Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of patients.Worldwide,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing ...Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of patients.Worldwide,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing a 7%increase per year since 1991.1 Improved transplant strategies and therapeutic efficacy have made HSCT a curative option for various indications,mostly comprising malignant blood cell pathologies but also including solid tumors or benign conditions.2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation(TBI).2 These treatments usually lead to permanent infertility.3 In men,the consequences include the impairment and reduction of Sertoli and Leydig cells,leading to the suppression of the spermatogonia pool and increased release of gonadotrophin.3 Although sperm banking can mitigate the risk of infertility.展开更多
文摘Dear Editor,Allogeneic or autologous hematopoietic stem cell transplantation(HSCT)concerns an increasing number of patients.Worldwide,89070 allogeneic and autologous HSCT procedures were reported in 2016,representing a 7%increase per year since 1991.1 Improved transplant strategies and therapeutic efficacy have made HSCT a curative option for various indications,mostly comprising malignant blood cell pathologies but also including solid tumors or benign conditions.2 The conditioning regimen for transplantation often includes alkylating agents and/or total body irradiation(TBI).2 These treatments usually lead to permanent infertility.3 In men,the consequences include the impairment and reduction of Sertoli and Leydig cells,leading to the suppression of the spermatogonia pool and increased release of gonadotrophin.3 Although sperm banking can mitigate the risk of infertility.
