The SARS-CoV-2 outbreaks highlighted the need for effective,reliable,fast,easy-to-do and cheap diagnostics procedures.We pragmatically experienced that an early positive-case detection,inevitably coupled with a mass v...The SARS-CoV-2 outbreaks highlighted the need for effective,reliable,fast,easy-to-do and cheap diagnostics procedures.We pragmatically experienced that an early positive-case detection,inevitably coupled with a mass vaccination campaign,is a milestone to control the COVID-19 pandemic.Gold nanoparticles(AuNPs)can indeed play a crucial role in this context,as their physicochemical,optics and electronics properties are being extensively used in photothermal therapy(PTT),radiation therapy(RT),drug delivery and diagnostic.AuNPs can be synthesized by several approaches to obtain different sizes and shapes that can be easily functionalized with many kinds of molecules such as antibodies,proteins,probes,and lipids.In addition,AuNPs showed high biocompatibility making them useful tool in medicine field.We thus reviewed here the most relevant evidence on AuNPs as effective way to detect the presence of SARS-CoV-2 antigens.We trust future diagnostic efforts must take this‘old-fashioned’nanotechnology tool into consideration for the development and commercialization of reliable and feasible detection kits.展开更多
基金V.D.M.kindly acknowledges Programma Operativo Nazionale(PON)Ricerca e Innovazione 2014-20202014-azione IV.6“Contratti su tematiche green”-DM 1062/2021 for sponsoring her salary and work.L.R.kindly acknowledges the ERC-2019-StG(Grant No.850936)and Fondazione Cariplo(Grant No.2019-4278)for supporting his research activities.
文摘The SARS-CoV-2 outbreaks highlighted the need for effective,reliable,fast,easy-to-do and cheap diagnostics procedures.We pragmatically experienced that an early positive-case detection,inevitably coupled with a mass vaccination campaign,is a milestone to control the COVID-19 pandemic.Gold nanoparticles(AuNPs)can indeed play a crucial role in this context,as their physicochemical,optics and electronics properties are being extensively used in photothermal therapy(PTT),radiation therapy(RT),drug delivery and diagnostic.AuNPs can be synthesized by several approaches to obtain different sizes and shapes that can be easily functionalized with many kinds of molecules such as antibodies,proteins,probes,and lipids.In addition,AuNPs showed high biocompatibility making them useful tool in medicine field.We thus reviewed here the most relevant evidence on AuNPs as effective way to detect the presence of SARS-CoV-2 antigens.We trust future diagnostic efforts must take this‘old-fashioned’nanotechnology tool into consideration for the development and commercialization of reliable and feasible detection kits.
