability for any non-Lorentz-invariant effective field theory. Although this paper has a review character, it contains (with few exceptions) only those results on Finsler extensions of relativity theory, that were obtained by the authors.展开更多
文摘Model for Endstage Liver Disease(MELD) score has been used to allocate organs since February 2002.This policy allocates organs to candidates with regard to severity of their underlying liver disease except in the case of hepatocellular carcinoma(HCC) patients.The purpose of this study was to determine the impact of MELD on waiting times,dropout rates,and transplantation rates in all patients awaiting liver transplantation at our center.The records of all patients listed for liver transplantation between May 28,1999,and February 27,2004,at the Mayo Clinic,Scottsdale,Arizona,were reviewed.Candidates were grouped by two time periods as pre-MELD or post-MELD based on date of MELD implementation(February 27,2002) .The incidence of deceased donor liver transplantation(DDLT) ,waiting time to DDLT,dropout rate from the waiting list because of clinical deterioration or death,and survival while waiting for or after DDLT were determined for each group.Three hundred fifty-one patients were listed for liver transplantation(195 pre-MELD,156 post-MELD) during the study period.HCC patients had an improved rate of transplantation after MELD(pre-MELD,1.39 persons per year;post-MELD,3.48 persons per year) .In all groups,with the exception of hepatitis C virus,the transplantation rates were the same for both categories.The hepatitis C virus group also had improved transplantation rates in the post-MELD period.HCC candidates under the new allocation policy have an increased incidence of DDLT in our institution.However,this has not disadvantaged patients with non-HCC diagnoses.Thus,the new MELD-based allocation policy has benefited all candidates by allowing more timely transplants.
基金partially supported by the Sectorial Operational Program Human Resources Development(SOP HRD)financed from the European Social Fund and by the Romanian Government under the Project number POSDRU/89/1.5/S/59323.
文摘Along with the construction of non-Lorentz-invariant effective field theories, recent studies which are based on geometric models of Finsler space-time become more and more popular. In this respect, the Finslerian approach to the problem of Lorentz symmetry violation is characterized by the fact that the violation of Lorentz symmetry is not accompanied by a violation of relativistic symmetry. That means, in particular, that preservation of relativistic symmetry can be considered as a rigorous criterion of the viability for any non-Lorentz-invariant effective field theory. Although this paper has a review character, it contains (with few exceptions) only those results on Finsler extensions of relativity theory, that were obtained by the authors.
