The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, bu...The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, but little has been reported on their metabolism and pharmacology, except that they do not appear to activate prostanoid or cannabinoid receptors. These studies were performed to determine if prostamides exhibit simi-展开更多
文摘The prostamides (prostaglandin-ethanolamides) are produced from the action of cyclooxygenase-2 (COX-2) on anandamide. So far prostamide E2, D2 and F2alpha and their synthetic analog Bimatoprost have been described, but little has been reported on their metabolism and pharmacology, except that they do not appear to activate prostanoid or cannabinoid receptors. These studies were performed to determine if prostamides exhibit simi-
