Six new oligomeric neolignans including two trimeric neolignans(1 and 2)and four dimeric neolignans(3–6)were isolated from the leaves of Magnolia officinalis var.biloba.Their structures were determined based on HR-ES...Six new oligomeric neolignans including two trimeric neolignans(1 and 2)and four dimeric neolignans(3–6)were isolated from the leaves of Magnolia officinalis var.biloba.Their structures were determined based on HR-ESIMS and NMR data,as well as electronic circular dichroism(ECD)calculations.Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety,which is an unprecedented type of linkage between monomers.All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells.Compounds 1 and 3 showed significantly inhibitory activities with IC50 values of 6.04 and 3.26μmol·L^(−1),respectively.展开更多
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)the Drug Innovation Major Project(No.2018ZX09711-001-007)the 111 Project from Ministry of Education of China,and the State Administration of Foreign Export Affairs of China(No.B18056).
文摘Six new oligomeric neolignans including two trimeric neolignans(1 and 2)and four dimeric neolignans(3–6)were isolated from the leaves of Magnolia officinalis var.biloba.Their structures were determined based on HR-ESIMS and NMR data,as well as electronic circular dichroism(ECD)calculations.Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety,which is an unprecedented type of linkage between monomers.All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells.Compounds 1 and 3 showed significantly inhibitory activities with IC50 values of 6.04 and 3.26μmol·L^(−1),respectively.
