Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded.Nevertheless,they have a number of drawbacks including the insufficient level of mechanical propertie...Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded.Nevertheless,they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate.Struvite(MgNH4PO4)-based cements,which grew in popularity in recent years,despite their neutral pH and acceptable mechanical performance,release undesirable NH4+ions during their resorption.This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium,however,such cements have a pH values of 9–10,leading to cytotoxicity.Thus,the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties:neutral pH,sufficient mechanical properties,and the absence of cytotoxicity,applying Na2HPO4-based cement liquid.For this purpose,cement powders precursors in the CaO-MgO-P2O5 system were synthesized by one-pot process in a wide composition range,and their properties were investigated.The optimal performance was observed for the cements with(Ca+Mg)/P ratio of 1.67,which are characterized by newberyite phase formation during setting reaction,pH values close to 7,sufficient compressive strength up to 22±3 MPa(for 20 mol.%of Mg),dense microstructure and adequate matrix properties of the surface.This set of features make those materials promising candidates for medical applications.展开更多
In the present study, the Pulsed Laser Deposition (PLD) technique was applied to coat titanium for orthopaedicand dental implant applications. Calcium carbonate (CC) was used as starting coating material.The deposited...In the present study, the Pulsed Laser Deposition (PLD) technique was applied to coat titanium for orthopaedicand dental implant applications. Calcium carbonate (CC) was used as starting coating material.The deposited CC films were transformed into octacalcium phosphate (OCP) by chemical treatments. Theresults of X-ray diffraction (XRD), Raman, Fourier Transform Infrared Spectroscopy (FTIR) and scanningelectron microscopy (SEM) studies revealed that the final OCP thin films are formed on the titaniumsurface. Human myofibroblasts from peripheral vessels and the primary bone marrow mesenchymalstromal cells (BMMSs) were cultured on the investigated materials. It was shown that all the investigatedsamples had no short-term toxic effects on cells. The rate of division of myofibroblast cells growing onthe surface and saturated BMMSs concentration for the OCP coating were about two times faster than ofcells growing on the CC films.展开更多
基金financially support by Russian Foundation for Basic Research(Grant No.18-33-20170).
文摘Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded.Nevertheless,they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate.Struvite(MgNH4PO4)-based cements,which grew in popularity in recent years,despite their neutral pH and acceptable mechanical performance,release undesirable NH4+ions during their resorption.This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium,however,such cements have a pH values of 9–10,leading to cytotoxicity.Thus,the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties:neutral pH,sufficient mechanical properties,and the absence of cytotoxicity,applying Na2HPO4-based cement liquid.For this purpose,cement powders precursors in the CaO-MgO-P2O5 system were synthesized by one-pot process in a wide composition range,and their properties were investigated.The optimal performance was observed for the cements with(Ca+Mg)/P ratio of 1.67,which are characterized by newberyite phase formation during setting reaction,pH values close to 7,sufficient compressive strength up to 22±3 MPa(for 20 mol.%of Mg),dense microstructure and adequate matrix properties of the surface.This set of features make those materials promising candidates for medical applications.
基金This work was supported by the Russian Science Foundation(project N15-19-00078)Authors are grateful to Mr.M.Ortenzi,G.De Santis and G.Emma for technical support and assistance.
文摘In the present study, the Pulsed Laser Deposition (PLD) technique was applied to coat titanium for orthopaedicand dental implant applications. Calcium carbonate (CC) was used as starting coating material.The deposited CC films were transformed into octacalcium phosphate (OCP) by chemical treatments. Theresults of X-ray diffraction (XRD), Raman, Fourier Transform Infrared Spectroscopy (FTIR) and scanningelectron microscopy (SEM) studies revealed that the final OCP thin films are formed on the titaniumsurface. Human myofibroblasts from peripheral vessels and the primary bone marrow mesenchymalstromal cells (BMMSs) were cultured on the investigated materials. It was shown that all the investigatedsamples had no short-term toxic effects on cells. The rate of division of myofibroblast cells growing onthe surface and saturated BMMSs concentration for the OCP coating were about two times faster than ofcells growing on the CC films.
